Niels Grarup
Associate Professor
Hansen Group
Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.
- 2022
- Published
14-fold increased prevalence of rare glucokinase gene variant carriers in unselected Danish patients with newly diagnosed type 2 diabetes
Gjesing, A. P., Engelbrechtsen, L., Cathrine B. Thuesen, A., Have, C. T., Hollensted, M., Grarup, N., Linneberg, A., Steen Nielsen, J., Christensen, L. B., Thomsen, R. W., Johansson, K. E., Cagiada, M., Gersing, S., Hartmann-Petersen, R., Lindorff-Larsen, K., Vaag, A., Sørensen, H. T., Brandslund, I., Beck-Nielsen, H., Pedersen, O. & 2 others, , 2022, In: Diabetes Research and Clinical Practice. 194, 9 p., 110159.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas, S., Judd, J., Graham, S. E., Kanoni, S., Wang, Y., Surakka, I., Wenz, B., Clarke, S. L., Chesi, A., Wells, A., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D. & 32 others, , 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A saturated map of common genetic variants associated with human height
Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S-H., Ferreira, T., Highland, H. H., Ji, Y. & 37 others, , 2022, In: Nature. 610, p. 704–712Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention
Jørsboe, E., Andersen, M. K., Skotte, L., Stæger, F. F., Færgeman, N. J., Hanghøj, K., Santander, C. G., Senftleber, N. K., Diaz, L. J., Overvad, M., Waples, R. K., Geller, F., Bjerregaard, P., Melbye, M., Larsen, C. V. L., Feenstra, B., Anders Koch, K., Jørgensen, M. E., Grarup, N., Moltke, I. & 2 others, , 2022, In: Human Genetics and Genomics Advances. 3, 4, 10 p., 100118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An adult-based genetic risk score for hepatic fat associates with liver and lipid traits in Danish children and adolescents
Huang, Yun, Stinson, Sara, Juel, H. B., Lund, Morten Asp Vonsild, Holm, L. A., Fonvig, Cilius Esmann, Grarup, Niels, Pedersen, Oluf Borbye, Christiansen, Michael, Krag, A., Stender, S., Holm, Jens-Christian & Hansen, Torben, 2022, In: Journal of Hepatology. 77, p. S450-S450 1 p., FRI104.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Association of general health and lifestyle factors with the salivary microbiota – Lessons learned from the ADDITION-PRO cohort
Poulsen, C. S., Nygaard, Nikoline, Constancias, F., Stankevic, Evelina, Kern, T., Witte, D. R., Vistisen, D., Grarup, Niels, Pedersen, Oluf Borbye, Midjord-Belstrøm, Daniel & Hansen, Torben, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 15 p., 1055117.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of milk intake with hay fever, asthma, and lung function: a Mendelian randomization analysis
Skaaby, T., Kilpeläinen, Tuomas O., Mahendran, Y., Huang, L. O., Sallis, H., Thuesen, B. H., Kårhus, L. L., Leth-Møller, K. B., Grarup, Niels, Hansen, Torben, Pedersen, Oluf Borbye, Burgess, S., Munafò, M. R. & Linneberg, Allan René, 2022, In: European Journal of Epidemiology. 37, p. 713-722Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study
Durda, P., Raffield, L. M., Lange, E. M., Olson, N. C., Jenny, N. S., Cushman, M., Deichgraeber, P., Grarup, Niels, Jonsson, Anna Elisabet, Hansen, Torben, Mychaleckyj, J. C., Psaty, B. M., Reiner, A. P., Tracy, R. P. & Lange, L. A., 2022, In: Journal of the American Heart Association. 11, 21, 14 p., e024374.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DeepFake electrocardiograms: the key for open science for artificial intelligence in medicine
Thambawita, V., Isaksen, Jonas L., Hicks, S. A., Ghouse, Jonas, Ahlberg, Gustav, Linneberg, Allan René, Grarup, Niels, Ellervik, Christina, Olesen, Morten Steen Salling, Hansen, Torben, Graff, C., Holstein-Rathlou, N., Strümke, I., Hammer, H. L., Maleckar, M., Halvorsen, P., Riegler, M. A. & Kanters, Jørgen K., 2022, 17 p. (medRxiv).Research output: Working paper › Preprint › Research
- Published
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J-W., Haessler, J., Lyytikäinen, L-P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S. & 31 others, , 2022, In: Nature Communications. 13, 1, 18 p., 5144.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
