Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients. / Yabe, Daisuke; Kuroe, Akira; Watanabe, Koin; Iwasaki, Masahiro; Hamasaki, Akihiro; Hamamoto, Yoshiyuki; Harada, Norio; Yamane, Shunsuke; Lee, Soushou; Murotani, Kenta; Deacon, Carolyn F; Holst, Jens Juul; Hirano, Tsutomu; Inagaki, Nobuya; Kurose, Takeshi; Seino, Yutaka.
In: Journal of Diabetes and its Complications, Vol. 29, 2015, p. 413-421.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients
AU - Yabe, Daisuke
AU - Kuroe, Akira
AU - Watanabe, Koin
AU - Iwasaki, Masahiro
AU - Hamasaki, Akihiro
AU - Hamamoto, Yoshiyuki
AU - Harada, Norio
AU - Yamane, Shunsuke
AU - Lee, Soushou
AU - Murotani, Kenta
AU - Deacon, Carolyn F
AU - Holst, Jens Juul
AU - Hirano, Tsutomu
AU - Inagaki, Nobuya
AU - Kurose, Takeshi
AU - Seino, Yutaka
N1 - Copyright © 2015. Published by Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - AIMS: Hypersecretion of glucagon and reduced insulin secretion both contribute to hyperglycemia in type 2 diabetes (T2DM). However, the relative contributions of impaired glucagon and insulin secretions in glucose excursions at the various stages of T2DM development remain to be determined.METHODS: The responses of glucagon and insulin as well as those of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) were examined before and after ingestion of glucose or mixed meal in Japanese subjects with normal or impaired glucose tolerance (NGT and IGT) and in non-obese, untreated T2DM of short duration.RESULTS: In OGTT, T2DM showed a rise in glucagon at 0-30min, unlike NGT and IGT, along with reduced insulin. In MTT, all three groups showed a rise in glucagon at 0-30min, with that in T2DM being highest, while T2DM showed a significant reduction in insulin. Linear regression analyses revealed that glucose area under the curve (AUC)0-120 min was associated with glucagon-AUC0-30 min and insulin-AUC0-30 min in both OGTT and MTT. Total and biologically intact GIP and GLP-1 levels were similar among the three groups.CONCLUSIONS: Disordered early phase insulin and glucagon secretions but not incretin secretion are involved in hyperglycemia after ingestion of nutrients in T2DM of even a short duration.
AB - AIMS: Hypersecretion of glucagon and reduced insulin secretion both contribute to hyperglycemia in type 2 diabetes (T2DM). However, the relative contributions of impaired glucagon and insulin secretions in glucose excursions at the various stages of T2DM development remain to be determined.METHODS: The responses of glucagon and insulin as well as those of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) were examined before and after ingestion of glucose or mixed meal in Japanese subjects with normal or impaired glucose tolerance (NGT and IGT) and in non-obese, untreated T2DM of short duration.RESULTS: In OGTT, T2DM showed a rise in glucagon at 0-30min, unlike NGT and IGT, along with reduced insulin. In MTT, all three groups showed a rise in glucagon at 0-30min, with that in T2DM being highest, while T2DM showed a significant reduction in insulin. Linear regression analyses revealed that glucose area under the curve (AUC)0-120 min was associated with glucagon-AUC0-30 min and insulin-AUC0-30 min in both OGTT and MTT. Total and biologically intact GIP and GLP-1 levels were similar among the three groups.CONCLUSIONS: Disordered early phase insulin and glucagon secretions but not incretin secretion are involved in hyperglycemia after ingestion of nutrients in T2DM of even a short duration.
U2 - 10.1016/j.jdiacomp.2014.12.010
DO - 10.1016/j.jdiacomp.2014.12.010
M3 - Journal article
C2 - 25613093
VL - 29
SP - 413
EP - 421
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
ER -
ID: 132046701