Metabolomics Research in the Moritz Group
Our goal is to use metabolomics approaches to study the role of metabolites and lipids in metabolism. By using mass spectrometry based methods we can screen for 100s to 1000s compounds or target specific compounds in different biological systems. We hope to be able to uncover the basic role of metabolites in metabolism and their role in developing diseases.
Understanding basic metabolism is necessary for understanding how metabolic diseases are developed, and thereby being able to develop effective diagnostics and treatments.
Moritz group uses metabolomics approaches to understand the role of the metabolome in controlling different aspects of metabolism in humans. We are studying the metabolome and fluxomes in different cell types as well performing large scale analysis on human plasma cohorts. An important part of the research is to develop methodology for analyzing the metabolome. The method development covers strategies for sample preparation, mass spectrometry analysis and data processing.
"The human batokine EPDR1 regulates β-cell metabolism and function"
Published in Molecular Metabolism 2022, suggesting that to maintain glucose homeostasis in obese people, upregulation of EPDR1 may improve β-cell function via channeling glycolysis-derived pyruvate to the mitochondrial TCA cycle.
"Integration of molecular profiles in a longitudinal wellness profiling cohort"
Published in Nature Communication 2020, we show by profiling a longitudinal wellness cohort with high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low, supporting an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
"Functional metabolomics as a tool to analyze mediator function and structure in plants"
Published in PlosOne 2017, showing that metabolomics can be used for prediction of biochemical function. With metabolomics and appropriate data analysis tools, we could predict where in the Mediator complex the different subunits are located.