Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle
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Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle. / Middelbeek, R J W; Chambers, M A; Tantiwong, P; Treebak, Jonas Thue; An, D; Hirshman, M F; Musi, N; Goodyear, L J.
In: Nutrition and Diabetes, Vol. 3, No. 74, 06.2013, p. e74.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle
AU - Middelbeek, R J W
AU - Chambers, M A
AU - Tantiwong, P
AU - Treebak, Jonas Thue
AU - An, D
AU - Hirshman, M F
AU - Musi, N
AU - Goodyear, L J
PY - 2013/6
Y1 - 2013/6
N2 - Individuals with obesity and type 2 diabetes (T2D) are typically insulin resistant, exhibiting impaired skeletal muscle glucose uptake. Animal and cell culture experiments have shown that site-specific phosphorylation of the Rab-GTPase-activating proteins AS160 and TBC1D1 is critical for GLUT4 translocation facilitating glucose uptake, but their regulation in human skeletal muscle is not well understood.
AB - Individuals with obesity and type 2 diabetes (T2D) are typically insulin resistant, exhibiting impaired skeletal muscle glucose uptake. Animal and cell culture experiments have shown that site-specific phosphorylation of the Rab-GTPase-activating proteins AS160 and TBC1D1 is critical for GLUT4 translocation facilitating glucose uptake, but their regulation in human skeletal muscle is not well understood.
U2 - 10.1038/nutd.2013.13
DO - 10.1038/nutd.2013.13
M3 - Journal article
C2 - 23752133
VL - 3
SP - e74
JO - Nutrition and Diabetes
JF - Nutrition and Diabetes
SN - 2044-4052
IS - 74
ER -
ID: 51255343