Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population

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Standard

Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. / Li, Huaixing; Wu, Ying; Loos, Ruth J F; Hu, Frank B; Liu, Yong; Wang, Jing; Yu, Zhijie; Lin, Xu.

In: Diabetes, Vol. 57, No. 1, 01.2008, p. 264-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, H, Wu, Y, Loos, RJF, Hu, FB, Liu, Y, Wang, J, Yu, Z & Lin, X 2008, 'Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population', Diabetes, vol. 57, no. 1, pp. 264-8. https://doi.org/10.2337/db07-1130

APA

Li, H., Wu, Y., Loos, R. J. F., Hu, F. B., Liu, Y., Wang, J., Yu, Z., & Lin, X. (2008). Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes, 57(1), 264-8. https://doi.org/10.2337/db07-1130

Vancouver

Li H, Wu Y, Loos RJF, Hu FB, Liu Y, Wang J et al. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes. 2008 Jan;57(1):264-8. https://doi.org/10.2337/db07-1130

Author

Li, Huaixing ; Wu, Ying ; Loos, Ruth J F ; Hu, Frank B ; Liu, Yong ; Wang, Jing ; Yu, Zhijie ; Lin, Xu. / Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. In: Diabetes. 2008 ; Vol. 57, No. 1. pp. 264-8.

Bibtex

@article{82dc135639cb452b8fa9d764cd3ccd30,
title = "Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population",
abstract = "OBJECTIVE: Recently, genome-wide association studies have provided evidence that several common variants within the fat mass-and obesity-associated (FTO) gene were significantly associated with obesity in populations of European origin. However, their effects in other ethnic populations remain to be elucidated.RESEARCH DESIGN AND METHODS: In this study, we examined the association between three FTO variants (rs8050136, rs9939609, and rs9930506) and obesity and related traits in a population-based study of 3,210 unrelated Chinese Han subjects from Shanghai and Beijing. In secondary analyses, we also tested for association with type 2 diabetes and related traits. Logistics regression and generalized linear models were used to test for additive and dominant effects of the risk alleles.RESULTS: The minor allele frequencies of rs8050136, rs9939609, and rs9930506 in our population (0.12, 0.12, and 0.20, respectively) were substantially lower than those observed for populations of European descent (e.g., for CEU population of HapMap: 0.45, 0.48, and 0.45, respectively). Despite our study being sufficiently powered to detect effects similar to those previously reported, none of the FTO SNPs were found to be associated with obesity, overweight, BMI, waist circumference, or body fat percentage. In addition, none of the SNPs exhibited significant associations with fasting levels of plasma glucose, A1C, insulin, or beta-cell function (estimated via homeostasis model assessment) under either an additive or a dominant model in the quantitative trait analyses. Analyses stratified by sex or geographical region did not change these observations.CONCLUSIONS: Our data do not support that the FTO common variants are major contributors of obesity or type 2 diabetes in the Chinese Han population.",
keywords = "Asian Continental Ancestry Group/genetics, China, Diabetes Mellitus, Type 2/genetics, Genetic Variation, Humans, Obesity/epidemiology, Overweight/genetics, Polymorphism, Single Nucleotide, Risk Assessment",
author = "Huaixing Li and Ying Wu and Loos, {Ruth J F} and Hu, {Frank B} and Yong Liu and Jing Wang and Zhijie Yu and Xu Lin",
year = "2008",
month = jan,
doi = "10.2337/db07-1130",
language = "English",
volume = "57",
pages = "264--8",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "1",

}

RIS

TY - JOUR

T1 - Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population

AU - Li, Huaixing

AU - Wu, Ying

AU - Loos, Ruth J F

AU - Hu, Frank B

AU - Liu, Yong

AU - Wang, Jing

AU - Yu, Zhijie

AU - Lin, Xu

PY - 2008/1

Y1 - 2008/1

N2 - OBJECTIVE: Recently, genome-wide association studies have provided evidence that several common variants within the fat mass-and obesity-associated (FTO) gene were significantly associated with obesity in populations of European origin. However, their effects in other ethnic populations remain to be elucidated.RESEARCH DESIGN AND METHODS: In this study, we examined the association between three FTO variants (rs8050136, rs9939609, and rs9930506) and obesity and related traits in a population-based study of 3,210 unrelated Chinese Han subjects from Shanghai and Beijing. In secondary analyses, we also tested for association with type 2 diabetes and related traits. Logistics regression and generalized linear models were used to test for additive and dominant effects of the risk alleles.RESULTS: The minor allele frequencies of rs8050136, rs9939609, and rs9930506 in our population (0.12, 0.12, and 0.20, respectively) were substantially lower than those observed for populations of European descent (e.g., for CEU population of HapMap: 0.45, 0.48, and 0.45, respectively). Despite our study being sufficiently powered to detect effects similar to those previously reported, none of the FTO SNPs were found to be associated with obesity, overweight, BMI, waist circumference, or body fat percentage. In addition, none of the SNPs exhibited significant associations with fasting levels of plasma glucose, A1C, insulin, or beta-cell function (estimated via homeostasis model assessment) under either an additive or a dominant model in the quantitative trait analyses. Analyses stratified by sex or geographical region did not change these observations.CONCLUSIONS: Our data do not support that the FTO common variants are major contributors of obesity or type 2 diabetes in the Chinese Han population.

AB - OBJECTIVE: Recently, genome-wide association studies have provided evidence that several common variants within the fat mass-and obesity-associated (FTO) gene were significantly associated with obesity in populations of European origin. However, their effects in other ethnic populations remain to be elucidated.RESEARCH DESIGN AND METHODS: In this study, we examined the association between three FTO variants (rs8050136, rs9939609, and rs9930506) and obesity and related traits in a population-based study of 3,210 unrelated Chinese Han subjects from Shanghai and Beijing. In secondary analyses, we also tested for association with type 2 diabetes and related traits. Logistics regression and generalized linear models were used to test for additive and dominant effects of the risk alleles.RESULTS: The minor allele frequencies of rs8050136, rs9939609, and rs9930506 in our population (0.12, 0.12, and 0.20, respectively) were substantially lower than those observed for populations of European descent (e.g., for CEU population of HapMap: 0.45, 0.48, and 0.45, respectively). Despite our study being sufficiently powered to detect effects similar to those previously reported, none of the FTO SNPs were found to be associated with obesity, overweight, BMI, waist circumference, or body fat percentage. In addition, none of the SNPs exhibited significant associations with fasting levels of plasma glucose, A1C, insulin, or beta-cell function (estimated via homeostasis model assessment) under either an additive or a dominant model in the quantitative trait analyses. Analyses stratified by sex or geographical region did not change these observations.CONCLUSIONS: Our data do not support that the FTO common variants are major contributors of obesity or type 2 diabetes in the Chinese Han population.

KW - Asian Continental Ancestry Group/genetics

KW - China

KW - Diabetes Mellitus, Type 2/genetics

KW - Genetic Variation

KW - Humans

KW - Obesity/epidemiology

KW - Overweight/genetics

KW - Polymorphism, Single Nucleotide

KW - Risk Assessment

U2 - 10.2337/db07-1130

DO - 10.2337/db07-1130

M3 - Journal article

C2 - 17959933

VL - 57

SP - 264

EP - 268

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 1

ER -

ID: 258453495