Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection

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Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection. / Dahly, Elizabeth M; Gillingham, Melanie B; Guo, Ziwen; Murali, Sangita G; Nelson, David W; Holst, Jens Juul; Ney, Denise M.

In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 284, No. 4, 04.2003, p. G670-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Dahly, EM, Gillingham, MB, Guo, Z, Murali, SG, Nelson, DW, Holst, JJ & Ney, DM 2003, 'Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 284, no. 4, pp. G670-82. https://doi.org/10.1152/ajpgi.00293.2002

APA

Dahly, E. M., Gillingham, M. B., Guo, Z., Murali, S. G., Nelson, D. W., Holst, J. J., & Ney, D. M. (2003). Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection. American Journal of Physiology: Gastrointestinal and Liver Physiology, 284(4), G670-82. https://doi.org/10.1152/ajpgi.00293.2002

Vancouver

Dahly EM, Gillingham MB, Guo Z, Murali SG, Nelson DW, Holst JJ et al. Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2003 Apr;284(4):G670-82. https://doi.org/10.1152/ajpgi.00293.2002

Author

Dahly, Elizabeth M ; Gillingham, Melanie B ; Guo, Ziwen ; Murali, Sangita G ; Nelson, David W ; Holst, Jens Juul ; Ney, Denise M. / Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection. In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 2003 ; Vol. 284, No. 4. pp. G670-82.

Bibtex

@article{4d5df20228af4b56abb718bd546f9e04,
title = "Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection",
abstract = "To elucidate the role of luminal nutrients and glucagon-like peptide-2 (GLP-2) in intestinal adaptation, rats were subjected to 70% midjejunoileal resection or ileal transection and were maintained with total parenteral nutrition (TPN) or oral feeding. TPN rats showed small bowel mucosal hyperplasia at 8 h through 7 days after resection, demonstrating that exogenous luminal nutrients are not essential for resection-induced adaptation when residual ileum and colon are present. Increased enterocyte proliferation was a stronger determinant of resection-induced mucosal growth in orally fed animals, whereas decreased apoptosis showed a greater effect in TPN animals. Resection induced significant transient increases in plasma bioactive GLP-2 during TPN, whereas resection induced sustained increases in plasma GLP-2 during oral feeding. Resection-induced adaptive growth in TPN and orally fed rats was associated with a significant positive correlation between increases in plasma bioactive GLP-2 and proglucagon mRNA expression in the colon of TPN rats and ileum of orally fed rats. These data support a significant role for endogenous GLP-2 in the adaptive response to mid-small bowel resection in both TPN and orally fed rats.",
keywords = "Adaptation, Physiological, Animals, Apoptosis, Body Weight, Cell Division, Eating, Enterocytes, Glucagon, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Ileum, Jejunum, Male, Parenteral Nutrition, Peptides, Proglucagon, Protein Precursors, Rats, Rats, Sprague-Dawley, Sucrase",
author = "Dahly, {Elizabeth M} and Gillingham, {Melanie B} and Ziwen Guo and Murali, {Sangita G} and Nelson, {David W} and Holst, {Jens Juul} and Ney, {Denise M}",
year = "2003",
month = apr,
doi = "10.1152/ajpgi.00293.2002",
language = "English",
volume = "284",
pages = "G670--82",
journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",
issn = "0193-1857",
publisher = "American Physiological Society",
number = "4",

}

RIS

TY - JOUR

T1 - Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection

AU - Dahly, Elizabeth M

AU - Gillingham, Melanie B

AU - Guo, Ziwen

AU - Murali, Sangita G

AU - Nelson, David W

AU - Holst, Jens Juul

AU - Ney, Denise M

PY - 2003/4

Y1 - 2003/4

N2 - To elucidate the role of luminal nutrients and glucagon-like peptide-2 (GLP-2) in intestinal adaptation, rats were subjected to 70% midjejunoileal resection or ileal transection and were maintained with total parenteral nutrition (TPN) or oral feeding. TPN rats showed small bowel mucosal hyperplasia at 8 h through 7 days after resection, demonstrating that exogenous luminal nutrients are not essential for resection-induced adaptation when residual ileum and colon are present. Increased enterocyte proliferation was a stronger determinant of resection-induced mucosal growth in orally fed animals, whereas decreased apoptosis showed a greater effect in TPN animals. Resection induced significant transient increases in plasma bioactive GLP-2 during TPN, whereas resection induced sustained increases in plasma GLP-2 during oral feeding. Resection-induced adaptive growth in TPN and orally fed rats was associated with a significant positive correlation between increases in plasma bioactive GLP-2 and proglucagon mRNA expression in the colon of TPN rats and ileum of orally fed rats. These data support a significant role for endogenous GLP-2 in the adaptive response to mid-small bowel resection in both TPN and orally fed rats.

AB - To elucidate the role of luminal nutrients and glucagon-like peptide-2 (GLP-2) in intestinal adaptation, rats were subjected to 70% midjejunoileal resection or ileal transection and were maintained with total parenteral nutrition (TPN) or oral feeding. TPN rats showed small bowel mucosal hyperplasia at 8 h through 7 days after resection, demonstrating that exogenous luminal nutrients are not essential for resection-induced adaptation when residual ileum and colon are present. Increased enterocyte proliferation was a stronger determinant of resection-induced mucosal growth in orally fed animals, whereas decreased apoptosis showed a greater effect in TPN animals. Resection induced significant transient increases in plasma bioactive GLP-2 during TPN, whereas resection induced sustained increases in plasma GLP-2 during oral feeding. Resection-induced adaptive growth in TPN and orally fed rats was associated with a significant positive correlation between increases in plasma bioactive GLP-2 and proglucagon mRNA expression in the colon of TPN rats and ileum of orally fed rats. These data support a significant role for endogenous GLP-2 in the adaptive response to mid-small bowel resection in both TPN and orally fed rats.

KW - Adaptation, Physiological

KW - Animals

KW - Apoptosis

KW - Body Weight

KW - Cell Division

KW - Eating

KW - Enterocytes

KW - Glucagon

KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Ileum

KW - Jejunum

KW - Male

KW - Parenteral Nutrition

KW - Peptides

KW - Proglucagon

KW - Protein Precursors

KW - Rats

KW - Rats, Sprague-Dawley

KW - Sucrase

U2 - 10.1152/ajpgi.00293.2002

DO - 10.1152/ajpgi.00293.2002

M3 - Journal article

C2 - 12505881

VL - 284

SP - G670-82

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

SN - 0193-1857

IS - 4

ER -

ID: 132056367