Central Regulation of Metabolism in the Pers Group

The Pers Group's research focuses on the identification of central nervous system mechanisms through which genetic variants mediate susceptibility to obesity and type 2 diabetes. To that end, we leverage advanced model systems, machine learning, and CRISPR-based variant-to-function techniques. We employ physiologically relevant transgenic rodent models to validate our hypotheses and to bridge the gap between molecular discoveries and real-world therapeutic applications.

Group photo of the Pers Group
Top row (left to right): Jenny Brown, Arno van Hilten, Shad Hassan, Diba Borgmann, Cecilia Engel Thomas, Kristoffer Egerod
Bottom row (left to right): Bernd Coester, Helle Kinggaard Lilja-Fischer, Oliver Pugerup Christensen, Dylan Rausch, Tune H. Pers

 

 

 

The overarching aim of the Pers Group is to identify molecular pathways in the brain mediating genetic susceptibility to metabolic disease.

Obesity and type 2 diabetes are a heritable multifactorial disease with incompletely understood etiologies. The Pers group investigates the role of the brain in the control of metabolic fuel homeostasis with a focus on how polygenetic liability in energy and blood glucose-regulatory systems contribute to the pathogenesis of obesity and diabetes. The group leverages computational techniques, human genetics and single-cell sequencing data, pharmacological and physiological studies to explore how rodent and human brain cell populations are involved in the response to an array of humoral signals, including FGF1, GLP-1, leptin, insulin, and nutrients such as glucose.

 

 

 

 

 

 

“A genetic map of the mouse dorsal vagal complex and its role in obesity”
Published in Nature Metabolism in 2021, this article presents a transcriptional and chromatin-accessibility single-cell atlas of the mouse dorsal vagal complex and uses body mass index genome-wide association data and Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-based chemogenetic tools to show that some of them control feeding.

“Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission”

Published in Nature Communications in 2020, this article uses single-cell RNA sequencing and histological techniques to show that sustained diabetes remission induced by intracerebroventricular fibroblast growth factor 1 is dependent on intact melanocortin receptor 4 signaling.

"Genetic mapping of etiologic brain cell types for obesity"
Published in eLife in 2020 this study integrates published single-cell RNA-sequencing data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index  genome-wide association study data to pinpoint brain cell populations likely mediating polygenetic for obesity. 

 

 

Funding - Principal Investigator on external grants

  • 2019 – 2022 PI: Danish Research Council for Independent Research Sapere Aude Starting Grant: ‘Hypothalamic plasticity in obesity’ (EUR 781,350)
  • 2016 – 2018 PI: Novo Nordisk Foundation research grant for basic and clinical research in endocrinology and experimental physiology: ‘Identification and characterization of GLP-1 responding hypothalamic cell types’ (EUR 187,500)
  • 2015 – 2020 PI: Lundbeck Foundation Fellowship: ‘Understanding weight gain by uncovering shared biology between schizophrenia and obesity’ (EUR 1,339,700)
  • 2013 – 2015 PI: Benzon Foundation Postdoc Fellowship: ‘Systems genetics in obesity: Integration of association data from 350,000 individuals with cell type-specific hypothalamic expression data’ (EUR 93,750)
  • 2011 – 2013 PI: Danish Research Council for Independent Research | Medical Sciences postdoc fellowship: ‘Systems genetics in obesity: Common and rare variant data analysis for identification of risk variants and susceptibility pathways’ (EUR 364,067).

Honors and awards

  • 2019 Danish Diabetes Academy Young Investigator Award.
  • 2017 Jakobiner Society honorary medal for young researchers below 40 years.
  • 2016present   Member of the Young Academy of the Royal Danish Academy of Sciences and Letters.
  • 2011 The Danish Council for Independent Research Sapere Aude award for 'the best young researchers at Postdoc level'.

Current management Activities

  • Part of the CBMR center leadership team.
  • Steering group member of the University of Copenhagen Center for Health Data Science.
  • Advisory board of the Single-Cell Omics Platform at CBMR.

International Collaborations:
Tune H. Pers is principal investigator at the Novo Nordisk Foundation Center for Genomic Mechanisms in Disease, and he is a part of the Genetic Investigation of ANthropometric Traits (GIANT) and the International Common Disease Alliance (ICDA) consortia. In addition, he closely collaborates with principal investigators at the University of Washington (Seattle, USA), the University of Michigan (Ann Arbor, USA) and Oxford University (Oxford, UK).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Group Leader

Tune H. Pers
Associate Professor

Phone: +45 3533 5755
tune.pers@sund.ku.dk

Twitter:
Tune H. Pers (@tunepers)

Tune H. Pers

Staff list

Name Title Phone E-mail
Belmont-Rausch, Dylan Matthew Postdoc +4535326151 E-mail
Borgmann, Diba Postdoc   E-mail
Brown, Jenny Marie Postdoc +4535334806 E-mail
Christensen, Oliver Pugerup Master Student   E-mail
Coester, Bernd Postdoc +4535328008 E-mail
Egerod, Kristoffer Lihme Research Consultant +4535337057 E-mail
Fan, Yong Assistant Professor +4593509187 E-mail
Hassan, Shad Academic Research Officer +4535323938 E-mail
Laurentiussen, Claes Ottzen Master Student   E-mail
Lilja-Fischer, Helle Kinggaard Laboratory Technician +4526719296 E-mail
Lyu, Liwei Visiting PhD Student +4593509186 E-mail
Mottelson, Noah Wulff PhD Fellow   E-mail
Pers, Tune H Associate Professor - Promotion Programme +4535335755 E-mail
Stannius, Tobias Overlund Guest Researcher   E-mail
Thomas, Cecilia Engel Postdoc   E-mail
van Hilten, Arno Postdoc +4535321319 E-mail