Comparing Self-Reported Sugar Intake With the Sucrose and Fructose Biomarker From Overnight Urine Samples in Relation to Cardiometabolic Risk Factors
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Comparing Self-Reported Sugar Intake With the Sucrose and Fructose Biomarker From Overnight Urine Samples in Relation to Cardiometabolic Risk Factors. / Ramne, Stina; Gray, Nicola; Hellstrand, Sophie; Brunkwall, Louise; Enhörning, Sofia; Nilsson, Peter M.; Engström, Gunnar; Orho-Melander, Marju; Ericson, Ulrika; Kuhnle, Gunter G.C.; Sonestedt, Emily.
In: Frontiers in Nutrition, Vol. 7, 62, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparing Self-Reported Sugar Intake With the Sucrose and Fructose Biomarker From Overnight Urine Samples in Relation to Cardiometabolic Risk Factors
AU - Ramne, Stina
AU - Gray, Nicola
AU - Hellstrand, Sophie
AU - Brunkwall, Louise
AU - Enhörning, Sofia
AU - Nilsson, Peter M.
AU - Engström, Gunnar
AU - Orho-Melander, Marju
AU - Ericson, Ulrika
AU - Kuhnle, Gunter G.C.
AU - Sonestedt, Emily
N1 - Funding Information: We thank all the participants and research staff in the Malm? Offspring Study. Funding. This study was funded by the Swedish Research Council (2016-01501); the Heart and Lung Foundation (2016-0267); and the Albert P?hlsson Foundation. The MOS was supported by grants from the Swedish Research Council (521-2013-2756, 2013-210, 2014-366, 2018-02784); the Heart and Lung Foundation (2015-0427, 2013-0598, 2017-0523); the Region Sk?ne, Sk?ne University Hospital; the European Research Council (ERC-CoG-2014-649021); the EFSD Lilly Award 2014 (2015-338); the Swedish Diabetes Foundation (DIA 2018-358); and the Novo Nordisk Foundation (NNF17OC0027348, NNF18OC0034386). We also acknowledge the support provided by the Swedish Foundation for Strategic Research (IRC15-0067). Funding Information: This study was funded by the Swedish Research Council (2016-01501); the Heart and Lung Foundation (2016-0267); and the Albert Påhlsson Foundation. The MOS was supported by grants from the Swedish Research Council (521-2013-2756, 2013-210, 2014-366, 2018-02784); the Heart and Lung Foundation (2015-0427, 2013-0598, 2017-0523); the Region Skåne, Skåne University Hospital; the European Research Council (ERC-CoG-2014-649021); the EFSD Lilly Award 2014 (2015-338); the Swedish Diabetes Foundation (DIA 2018-358); and the Novo Nordisk Foundation (NNF17OC0027348, NNF18OC0034386). We also acknowledge the support provided by the Swedish Foundation for Strategic Research (IRC15-0067). Publisher Copyright: © Copyright © 2020 Ramne, Gray, Hellstrand, Brunkwall, Enhörning, Nilsson, Engström, Orho-Melander, Ericson, Kuhnle and Sonestedt.
PY - 2020
Y1 - 2020
N2 - Studies on sugar intake and its link to cardiometabolic risk show inconsistent results, partly due to dietary misreporting. Cost-effective and easily measured nutritional biomarkers that can complement dietary data are warranted. Measurement of 24-h urinary sugars is a biomarker of sugar intake, but there are knowledge gaps regarding the use of overnight urine samples. We aim to compare (1) overnight urinary sucrose and fructose measured with liquid chromatography-tandem mass spectrometry, (2) self-reported sugar intake measured with web-based 4-day food records, (3) their composite measure, and (4) these different measures' (1–3) cross-sectional associations with cardiometabolic risk factors in 991 adults in the Malmö Offspring Study (18–69 years, 54% women). The correlations between the reported intakes of total sugar, added sugar and sucrose was higher for urinary sucrose than fructose, and the correlations for the sum or urinary sucrose and fructose (U-sugars) varied between r≈0.2–0.3 (P < 0.01) in men and women. Differences in the direction of associations were observed for some cardiometabolic risk factors between U-sugars and reported added sugar intake, as well as between the sexes. In women, U-sugars, but not reported added sugar intake, were positively associated with systolic and diastolic blood pressure and fasting glucose. Both U-sugars and added sugar were positively associated with BMI and waist circumference in women, whereas among men, U-sugars were negatively associated with BMI and waist circumference, and no association was observed for added sugar. The composite measure of added sugars and U-sugars was positively associated with BMI, waist circumference and systolic blood pressure and negatively associated with HDL cholesterol in women (P < 0.05). Conclusively, we demonstrate statistically significant, but not very high, correlations between reported sugar intakes and U-sugars. Results indicate that overnight urinary sugars may be used as a complement to self-reported dietary data when investigating associations between sugar exposure and cardiometabolic risk. However, future studies are highly needed to validate the overnight urinary sugars as a biomarker because its use, instead of 24-h urine, facilitates data collection.
AB - Studies on sugar intake and its link to cardiometabolic risk show inconsistent results, partly due to dietary misreporting. Cost-effective and easily measured nutritional biomarkers that can complement dietary data are warranted. Measurement of 24-h urinary sugars is a biomarker of sugar intake, but there are knowledge gaps regarding the use of overnight urine samples. We aim to compare (1) overnight urinary sucrose and fructose measured with liquid chromatography-tandem mass spectrometry, (2) self-reported sugar intake measured with web-based 4-day food records, (3) their composite measure, and (4) these different measures' (1–3) cross-sectional associations with cardiometabolic risk factors in 991 adults in the Malmö Offspring Study (18–69 years, 54% women). The correlations between the reported intakes of total sugar, added sugar and sucrose was higher for urinary sucrose than fructose, and the correlations for the sum or urinary sucrose and fructose (U-sugars) varied between r≈0.2–0.3 (P < 0.01) in men and women. Differences in the direction of associations were observed for some cardiometabolic risk factors between U-sugars and reported added sugar intake, as well as between the sexes. In women, U-sugars, but not reported added sugar intake, were positively associated with systolic and diastolic blood pressure and fasting glucose. Both U-sugars and added sugar were positively associated with BMI and waist circumference in women, whereas among men, U-sugars were negatively associated with BMI and waist circumference, and no association was observed for added sugar. The composite measure of added sugars and U-sugars was positively associated with BMI, waist circumference and systolic blood pressure and negatively associated with HDL cholesterol in women (P < 0.05). Conclusively, we demonstrate statistically significant, but not very high, correlations between reported sugar intakes and U-sugars. Results indicate that overnight urinary sugars may be used as a complement to self-reported dietary data when investigating associations between sugar exposure and cardiometabolic risk. However, future studies are highly needed to validate the overnight urinary sugars as a biomarker because its use, instead of 24-h urine, facilitates data collection.
KW - added sugar intake
KW - cardiometabolic risk factors
KW - nutritional biomarkers
KW - overnight urinary sugars
KW - urinary sucrose and fructose
U2 - 10.3389/fnut.2020.00062
DO - 10.3389/fnut.2020.00062
M3 - Journal article
AN - SCOPUS:85085181768
VL - 7
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
SN - 2296-861X
M1 - 62
ER -
ID: 288801144