Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes
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Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes. / Lodefalk, M; Carlsson-Skwirut, C; Holst, Jens Juul; Aman, J; Bang, P.
In: Hormone research in pædiatrics, Vol. 73, No. 5, 01.01.2010, p. 355-362.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes
AU - Lodefalk, M
AU - Carlsson-Skwirut, C
AU - Holst, Jens Juul
AU - Aman, J
AU - Bang, P.
N1 - Copyright 2010 S. Karger AG, Basel.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Aims: To compare the responses of GIP, GLP-1, ghrelin and IGFBP-1 between meals with different fat and energy content in adolescents with type 1 diabetes (T1DM) and to relate them to gastric emptying and glycaemia. Methods: On different days and in a random order, 7 adolescents with T1DM ingested a high- and low-fat meal (fat content: 38 and 2 g, energy content: 640 and 320 kcal, respectively). At normoglycaemia, the same prandial insulin dose was given at both meals and to all subjects. Postprandial blood samples were taken repeatedly over 4 hours. Gastric emptying was estimated by the paracetamol absorption method. Results: The area under the curve (AUC) for GIP(0-240 min) and for GLP-1(0-120 min) was larger, but smaller for relative ghrelin(0-240 min), after the high-fat meal (p = 0.002, 0.030 and 0.043, respectively). IGFBP-1 decreased significantly, but not differently, after the meals. Larger GLP-1 secretion correlated with slower gastric emptying (p = 0.029) and higher fasting ghrelin levels correlated with lower postprandial glycaemia (p = 0.007). Conclusion: In adolescents with T1DM, the postprandial responses of GIP, GLP-1 and ghrelin, but not that of IGFBP-1, depend more on meal size than on insulin.
AB - Aims: To compare the responses of GIP, GLP-1, ghrelin and IGFBP-1 between meals with different fat and energy content in adolescents with type 1 diabetes (T1DM) and to relate them to gastric emptying and glycaemia. Methods: On different days and in a random order, 7 adolescents with T1DM ingested a high- and low-fat meal (fat content: 38 and 2 g, energy content: 640 and 320 kcal, respectively). At normoglycaemia, the same prandial insulin dose was given at both meals and to all subjects. Postprandial blood samples were taken repeatedly over 4 hours. Gastric emptying was estimated by the paracetamol absorption method. Results: The area under the curve (AUC) for GIP(0-240 min) and for GLP-1(0-120 min) was larger, but smaller for relative ghrelin(0-240 min), after the high-fat meal (p = 0.002, 0.030 and 0.043, respectively). IGFBP-1 decreased significantly, but not differently, after the meals. Larger GLP-1 secretion correlated with slower gastric emptying (p = 0.029) and higher fasting ghrelin levels correlated with lower postprandial glycaemia (p = 0.007). Conclusion: In adolescents with T1DM, the postprandial responses of GIP, GLP-1 and ghrelin, but not that of IGFBP-1, depend more on meal size than on insulin.
KW - Adolescent
KW - Area Under Curve
KW - Blood Glucose
KW - Diabetes Mellitus, Type 1
KW - Dietary Fats
KW - Energy Intake
KW - Female
KW - Gastric Emptying
KW - Gastric Inhibitory Polypeptide
KW - Ghrelin
KW - Glucagon-Like Peptide 1
KW - Humans
KW - Insulin
KW - Insulin-Like Growth Factor Binding Protein 1
KW - Male
KW - Pilot Projects
KW - Postprandial Period
U2 - 10.1159/000308168
DO - 10.1159/000308168
M3 - Journal article
C2 - 20389106
VL - 73
SP - 355
EP - 362
JO - Hormone Research in Paediatrics
JF - Hormone Research in Paediatrics
SN - 1663-2818
IS - 5
ER -
ID: 33939908