Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice. / Spittaels, K; Van den Haute, C; Van Dorpe, J; Terwel, D; Vandezande, K; Lasrado, R; Bruynseels, K; Irizarry, M; Verhoye, M; Van Lint, J; Vandenheede, J R; Ashton, D; Mercken, M; Loos, R; Hyman, B; Van der Linden, A; Geerts, H; Van Leuven, F.

In: Neuroscience, Vol. 113, No. 4, 2002, p. 797-808.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Spittaels, K, Van den Haute, C, Van Dorpe, J, Terwel, D, Vandezande, K, Lasrado, R, Bruynseels, K, Irizarry, M, Verhoye, M, Van Lint, J, Vandenheede, JR, Ashton, D, Mercken, M, Loos, R, Hyman, B, Van der Linden, A, Geerts, H & Van Leuven, F 2002, 'Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice', Neuroscience, vol. 113, no. 4, pp. 797-808. https://doi.org/10.1016/s0306-4522(02)00236-1

APA

Spittaels, K., Van den Haute, C., Van Dorpe, J., Terwel, D., Vandezande, K., Lasrado, R., Bruynseels, K., Irizarry, M., Verhoye, M., Van Lint, J., Vandenheede, J. R., Ashton, D., Mercken, M., Loos, R., Hyman, B., Van der Linden, A., Geerts, H., & Van Leuven, F. (2002). Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice. Neuroscience, 113(4), 797-808. https://doi.org/10.1016/s0306-4522(02)00236-1

Vancouver

Spittaels K, Van den Haute C, Van Dorpe J, Terwel D, Vandezande K, Lasrado R et al. Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice. Neuroscience. 2002;113(4):797-808. https://doi.org/10.1016/s0306-4522(02)00236-1

Author

Spittaels, K ; Van den Haute, C ; Van Dorpe, J ; Terwel, D ; Vandezande, K ; Lasrado, R ; Bruynseels, K ; Irizarry, M ; Verhoye, M ; Van Lint, J ; Vandenheede, J R ; Ashton, D ; Mercken, M ; Loos, R ; Hyman, B ; Van der Linden, A ; Geerts, H ; Van Leuven, F. / Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice. In: Neuroscience. 2002 ; Vol. 113, No. 4. pp. 797-808.

Bibtex

@article{12019849596a48b593e524ba0d582eba,
title = "Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice",
abstract = "Glycogen synthase kinase-3beta (GSK-3beta) is important in neurogenesis. Here we demonstrate that the kinase influenced post-natal maturation and differentiation of neurons in vivo in transgenic mice that overexpress a constitutively active GSK-3beta[S9A]. Magnetic resonance imaging revealed a reduced volume of the entire brain, concordant with a nearly 20% reduction in wet brain weight. The reduced volume was most prominent for the cerebral cortex, without however, disturbing the normal cortical layering. The resulting compacted architecture was further demonstrated by an increased neuronal density, by reduced size of neuronal cell bodies and of the somatodendritic compartment of pyramidal neurons in the cortex. No evidence for apoptosis was obtained. The marked overall reduction in the level of the microtubule-associated protein 2 in brain and in spinal cord, did not affect the ultrastructure of the microtubular cytoskeleton in the proximal apical dendrites. The overall reduction in size of the entire CNS induced by constitutive active GSK-3beta caused only very subtle changes in the psychomotoric ability of adult and ageing GSK-3beta transgenic mice.",
keywords = "Animals, Animals, Newborn, Brain/enzymology, Female, Glycogen Synthase Kinase 3/biosynthesis, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurons/enzymology, Psychomotor Performance/physiology",
author = "K Spittaels and {Van den Haute}, C and {Van Dorpe}, J and D Terwel and K Vandezande and R Lasrado and K Bruynseels and M Irizarry and M Verhoye and {Van Lint}, J and Vandenheede, {J R} and D Ashton and M Mercken and R Loos and B Hyman and {Van der Linden}, A and H Geerts and {Van Leuven}, F",
note = "Copyright 2002 IBRO",
year = "2002",
doi = "10.1016/s0306-4522(02)00236-1",
language = "English",
volume = "113",
pages = "797--808",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Pergamon Press",
number = "4",

}

RIS

TY - JOUR

T1 - Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice

AU - Spittaels, K

AU - Van den Haute, C

AU - Van Dorpe, J

AU - Terwel, D

AU - Vandezande, K

AU - Lasrado, R

AU - Bruynseels, K

AU - Irizarry, M

AU - Verhoye, M

AU - Van Lint, J

AU - Vandenheede, J R

AU - Ashton, D

AU - Mercken, M

AU - Loos, R

AU - Hyman, B

AU - Van der Linden, A

AU - Geerts, H

AU - Van Leuven, F

N1 - Copyright 2002 IBRO

PY - 2002

Y1 - 2002

N2 - Glycogen synthase kinase-3beta (GSK-3beta) is important in neurogenesis. Here we demonstrate that the kinase influenced post-natal maturation and differentiation of neurons in vivo in transgenic mice that overexpress a constitutively active GSK-3beta[S9A]. Magnetic resonance imaging revealed a reduced volume of the entire brain, concordant with a nearly 20% reduction in wet brain weight. The reduced volume was most prominent for the cerebral cortex, without however, disturbing the normal cortical layering. The resulting compacted architecture was further demonstrated by an increased neuronal density, by reduced size of neuronal cell bodies and of the somatodendritic compartment of pyramidal neurons in the cortex. No evidence for apoptosis was obtained. The marked overall reduction in the level of the microtubule-associated protein 2 in brain and in spinal cord, did not affect the ultrastructure of the microtubular cytoskeleton in the proximal apical dendrites. The overall reduction in size of the entire CNS induced by constitutive active GSK-3beta caused only very subtle changes in the psychomotoric ability of adult and ageing GSK-3beta transgenic mice.

AB - Glycogen synthase kinase-3beta (GSK-3beta) is important in neurogenesis. Here we demonstrate that the kinase influenced post-natal maturation and differentiation of neurons in vivo in transgenic mice that overexpress a constitutively active GSK-3beta[S9A]. Magnetic resonance imaging revealed a reduced volume of the entire brain, concordant with a nearly 20% reduction in wet brain weight. The reduced volume was most prominent for the cerebral cortex, without however, disturbing the normal cortical layering. The resulting compacted architecture was further demonstrated by an increased neuronal density, by reduced size of neuronal cell bodies and of the somatodendritic compartment of pyramidal neurons in the cortex. No evidence for apoptosis was obtained. The marked overall reduction in the level of the microtubule-associated protein 2 in brain and in spinal cord, did not affect the ultrastructure of the microtubular cytoskeleton in the proximal apical dendrites. The overall reduction in size of the entire CNS induced by constitutive active GSK-3beta caused only very subtle changes in the psychomotoric ability of adult and ageing GSK-3beta transgenic mice.

KW - Animals

KW - Animals, Newborn

KW - Brain/enzymology

KW - Female

KW - Glycogen Synthase Kinase 3/biosynthesis

KW - Humans

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Neurons/enzymology

KW - Psychomotor Performance/physiology

U2 - 10.1016/s0306-4522(02)00236-1

DO - 10.1016/s0306-4522(02)00236-1

M3 - Journal article

C2 - 12182887

VL - 113

SP - 797

EP - 808

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 4

ER -

ID: 258333362