Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects. / Hansen, Katrine B; Vilsbøll, Tina; Bagger, Jonatan I; Holst, Jens Juul; Knop, Filip K.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 4, 2012, p. 1363-70.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects
AU - Hansen, Katrine B
AU - Vilsbøll, Tina
AU - Bagger, Jonatan I
AU - Holst, Jens Juul
AU - Knop, Filip K
PY - 2012
Y1 - 2012
N2 - The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.
AB - The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.
KW - Adult
KW - Blood Glucose
KW - C-Peptide
KW - Gastric Inhibitory Polypeptide
KW - Glucagon
KW - Glucagon-Like Peptide 1
KW - Glucose Clamp Technique
KW - Glucose Intolerance
KW - Glucose Tolerance Test
KW - Humans
KW - Incretins
KW - Infusions, Intravenous
KW - Insulin
KW - Insulin Resistance
KW - Insulin-Secreting Cells
KW - Kinetics
KW - Male
KW - Severity of Illness Index
KW - Young Adult
U2 - 10.1210/jc.2011-2594
DO - 10.1210/jc.2011-2594
M3 - Journal article
C2 - 22319034
VL - 97
SP - 1363
EP - 1370
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -
ID: 40379513