The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring

Research output: Contribution to journal › Journal article › Research › peer-review

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The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring. / Loos, Ruth J F; Phillips, David I W; Fagard, Robert; Beunen, Gaston; Derom, Catherine; Mathieu, Chantal; Verhaeghe, Johan; Vlietinck, Robert.

In: Diabetes Care. Supplement, Vol. 25, No. 12, 12.2002, p. 2191-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Loos, RJF, Phillips, DIW, Fagard, R, Beunen, G, Derom, C, Mathieu, C, Verhaeghe, J & Vlietinck, R 2002, 'The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring', Diabetes Care. Supplement, vol. 25, no. 12, pp. 2191-6. https://doi.org/10.2337/diacare.25.12.2191

APA

Loos, R. J. F., Phillips, D. I. W., Fagard, R., Beunen, G., Derom, C., Mathieu, C., Verhaeghe, J., & Vlietinck, R. (2002). The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring. Diabetes Care. Supplement, 25(12), 2191-6. https://doi.org/10.2337/diacare.25.12.2191

Vancouver

Loos RJF, Phillips DIW, Fagard R, Beunen G, Derom C, Mathieu C et al. The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring. Diabetes Care. Supplement. 2002 Dec;25(12):2191-6. https://doi.org/10.2337/diacare.25.12.2191

Author

Loos, Ruth J F ; Phillips, David I W ; Fagard, Robert ; Beunen, Gaston ; Derom, Catherine ; Mathieu, Chantal ; Verhaeghe, Johan ; Vlietinck, Robert. / The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring. In: Diabetes Care. Supplement. 2002 ; Vol. 25, No. 12. pp. 2191-6.

Bibtex

@article{14f57b5e1aa8469f981db00e7cd4d6f0,
title = "The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring",
abstract = "OBJECTIVE: There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. We have carried out a twin study to distinguish among maternal influences, which affect both twins; fetoplacental influences, which are unique to each twin; and the genetic factors that may underlie this association.RESEARCH DESIGN AND METHODS: We identified a sample of 423 twin pairs (250 monozygotic and 173 dizygotic) from the East Flanders Prospective Twin Survey who were born between 1964 and 1982. Data collected in this study included the mother's body composition and weight gain during pregnancy, the twins' birth weights, and gestational age. The twins (aged 18-34 years) attended a research center for measurement of height, weight, and waist-to-hip ratio as well as fasting glucose, proinsulin, and insulin concentrations.RESULTS: Among twin pairs discordant for birth weight, we found little evidence that the lighter twin had abnormal glucose-insulin metabolism in adult life. However, both a low prepregnancy maternal BMI and older maternal age at delivery were associated with hyperinsulinemia and evidence of insulin resistance in the offspring. Fasting insulin increased by 1.3% (95% CI 0.1-2.6%) per unit fall in maternal BMI and by 1.1% (0.02-2.0%) per year increase in maternal age. These associations were independent of the twins' BMI and waist-to-hip ratio and their zygosity.CONCLUSIONS: These novel findings suggest that in twin pregnancies, maternal factors are more important than fetoplacental factors in determining glucose-insulin metabolism in the offspring.",
keywords = "Adult, Birth Weight, Body Composition, Body Mass Index, Fasting, Female, Gestational Age, Humans, Infant, Low Birth Weight, Infant, Newborn, Insulin/blood, Insulin Resistance, Islets of Langerhans/metabolism, Maternal Age, Pregnancy/physiology, Pregnancy, High-Risk, Twins, Dizygotic, Twins, Monozygotic, Weight Gain",
author = "Loos, {Ruth J F} and Phillips, {David I W} and Robert Fagard and Gaston Beunen and Catherine Derom and Chantal Mathieu and Johan Verhaeghe and Robert Vlietinck",
year = "2002",
month = dec,
doi = "10.2337/diacare.25.12.2191",
language = "English",
volume = "25",
pages = "2191--6",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association",
number = "12",

