Administration of a dipeptidyl peptidase IV inhibitor enhances the intestinal adaptation in a mouse model of short bowel syndrome
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Administration of a dipeptidyl peptidase IV inhibitor enhances the intestinal adaptation in a mouse model of short bowel syndrome. / Okawada, Manabu; Holst, Jens Juul; Teitelbaum, Daniel H.
In: Surgery, Vol. 150, No. 2, 08.2011, p. 217-223.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Administration of a dipeptidyl peptidase IV inhibitor enhances the intestinal adaptation in a mouse model of short bowel syndrome
AU - Okawada, Manabu
AU - Holst, Jens Juul
AU - Teitelbaum, Daniel H
N1 - Copyright © 2011 Mosby, Inc. All rights reserved.
PY - 2011/8
Y1 - 2011/8
N2 - Glucagon-like peptide-2 induces small intestine mucosal epithelial cell proliferation and may have benefit for patients who suffer from short bowel syndrome. However, glucagon-like peptide-2 is inactivated rapidly in vivo by dipeptidyl peptidase IV. Therefore, we hypothesized that selectively inhibiting dipeptidyl peptidase IV would prolong the circulating life of glucagon-like peptide-2 and lead to increased intestinal adaptation after development of short bowel syndrome.
AB - Glucagon-like peptide-2 induces small intestine mucosal epithelial cell proliferation and may have benefit for patients who suffer from short bowel syndrome. However, glucagon-like peptide-2 is inactivated rapidly in vivo by dipeptidyl peptidase IV. Therefore, we hypothesized that selectively inhibiting dipeptidyl peptidase IV would prolong the circulating life of glucagon-like peptide-2 and lead to increased intestinal adaptation after development of short bowel syndrome.
KW - Adaptation, Physiological
KW - Animals
KW - Dipeptidyl-Peptidase IV Inhibitors
KW - Disease Models, Animal
KW - Glucagon-Like Peptide 2
KW - Intestine, Small
KW - Mice
KW - Mice, Inbred C57BL
KW - Short Bowel Syndrome
U2 - 10.1016/j.surg.2011.05.013
DO - 10.1016/j.surg.2011.05.013
M3 - Journal article
C2 - 21719060
VL - 150
SP - 217
EP - 223
JO - Surgery
JF - Surgery
SN - 0263-9319
IS - 2
ER -
ID: 38433225