The effect of a subcutaneous infusion of GLP-1, OXM and PYY on Energy intake and Expenditure in Obese volunteers
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The effect of a subcutaneous infusion of GLP-1, OXM and PYY on Energy intake and Expenditure in Obese volunteers. / Tan, Tricia; Behary, Preeshila; Tharakan, George; Minnion, James; Al-Najim, Werd; Wewer Albrechtsen, Nicolai J; Holst, Jens J; Bloom, Stephen R.
In: The Journal of clinical endocrinology and metabolism, Vol. 102, No. 7, 01.07.2017, p. 2364-2372.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of a subcutaneous infusion of GLP-1, OXM and PYY on Energy intake and Expenditure in Obese volunteers
AU - Tan, Tricia
AU - Behary, Preeshila
AU - Tharakan, George
AU - Minnion, James
AU - Al-Najim, Werd
AU - Wewer Albrechtsen, Nicolai J
AU - Holst, Jens J
AU - Bloom, Stephen R
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background: Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective treatment for obesity, although limited by availability and operative risk. The gut hormones Glucagon-like peptide-1 (GLP-1), Peptide YY (PYY) and Oxyntomodulin (OXM) are elevated post-prandially after RYGB, which has been postulated to contribute to its metabolic benefits.Objective: We hypothesised that infusion of the three gut hormones to achieve levels similar to those encountered post-prandially in RYGB patients might be effective in suppressing appetite. The aim of this study was to investigate the effect of a continuous infusion of GLP-1, OXM and PYY (GOP) on energy intake and expenditure in obese volunteers.Methods: Obese volunteers were randomised to receive an infusion of GOP or placebo in a single-blinded randomised placebo-controlled cross-over study for 10.5 hours a day. This was delivered subcutaneously using a pump device, allowing volunteers to remain ambulatory. Ad Libitum food intake studies were performed during the infusion and energy expenditure measured using a ventilated hood calorimeter.Results: Post-prandial levels of GLP-1, OXM and PYY seen post RYGB were successfully matched using 4 pmol/kg/min, 4 pmol/kg/min and 0.4 pmol/kg/min respectively. This dose led to a mean reduction of 32% in food intake. No significant effects on resting energy expenditure were observed.Conclusion: This is the first time that an acute continuous subcutaneous infusion of GOP, replicating the post-prandial levels observed after RYGB, is shown to be safe and effective in reducing food intake. This data suggests that triple hormone therapy might be a useful tool against obesity.
AB - Background: Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective treatment for obesity, although limited by availability and operative risk. The gut hormones Glucagon-like peptide-1 (GLP-1), Peptide YY (PYY) and Oxyntomodulin (OXM) are elevated post-prandially after RYGB, which has been postulated to contribute to its metabolic benefits.Objective: We hypothesised that infusion of the three gut hormones to achieve levels similar to those encountered post-prandially in RYGB patients might be effective in suppressing appetite. The aim of this study was to investigate the effect of a continuous infusion of GLP-1, OXM and PYY (GOP) on energy intake and expenditure in obese volunteers.Methods: Obese volunteers were randomised to receive an infusion of GOP or placebo in a single-blinded randomised placebo-controlled cross-over study for 10.5 hours a day. This was delivered subcutaneously using a pump device, allowing volunteers to remain ambulatory. Ad Libitum food intake studies were performed during the infusion and energy expenditure measured using a ventilated hood calorimeter.Results: Post-prandial levels of GLP-1, OXM and PYY seen post RYGB were successfully matched using 4 pmol/kg/min, 4 pmol/kg/min and 0.4 pmol/kg/min respectively. This dose led to a mean reduction of 32% in food intake. No significant effects on resting energy expenditure were observed.Conclusion: This is the first time that an acute continuous subcutaneous infusion of GOP, replicating the post-prandial levels observed after RYGB, is shown to be safe and effective in reducing food intake. This data suggests that triple hormone therapy might be a useful tool against obesity.
KW - Journal Article
U2 - 10.1210/jc.2017-00469
DO - 10.1210/jc.2017-00469
M3 - Journal article
C2 - 28379519
VL - 102
SP - 2364
EP - 2372
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 7
ER -
ID: 183005801