The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies
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The role of GLP-1 in postprandial glucose metabolism after bariatric surgery : a narrative review of human GLP-1 receptor antagonist studies. / Hindsø, Morten; Svane, Maria S; Hedbäck, Nora; Holst, Jens J; Madsbad, Sten; Bojsen-Møller, Kirstine N.
In: Surgery for Obesity and Related Diseases, Vol. 17, No. 7, 2021, p. 1383-1391.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The role of GLP-1 in postprandial glucose metabolism after bariatric surgery
T2 - a narrative review of human GLP-1 receptor antagonist studies
AU - Hindsø, Morten
AU - Svane, Maria S
AU - Hedbäck, Nora
AU - Holst, Jens J
AU - Madsbad, Sten
AU - Bojsen-Møller, Kirstine N.
N1 - Copyright © 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
PY - 2021
Y1 - 2021
N2 - The Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric procedures lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiologic importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated. The effect of GLP-1 receptor blockade after RYGB has been investigated in 12 studies. The studies indicate a shift toward a more prominent role for GLP-1 in postprandial β-cell function after RYGB. The effect of GLP-1 receptor antagonism on glucose tolerance after RYGB is more complex and is associated with important methodological challenges. The postprandial GLP-1 response is less enhanced after SG compared with RYGB. However, the effect of GLP-1 receptor blockade after SG has been examined in 1 study only and needs further investigation.
AB - The Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric procedures lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiologic importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated. The effect of GLP-1 receptor blockade after RYGB has been investigated in 12 studies. The studies indicate a shift toward a more prominent role for GLP-1 in postprandial β-cell function after RYGB. The effect of GLP-1 receptor antagonism on glucose tolerance after RYGB is more complex and is associated with important methodological challenges. The postprandial GLP-1 response is less enhanced after SG compared with RYGB. However, the effect of GLP-1 receptor blockade after SG has been examined in 1 study only and needs further investigation.
U2 - 10.1016/j.soard.2021.01.041
DO - 10.1016/j.soard.2021.01.041
M3 - Review
C2 - 33771461
VL - 17
SP - 1383
EP - 1391
JO - Surgery for Obesity and Related Diseases
JF - Surgery for Obesity and Related Diseases
SN - 1550-7289
IS - 7
ER -
ID: 260351452