Secretion and Impact of Gut Hormones in Obesity and Diabetes
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Secretion and Impact of Gut Hormones in Obesity and Diabetes. / Holst, Jens J.
Encyclopedia of Cell Biology: Systems, Translational and Specialized Cell Aspects of Cell Biology. ed. / Ralph A. Bradshaw; Gerald W. Hart; Philip D. Stahl. Vol. 6 2. ed. Elsevier, 2023. p. 543-550.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Secretion and Impact of Gut Hormones in Obesity and Diabetes
AU - Holst, Jens J.
N1 - Publisher Copyright: © 2023 Elsevier Inc. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Gut hormones, otherwise known for their actions on the gastrointestinal tract, have important roles in the regulation of both metabolism and food intake. Insulin-stimulating incretin hormones, GLP-1 and GIP, are responsible for disposal of up to 80% of an oral glucose load, thereby preventing postprandial hyperglycemia (an established cardiovascular risk factor). Absence of the incretin effect leads to overt glucose intolerance. Gut hormones may influence energy balance which has led to investigation of the possible involvement of these hormones and their secretion in the pathogenesis of these diseases. In this short overview, we will discuss some key observations regarding these features with an emphasis on human conditions.
AB - Gut hormones, otherwise known for their actions on the gastrointestinal tract, have important roles in the regulation of both metabolism and food intake. Insulin-stimulating incretin hormones, GLP-1 and GIP, are responsible for disposal of up to 80% of an oral glucose load, thereby preventing postprandial hyperglycemia (an established cardiovascular risk factor). Absence of the incretin effect leads to overt glucose intolerance. Gut hormones may influence energy balance which has led to investigation of the possible involvement of these hormones and their secretion in the pathogenesis of these diseases. In this short overview, we will discuss some key observations regarding these features with an emphasis on human conditions.
KW - Bariatric surgery
KW - Ghrelin
KW - GIP
KW - Glicentin
KW - Glucagon-like peptide-1. GLP-1
KW - Glucose-dependent insulinotropic polypeptide
KW - LEAP2
KW - Oxyntomodulin
KW - Peptide YY
KW - PYY
U2 - 10.1016/B978-0-12-821618-7.00264-9
DO - 10.1016/B978-0-12-821618-7.00264-9
M3 - Book chapter
AN - SCOPUS:85159031696
SN - 978-0-12-821624-8
VL - 6
SP - 543
EP - 550
BT - Encyclopedia of Cell Biology
A2 - Bradshaw, Ralph A.
A2 - Hart, Gerald W.
A2 - Stahl, Philip D.
PB - Elsevier
ER -
ID: 381509278