Brice Emanuelli

Brice Emanuelli

Associate Professor

ORCID: 0000-0001-5795-5666

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  1. Published

    Immune Cells in Thermogenic Adipose Depots: The Essential but Complex Relationship: Immunomodulation of Thermogenic Fat Depots

    Agueda Oyarzabal, Marina & Emanuelli, Brice, 2022, In: Frontiers in Endocrinology. 13, 9 p., 839360.

    Research output: Contribution to journal › Review › Research › peer-review

  2. Published

    Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes

    Ardenkjær-Larsen, J., Rupar, K., Snieckute, Goda, Petersen, P. S. S., Villarroel, J., Lundh, M., Barrès, Romain, Rabiee, A. & Emanuelli, Brice, 2020, In: Adipocyte (Philadelphia). 9, 1, p. 142-152 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    PPARγ antagonists induce aromatase transcription in adipose tissue cultures

    Ardenkjær-Skinnerup, J., Saar, Daniel, Petersen, Patricia Stephanie S, Pedersen, M., Svingen, T., Kragelund, Birthe Brandt, Hadrup, N., Ravn-Haren, G., Emanuelli, Brice, Brown, K. A. & Vogel, U., 2024, In: Biochemical Pharmacology. 222, 13 p., 116095.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

    Bezy, O., Tran, T. T., Pihlajamäki, J., Suzuki, R., Emanuelli, Brice, Winnay, J., Mori, M. A., Haas, J., Biddinger, S. B., Leitges, M., Goldfine, A. B., Patti, M. E., King, G. L. & Kahn, C. R., Jun 2011, In: The Journal of Clinical Investigation. 121, 6, p. 2504-17 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Insulin resistance in the metabolic syndrome

    Biddinger, S. B. & Emanuelli, Brice, 1 Dec 2011, Metabolic Basis of Obesity. Springer New York LLC, p. 175-198 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  6. Published

    Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

    Brandão, B. B., Madsen, S., Rabiee, A., Oliverio, M., Ruiz, G. P., Ferrucci, D. L., Branquinho, J. L., Razolli, D., Pinto, S., Nielsen, T. S., Festuccia, W. T., Martins, A. S., Guerra, B. A., Knittel, T. L., Søgaard, D., Larsen, S., Helge, J. W., Brandauer, J., Velloso, L. A., Emanuelli, B. & 6 others, Kornfeld, J., Kahn, C. R., Vienberg, S. G., Zierath, Juleen R, Treebak, Jonas Thue & Mori, M. A., 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 38, p. 23932-23941

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

    Emanuelli, Brice, Eberlé, D., Suzuki, R. & Kahn, C. R., 4 Mar 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3545-50 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells

    Emanuelli, Brice, Glondu, M., Filloux, C., Peraldi, P. & Van Obberghen, E., Dec 2004, In: Diabetes. 53 Suppl 3, p. S97-S103

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Interplay between FGF21 and insulin action in the liver regulates metabolism

    Emanuelli, Brice, Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, Mani, Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., Jan 2015, In: The Journal of Clinical Investigation. 125, 1, p. 458

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  10. Published

    Interplay between FGF21 and insulin action in the liver regulates metabolism

    Emanuelli, Brice, Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, Mani, Michael, M. D., Adams, A. C., Kharitonenkov, A. & Kahn, C. R., 3 Feb 2014, In: The Journal of Clinical Investigation. 124, 2, p. 515-27 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

    Emanuelli, Brice, Peraldi, P., Filloux, C., Chavey, C., Freidinger, K., Hilton, D. J., Hotamisligil, G. S. & Van Obberghen, E., 21 Dec 2001, In: Journal of Biological Chemistry. 276, 51, p. 47944-47949 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    SOCS-1 deficiency does not prevent diet-induced insulin resistance

    Emanuelli, Brice, Macotela, Y., Boucher, J. & Ronald Kahn, C., 12 Dec 2008, In: Biochemical and Biophysical Research Communications. 377, 2, p. 447-52 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. SOCS-3 is an insulin-induced negative regulator of insulin signaling

    Emanuelli, Brice, Peraldi, P., Filloux, C., Sawka-Verhelle, D., Hilton, D. & Van Obberghen, E., 26 May 2000, In: Journal of Biological Chemistry. 275, 21, p. 15985-15991 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Identification of two microRNA nodes as potential cooperative modulators of liver metabolism

