Central Regulation of Metabolism in the Pers Group
The Pers Group conducts cutting-edge research on the molecular mechanisms underlying obesity and type 2 diabetes susceptibility, particularly focusing on brain-centric molecular pathways influenced by polygenic risk. We integrate advanced machine learning, cutting-edge variant-to-function techniques from human genetics, and CRISPR-based genome engineering to uncover novel insights. To validate our hypotheses, we employ physiologically relevant transgenic rodent models, bridging the gap between molecular discoveries and real-world therapeutic applications.
The overarching aim of the Pers Group is to identify molecular pathways in the brain mediating genetic susceptibility to metabolic disease.
Obesity and type 2 diabetes are a heritable multifactorial disease with incompletely understood etiologies. The Pers group investigates the role of the brain in the control of metabolic fuel homeostasis with a focus on how polygenetic liability in energy and blood glucose-regulatory systems contribute to the pathogenesis of obesity and diabetes. The group leverages computational techniques, human genetics and single-cell sequencing data, pharmacological and physiological studies to explore how rodent and human brain cell populations are involved in the response to an array of humoral signals, including FGF1, GLP-1, leptin, insulin, and nutrients such as glucose.
“A genetic map of the mouse dorsal vagal complex and its role in obesity”
Published in Nature Metabolism in 2021, this article presents a transcriptional and chromatin-accessibility single-cell atlas of the mouse dorsal vagal complex and uses body mass index genome-wide association data and Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools to show that some of them control feeding.
“Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission”
Published in Nature Communications in 2020, this article uses single-cell RNA sequencing and histological techniques to show that sustained diabetes remission induced by intracerebroventricular fibroblast growth factor 1 is dependent on intact melanocortin receptor 4 signaling.
"Genetic mapping of etiologic brain cell types for obesity"
Published in eLife in 2020 this study integrates published single-cell RNA-sequencing data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index genome-wide association study data to pinpoint brain cell populations likely mediating polygenetic for obesity.
|Aalling, Nadia Nielsen||Postdoc||+4535330289|
|Andersen, Charlotte Høy||Academic Research Staff|
|Belmont-Rausch, Dylan Matthew||Postdoc||+4535326151|
|Borgmann, Diba||Guest Researcher|
|Brown, Jenny Marie||Postdoc||+4535334806|
|Christensen, Oliver Pugerup||Master Student|
|Egerod, Kristoffer Lihme||Research Consultant||+4535337057|
|Fan, Yong||Assistant Professor||+4593509187|
|Lilja-Fischer, Helle Kinggaard||Laboratory Technician||+4526719296|
|Lyu, Liwei||Visiting PhD Student||+4593509186|
|Mathiesen, Cecilie Vad||Guest Researcher|
|Mottelson, Noah Wulff||PhD Fellow|
|Pers, Tune H||Associate Professor - Promotion Programme||+4535335755|
|Stannius, Tobias Overlund||Guest Researcher|
|Thomas, Cecilia Engel||Postdoc|
|van Hilten, Arno||Research Assistant||+4535321319|