The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life

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The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life. / Martikainen, Maria Viola; Keski-Nisula, Leea; Jakupović, Hermina; Karvonen, Anne M.; Pekkanen, Juha; Hirvonen, Maija Riitta; Roponen, Marjut.

In: American Journal of Reproductive Immunology, Vol. 77, No. 3, e12621, 01.03.2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Martikainen, MV, Keski-Nisula, L, Jakupović, H, Karvonen, AM, Pekkanen, J, Hirvonen, MR & Roponen, M 2017, 'The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life', American Journal of Reproductive Immunology, vol. 77, no. 3, e12621. https://doi.org/10.1111/aji.12621

APA

Martikainen, M. V., Keski-Nisula, L., Jakupović, H., Karvonen, A. M., Pekkanen, J., Hirvonen, M. R., & Roponen, M. (2017). The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life. American Journal of Reproductive Immunology, 77(3), [e12621]. https://doi.org/10.1111/aji.12621

Vancouver

Martikainen MV, Keski-Nisula L, Jakupović H, Karvonen AM, Pekkanen J, Hirvonen MR et al. The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life. American Journal of Reproductive Immunology. 2017 Mar 1;77(3). e12621. https://doi.org/10.1111/aji.12621

Author

Martikainen, Maria Viola ; Keski-Nisula, Leea ; Jakupović, Hermina ; Karvonen, Anne M. ; Pekkanen, Juha ; Hirvonen, Maija Riitta ; Roponen, Marjut. / The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life. In: American Journal of Reproductive Immunology. 2017 ; Vol. 77, No. 3.

Bibtex

@article{5457554b9783481a8cb3e4c0d6133a1f,
title = "The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life",
abstract = "Problem: Birth-related factors and neonatal treatments could affect the maturation of immune system and thus have lasting effects on immune responses. We investigated the effect of obstetric factors other than being born by cesarean section on immune responses later in life. Method of Study: Regulatory, inflammatory, TH1 and TH2 cytokines, and a chemokine were analyzed in unstimulated and Toll-like receptors (TLRs) 2-, 3-, and 4-stimulated PBMCs of teenagers born by cesarean delivery (CD; N=79). Data on obstetric factors were collected from patient data archives. Results: Advanced cervical dilatation at the time of CD associated with higher unstimulated production of cytokines compared to adolescents who were delivered before the onset of labor. Neonatal intensive care treatment associated with lower unstimulated production of cytokines. Similar associations were found following TLR stimulations. Conclusion: The lack of natural processes of delivery and neonatal intensive care treatment might lead to long-lasting impairment of immune responses.",
keywords = "cesarean, innate immunity, microbes, obstetric factors, TLR",
author = "Martikainen, {Maria Viola} and Leea Keski-Nisula and Hermina Jakupovi{\'c} and Karvonen, {Anne M.} and Juha Pekkanen and Hirvonen, {Maija Riitta} and Marjut Roponen",
year = "2017",
month = mar,
day = "1",
doi = "10.1111/aji.12621",
language = "English",
volume = "77",
journal = "American Journal of Reproductive Immunology and Microbiology",
issn = "8755-8920",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - The lack of natural processes of delivery and neonatal intensive care treatment lead to impaired cytokine responses later in life

AU - Martikainen, Maria Viola

AU - Keski-Nisula, Leea

AU - Jakupović, Hermina

AU - Karvonen, Anne M.

AU - Pekkanen, Juha

AU - Hirvonen, Maija Riitta

AU - Roponen, Marjut

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Problem: Birth-related factors and neonatal treatments could affect the maturation of immune system and thus have lasting effects on immune responses. We investigated the effect of obstetric factors other than being born by cesarean section on immune responses later in life. Method of Study: Regulatory, inflammatory, TH1 and TH2 cytokines, and a chemokine were analyzed in unstimulated and Toll-like receptors (TLRs) 2-, 3-, and 4-stimulated PBMCs of teenagers born by cesarean delivery (CD; N=79). Data on obstetric factors were collected from patient data archives. Results: Advanced cervical dilatation at the time of CD associated with higher unstimulated production of cytokines compared to adolescents who were delivered before the onset of labor. Neonatal intensive care treatment associated with lower unstimulated production of cytokines. Similar associations were found following TLR stimulations. Conclusion: The lack of natural processes of delivery and neonatal intensive care treatment might lead to long-lasting impairment of immune responses.

AB - Problem: Birth-related factors and neonatal treatments could affect the maturation of immune system and thus have lasting effects on immune responses. We investigated the effect of obstetric factors other than being born by cesarean section on immune responses later in life. Method of Study: Regulatory, inflammatory, TH1 and TH2 cytokines, and a chemokine were analyzed in unstimulated and Toll-like receptors (TLRs) 2-, 3-, and 4-stimulated PBMCs of teenagers born by cesarean delivery (CD; N=79). Data on obstetric factors were collected from patient data archives. Results: Advanced cervical dilatation at the time of CD associated with higher unstimulated production of cytokines compared to adolescents who were delivered before the onset of labor. Neonatal intensive care treatment associated with lower unstimulated production of cytokines. Similar associations were found following TLR stimulations. Conclusion: The lack of natural processes of delivery and neonatal intensive care treatment might lead to long-lasting impairment of immune responses.

KW - cesarean

KW - innate immunity

KW - microbes

KW - obstetric factors

KW - TLR

UR - http://www.scopus.com/inward/record.url?scp=85007545256&partnerID=8YFLogxK

U2 - 10.1111/aji.12621

DO - 10.1111/aji.12621

M3 - Journal article

C2 - 28044379

AN - SCOPUS:85007545256

VL - 77

JO - American Journal of Reproductive Immunology and Microbiology

JF - American Journal of Reproductive Immunology and Microbiology

SN - 8755-8920

IS - 3

M1 - e12621

ER -

ID: 253189204