Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation?
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Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects : a possible link between obesity and local tissue inflammation? / Arngrim, N; Simonsen, L; Holst, Jens Juul; Bülow, J.
In: International Journal of Obesity, Vol. 37, 2012, p. 748-50.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects
T2 - a possible link between obesity and local tissue inflammation?
AU - Arngrim, N
AU - Simonsen, L
AU - Holst, Jens Juul
AU - Bülow, J
PY - 2012
Y1 - 2012
N2 - The aim of this study was to investigate subcutaneous adipose tissue lymphatic drainage (ATLD) of macromolecules in lean and obese subjects and, furthermore, to evaluate whether ATLD may change in parallel with adipose tissue blood flow. Lean and obese male subjects were studied before and after an oral glucose load. Adipose-tissue blood flow was measured in the anterior subcutaneous abdominal adipose tissue by the (133)Xe-washout technique. ATLD was measured as the disappearance rate of (99m)Tc-labelled nanoaggregated human albumin, during fasting and after an oral glucose load. A significant increase in ATLD was seen after the glucose load in the lean subjects. In the obese subjects, ATLD remained constant throughout the study and was significantly lower compared to the lean subjects. These results indicate a reduced ability to remove macromolecules from the interstitial space through the lymphatic system in obese subjects. Furthermore, they suggest that postprandial changes in ATLD taking place in lean subjects are not observed in obese subjects. This may have a role in the development of obesity-related inflammation in hypertrophic adipose tissue.International Journal of Obesity advance online publication, 3 July 2012; doi:10.1038/ijo.2012.98.
AB - The aim of this study was to investigate subcutaneous adipose tissue lymphatic drainage (ATLD) of macromolecules in lean and obese subjects and, furthermore, to evaluate whether ATLD may change in parallel with adipose tissue blood flow. Lean and obese male subjects were studied before and after an oral glucose load. Adipose-tissue blood flow was measured in the anterior subcutaneous abdominal adipose tissue by the (133)Xe-washout technique. ATLD was measured as the disappearance rate of (99m)Tc-labelled nanoaggregated human albumin, during fasting and after an oral glucose load. A significant increase in ATLD was seen after the glucose load in the lean subjects. In the obese subjects, ATLD remained constant throughout the study and was significantly lower compared to the lean subjects. These results indicate a reduced ability to remove macromolecules from the interstitial space through the lymphatic system in obese subjects. Furthermore, they suggest that postprandial changes in ATLD taking place in lean subjects are not observed in obese subjects. This may have a role in the development of obesity-related inflammation in hypertrophic adipose tissue.International Journal of Obesity advance online publication, 3 July 2012; doi:10.1038/ijo.2012.98.
U2 - 10.1038/ijo.2012.98
DO - 10.1038/ijo.2012.98
M3 - Journal article
C2 - 22751255
VL - 37
SP - 748
EP - 750
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
ER -
ID: 40128764