Birth weight and body composition in young women: a prospective twin study
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Birth weight and body composition in young women : a prospective twin study. / Loos, Ruth J F; Beunen, Gaston; Fagard, Robert; Derom, Catherine; Vlietinck, Robert.
In: The American Journal of Clinical Nutrition, Vol. 75, No. 4, 04.2002, p. 676-82.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Birth weight and body composition in young women
T2 - a prospective twin study
AU - Loos, Ruth J F
AU - Beunen, Gaston
AU - Fagard, Robert
AU - Derom, Catherine
AU - Vlietinck, Robert
PY - 2002/4
Y1 - 2002/4
N2 - BACKGROUND: The intrauterine environment may be critical for the development of obesity. Alternatively, the same genetic factors may influence both birth weight and adult body composition.OBJECTIVE: We evaluated the association between birth weight and adult body composition in female twins, which allowed us to control for maternal and genetic influences.DESIGN: Of 447 twin pairs randomly selected from the East Flanders Prospective Twin Survey, 238 pairs, aged 18-34 y, participated. Adult body mass, height, and lean body mass were measured, and the body mass index (BMI), waist-to-hip ratio, and sum of skinfold thicknesses were calculated. The twins were considered as individuals and pairs.RESULTS: When the twins were considered as individuals, twins who were heavier at birth were taller (3.3 cm/kg greater birth weight) and slightly heavier (1.13 kg/kg greater birth weight) as adults than were lighter twins. They also had more lean body mass and less subcutaneous and abdominal fat at birth. Pairwise comparison showed that for every level of intrapair birth weight difference (> or = 5%, > or = 10%, and > or = 15%), the twin who was heavier at birth was taller in adult life (0.8, 1.2, and 2.0 cm, respectively). When the intrapair birth weight difference exceeded 15%, the heavier twin was also heavier (3.1 +/- 6.08 kg) as an adult than her much lighter sister.CONCLUSION: Birth weight accounts for some of the differences in adult body composition between twins.
AB - BACKGROUND: The intrauterine environment may be critical for the development of obesity. Alternatively, the same genetic factors may influence both birth weight and adult body composition.OBJECTIVE: We evaluated the association between birth weight and adult body composition in female twins, which allowed us to control for maternal and genetic influences.DESIGN: Of 447 twin pairs randomly selected from the East Flanders Prospective Twin Survey, 238 pairs, aged 18-34 y, participated. Adult body mass, height, and lean body mass were measured, and the body mass index (BMI), waist-to-hip ratio, and sum of skinfold thicknesses were calculated. The twins were considered as individuals and pairs.RESULTS: When the twins were considered as individuals, twins who were heavier at birth were taller (3.3 cm/kg greater birth weight) and slightly heavier (1.13 kg/kg greater birth weight) as adults than were lighter twins. They also had more lean body mass and less subcutaneous and abdominal fat at birth. Pairwise comparison showed that for every level of intrapair birth weight difference (> or = 5%, > or = 10%, and > or = 15%), the twin who was heavier at birth was taller in adult life (0.8, 1.2, and 2.0 cm, respectively). When the intrapair birth weight difference exceeded 15%, the heavier twin was also heavier (3.1 +/- 6.08 kg) as an adult than her much lighter sister.CONCLUSION: Birth weight accounts for some of the differences in adult body composition between twins.
KW - Adult
KW - Belgium
KW - Birth Weight
KW - Body Composition
KW - Body Constitution
KW - Body Height
KW - Female
KW - Humans
KW - Prospective Studies
KW - Random Allocation
KW - Registries
KW - Regression Analysis
KW - Twins
U2 - 10.1093/ajcn/75.4.676
DO - 10.1093/ajcn/75.4.676
M3 - Journal article
C2 - 11916753
VL - 75
SP - 676
EP - 682
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -
ID: 258334048