    Hochreuter, Mette Yde, Altıntaş, Ali, Garde, C., Emanuelli, Brice, Kahn, C. R., Zierath, Juleen R, Vienberg, S. & Barrès, Romain, 2019, In: Hepatology Research. 49, 12, p. 1451-1465

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes

    Isidor, Marie Sophie, Dong, W., Servin-Uribe, R. I., Villarroel, J., Altıntaş, Ali, Ayala-Sumuano, J. T., Varela-Echavarría, A., Barrès, Romain, Stephanopoulos, G., Macotela, Y. & Emanuelli, Brice, 2022, In: International Journal of Obesity. 46, 3, p. 535-543

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Pyruvate kinase M2 represses thermogenic gene expression in brown adipocytes

    Isidor, Marie Sophie, Winther, Sally, Markussen, L. K., Basse, A. L., Quistorff, B., Nedergaard, J., Emanuelli, Brice & Hansen, Jacob B., 2020, In: FEBS Letters. 594, 7, p. 1218-1225

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

    Jing, E., Emanuelli, Brice, Hirschey, M. D., Boucher, J., Lee, K. Y., Lombard, D., Verdin, E. M. & Kahn, C. R., 30 Aug 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. 14608-13 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473

    Khanh-Van Tran, Brown, E. L., DeSouza, T., Jespersen, N. Z., Nandrup-Bus, C., Yang, Q., Yang, Z., Desai, A., Min, S. Y., Rojas-Rodriguez, R., Lundh, M., Feizi, A., Willenbrock, H., Larsen, T. J., Severinsen, M. C. K., Malka, K., Mozzicato, A. M., Deshmukh, A. S., Emanuelli, B., Pedersen, B. K. & 4 others, Fitzgibbons, T., Schéele, Camilla Charlotte Nielsen, Corvera, S. & Nielsen, S., 2020, In: Nature Metabolism. 2, p. 397-412

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Editorial: Healthy adipose tissue expansion

    Lee, K. Y., Emanuelli, Brice & Ussar, S., 2023, In: Frontiers in Cell and Developmental Biology. 11, 3 p., 1287533.

    Research output: Contribution to journal › Editorial › Research

  20. Published

    Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

    Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions

    Lund, J., Breum, A. W., Gil, C., Falk, S., Sass, F., Isidor, M. S., Dmytriyeva, O., Ranea-Robles, P., Mathiesen, C. V., Basse, A. L., Johansen, O. S., Fadahunsi, N., Lund, C., Nicolaisen, T. S., Klein, A. B., Ma, T., Emanuelli, B., Kleinert, M., Sørensen, C. M., Gerhart-Hines, Z. & 1 others, Clemmensen, Christoffer, 2023, In: Nature Metabolism. 5, 4, p. 677-698 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue

    Lundh, M., Petersen, P. S., Isidor, Marie Sophie, Kazoka-Sørensen, D. N., Plucinska, Kaja, Shamsi, F., Ørskov, Cathrine, Tozzi, M., Brown, E. L., Andersen, E., Ma, Tao, Müller, U. A., Barrès, Romain, Kristiansen, V. B., Gerhart-Hines, Zach, Tseng, Y. & Emanuelli, Brice, 2019, In: EMBO Reports. 20, 8, e48216.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

    Lundh, M., Plucinska, Kaja, Isidor, Marie Sophie, Petersen, P. S. S. & Emanuelli, Brice, Oct 2017, In: Molecular Metabolism. 6, 10, p. 1313-1320 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Cold-induction of afadin in brown fat supports its thermogenic capacity

    Lundh, M., Altıntaş, Ali, Tozzi, M., Fabre, O., Ma, Tao, Shamsi, F., Gerhart-Hines, Zach, Barrès, Romain, Tseng, Y. & Emanuelli, Brice, 2021, In: Scientific Reports. 11, 11 p., 9794.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism

    Macotela, Y., Emanuelli, Brice, Bång, A. M., Espinoza, D. O., Boucher, J., Beebe, K., Gall, W. & Kahn, C. R., 2011, In: PLOS ONE. 6, 6, p. e21187

    Research output: Contribution to journal › Journal article › Research › peer-review

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