Higher Endogenous Glucose Production during OGTT vs Isoglycemic Intravenous Glucose Infusion
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Higher Endogenous Glucose Production during OGTT vs Isoglycemic Intravenous Glucose Infusion. / Lund, Asger; Bagger, Jonatan I; Christensen, Mikkel Bring; Grøndahl, Magnus; van Hall, Gerrit; Holst, Jens J; Lauritsen, Tina Vilsbøll; Knop, Filip K.
In: The Journal of Clinical Endocrinology & Metabolism, Vol. 101, No. 11, 11.2016, p. 4377-4384.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Higher Endogenous Glucose Production during OGTT vs Isoglycemic Intravenous Glucose Infusion
AU - Lund, Asger
AU - Bagger, Jonatan I
AU - Christensen, Mikkel Bring
AU - Grøndahl, Magnus
AU - van Hall, Gerrit
AU - Holst, Jens J
AU - Lauritsen, Tina Vilsbøll
AU - Knop, Filip K
PY - 2016/11
Y1 - 2016/11
N2 - CONTEXT: Oral glucose ingestion elicits a larger insulin response and delayed suppression of glucagon compared to isoglycemic intravenous (iv) glucose infusion (IIGI).OBJECTIVE: We studied whether these differences translate into effects on endogenous glucose production (EGP) and glucose disposal in patients with type 2 diabetes and non-diabetic control subjects.DESIGN: Single-blinded, randomized, crossover study.SETTING: The study was conducted at a specialized research unit.PARTICIPANTS: Ten patients with type 2 diabetes (age [mean ± SD] 57.1 ± 6.7 years; body mass index (BMI) 29.0 ± 4.3 kg/m(2); HbA1c 53.8 ± 11.0 mmol/mol; duration of diabetes 9.2 ± 5.0 years) and 10 matched non-diabetic control subjects (age 56.0±10.7 years; BMI 29.8 ± 2.9 kg/m(2); HbA1c 33.8 ± 5.5 mmol/mol) Interventions: Three experimental days: 75 g-oral glucose tolerance test (OGTT), IIGI and IIGI+glucagon (IIGI with a concomitant iv glucagon infusion (0.8 ng/kg/min from 0 to 25 min) designed to mimic portal glucagon concentrations during OGTT in the type 2 diabetic group).MAIN OUTCOME MEASURES: Glucose kinetics assessed by the double-tracer technique.RESULTS: Glucose rate of disappearance was higher during the OGTT vs IIGIs in the control group, but similar on all days in the diabetic group. Surprisingly, in both groups, EGP was more suppressed during IIGI than during OGTT and exogenous glucagon infusion during IIGI did not restore EGP to the levels observed during OGTT.CONCLUSION: EGP was less suppressed during OGTT than during IIGI in both patients with type 2 diabetes and in non-diabetic control subjects. Based on the present experimental design it was not possible to attribute this difference to the delayed glucagon suppression observed in the initial phase of the OGTT.
AB - CONTEXT: Oral glucose ingestion elicits a larger insulin response and delayed suppression of glucagon compared to isoglycemic intravenous (iv) glucose infusion (IIGI).OBJECTIVE: We studied whether these differences translate into effects on endogenous glucose production (EGP) and glucose disposal in patients with type 2 diabetes and non-diabetic control subjects.DESIGN: Single-blinded, randomized, crossover study.SETTING: The study was conducted at a specialized research unit.PARTICIPANTS: Ten patients with type 2 diabetes (age [mean ± SD] 57.1 ± 6.7 years; body mass index (BMI) 29.0 ± 4.3 kg/m(2); HbA1c 53.8 ± 11.0 mmol/mol; duration of diabetes 9.2 ± 5.0 years) and 10 matched non-diabetic control subjects (age 56.0±10.7 years; BMI 29.8 ± 2.9 kg/m(2); HbA1c 33.8 ± 5.5 mmol/mol) Interventions: Three experimental days: 75 g-oral glucose tolerance test (OGTT), IIGI and IIGI+glucagon (IIGI with a concomitant iv glucagon infusion (0.8 ng/kg/min from 0 to 25 min) designed to mimic portal glucagon concentrations during OGTT in the type 2 diabetic group).MAIN OUTCOME MEASURES: Glucose kinetics assessed by the double-tracer technique.RESULTS: Glucose rate of disappearance was higher during the OGTT vs IIGIs in the control group, but similar on all days in the diabetic group. Surprisingly, in both groups, EGP was more suppressed during IIGI than during OGTT and exogenous glucagon infusion during IIGI did not restore EGP to the levels observed during OGTT.CONCLUSION: EGP was less suppressed during OGTT than during IIGI in both patients with type 2 diabetes and in non-diabetic control subjects. Based on the present experimental design it was not possible to attribute this difference to the delayed glucagon suppression observed in the initial phase of the OGTT.
U2 - 10.1210/jc.2016-1948
DO - 10.1210/jc.2016-1948
M3 - Journal article
C2 - 27533305
VL - 101
SP - 4377
EP - 4384
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 11
ER -
ID: 165935915