This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book introduces Art, Science, and Technology Studies (ASTS) as a new field of interdisciplinary inquiry and practice. It also introduces new scholars to this burgeoning area and provides those already familiar with its themes and tensions with a means of connecting across disciplines by proposing organizing principles for thinking about art–science across the sciences, social sciences, humanities, and arts. The book systematizes art and STS and to note features of its methods, institutions, cases, and common themes. It considers the role of audiences and the production of art and science work for public consumption. The part examines the development and display of projects, along with creative works demonstrating some of these ideas. It argues that identified a perceived rift between the arts and sciences and suggested a way in which the two might work together.