}

RIS

TY - JOUR

T1 - The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring

AU - Loos, Ruth J F

AU - Phillips, David I W

AU - Fagard, Robert

AU - Beunen, Gaston

AU - Derom, Catherine

AU - Mathieu, Chantal

AU - Verhaeghe, Johan

AU - Vlietinck, Robert

PY - 2002/12

Y1 - 2002/12

N2 - OBJECTIVE: There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. We have carried out a twin study to distinguish among maternal influences, which affect both twins; fetoplacental influences, which are unique to each twin; and the genetic factors that may underlie this association.RESEARCH DESIGN AND METHODS: We identified a sample of 423 twin pairs (250 monozygotic and 173 dizygotic) from the East Flanders Prospective Twin Survey who were born between 1964 and 1982. Data collected in this study included the mother's body composition and weight gain during pregnancy, the twins' birth weights, and gestational age. The twins (aged 18-34 years) attended a research center for measurement of height, weight, and waist-to-hip ratio as well as fasting glucose, proinsulin, and insulin concentrations.RESULTS: Among twin pairs discordant for birth weight, we found little evidence that the lighter twin had abnormal glucose-insulin metabolism in adult life. However, both a low prepregnancy maternal BMI and older maternal age at delivery were associated with hyperinsulinemia and evidence of insulin resistance in the offspring. Fasting insulin increased by 1.3% (95% CI 0.1-2.6%) per unit fall in maternal BMI and by 1.1% (0.02-2.0%) per year increase in maternal age. These associations were independent of the twins' BMI and waist-to-hip ratio and their zygosity.CONCLUSIONS: These novel findings suggest that in twin pregnancies, maternal factors are more important than fetoplacental factors in determining glucose-insulin metabolism in the offspring.

AB - OBJECTIVE: There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. We have carried out a twin study to distinguish among maternal influences, which affect both twins; fetoplacental influences, which are unique to each twin; and the genetic factors that may underlie this association.RESEARCH DESIGN AND METHODS: We identified a sample of 423 twin pairs (250 monozygotic and 173 dizygotic) from the East Flanders Prospective Twin Survey who were born between 1964 and 1982. Data collected in this study included the mother's body composition and weight gain during pregnancy, the twins' birth weights, and gestational age. The twins (aged 18-34 years) attended a research center for measurement of height, weight, and waist-to-hip ratio as well as fasting glucose, proinsulin, and insulin concentrations.RESULTS: Among twin pairs discordant for birth weight, we found little evidence that the lighter twin had abnormal glucose-insulin metabolism in adult life. However, both a low prepregnancy maternal BMI and older maternal age at delivery were associated with hyperinsulinemia and evidence of insulin resistance in the offspring. Fasting insulin increased by 1.3% (95% CI 0.1-2.6%) per unit fall in maternal BMI and by 1.1% (0.02-2.0%) per year increase in maternal age. These associations were independent of the twins' BMI and waist-to-hip ratio and their zygosity.CONCLUSIONS: These novel findings suggest that in twin pregnancies, maternal factors are more important than fetoplacental factors in determining glucose-insulin metabolism in the offspring.

KW - Adult

KW - Birth Weight

KW - Body Composition

KW - Body Mass Index

KW - Fasting

KW - Female

KW - Gestational Age

KW - Humans

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Insulin/blood

KW - Insulin Resistance

KW - Islets of Langerhans/metabolism

KW - Maternal Age

KW - Pregnancy/physiology

KW - Pregnancy, High-Risk

KW - Twins, Dizygotic

KW - Twins, Monozygotic

KW - Weight Gain

U2 - 10.2337/diacare.25.12.2191

DO - 10.2337/diacare.25.12.2191

M3 - Journal article

C2 - 12453959

VL - 25

SP - 2191

EP - 2196

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 12

ER -

ID: 258333988