Vogelezang, S., Bradfield, J. P., Early Growth Genetics Consortium, Ahluwalia, T. V. S., Liu, X., Schnurr, T. M., Frithioff-Bøjsøe, C., Bønnelykke, K., Lind, M. V., Lauritzen, L., Michaelsen, K. F., Lund, M. A. V., Melbye, M., Morgen, C. S., Pedersen, O. B., Holm, J-C., Grarup, N., Hansen, T., Nohr, E. A., Bisgaard, H. & 3 others, , 2022, In: BMC Medical Genomics. 15, 16 p., 124.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang, Z., Emmerich, A., Pillon, N. J., Moore, T., Hemerich, D., Cornelis, M. C., Mazzaferro, E., Broos, S., Ahluwalia, T. S., Bartz, T. M., Bentley, A. R., Bielak, L. F., Chong, M., Chu, A. Y., Berry, D., Dorajoo, R., Dueker, N. D., Kasbohm, E., Feenstra, B., Feitosa, M. F. & 32 others, , 2022, In: Nature Genetics. 54, p. 1332–1344 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB
Eliasen, A. U., Pedersen, C. E. T., Rasmussen, M. A., Wang, N., Soverini, M., Fritz, A., Stokholm, J., Chawes, B. L., Morin, A., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Mortensen, P. B., Hougaard, D. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O., Nordentoft, M. & 14 others, , 2022, In: Journal of Allergy and Clinical Immunology. 150, 3, p. 622-630Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C. & 519 others, , 2022, In: Genome Biology. 23, 1, 42 p., 268.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of sucrase-isomaltase function increases acetate levels and improves metabolic health in Greenlandic cohorts
Andersen, M. K., Skotte, L., Jørsboe, E., Polito, R., Stæger, F. F., Aldiss, P., Hanghøj, K., Waples, R. K., Santander, C. G., Grarup, N., Dahl-Petersen, I. K., Diaz, L. J., Overvad, M., Senftleber, N. K., Søborg, B., Larsen, C. V. L., Lemoine, C., Pedersen, O., Feenstra, B., Bjerregaard, P. & 9 others, , 2022, In: Gastroenterology. 162, 4, p. 1171-1182.e3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mendelian randomization suggests a causal effect of abdominal obesity on postprandial lipemia
Christiansen, Malene Revsbech, Hansen, Torben, Sørensen, Thorkild I.A., Grarup, Niels, García Ureña, Mario, Borisevich, D., Oppert, J., Martinez Hernandez, J. A., Blaak, E. & Kilpeläinen, Tuomas O., 2022, In: European Journal of Human Genetics. 30, Supplement 1, p. 184 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., Horikoshi, M., Mercader, J. M., Taliun, D., Moon, S., Kwak, S-H., Robertson, N. R., Rayner, N. W., Loh, M., Kim, B-J., Chiou, J. & 31 others, , 2022, In: Nature Genetics. 54, 5, p. 560-572 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare coding variants in 35 genes associate with circulating lipid levels - A multi-ancestry analysis of 170,000 exomes
Hindy, G., Dornbos, P., Chaffin, M. D., Liu, D. J., Wang, M., Selvaraj, M. S., Zhang, D., Park, J., Aguilar-Salinas, C. A., Antonacci-Fulton, L., Ardissino, D., Arnett, D. K., Aslibekyan, S., Atzmon, G., Ballantyne, C. M., Barajas-Olmos, F., Barzilai, N., Becker, L. C., Bielak, L. F., Bis, J. C. & 33 others, , 2022, In: American Journal of Human Genetics. 109, 1, p. 81-96 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes
O'Connor, M. J., Schroeder, P., Huerta-Chagoya, A., Cortés-Sánchez, P., Bonàs-Guarch, S., Guindo Martínez, Marta, Cole, J. B., Kaur, V., Torrents, D., Veerapen, K., Grarup, Niels, Kurki, M., Friis, Carsten, Pedersen, Oluf Borbye, Brandslund, I., Linneberg, Allan René, Hansen, Torben, Leong, A., Florez, J. C. & Mercader, J. M., 2022, In: Diabetes. 71, 3, p. 554–565Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism
Metz, Sophia, Krarup, N. T., Bryrup, T., Støy, J., Andersson, E. A., Christoffersen, Christina, Neville, M. J., Christiansen, Malene Revsbech, Jonsson, Anna Elisabet, Witte, D. R., Kampmann, U., Nielsen, L. B., Jørgensen, Niklas Rye, Karpe, F., Grarup, Niels, Pedersen, Oluf Borbye, Kilpeläinen, Tuomas O. & Hansen, Torben, 2022, In: Journal of the Endocrine Society. 6, 5, 10 p., bvac034.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 10892605
Most downloads
-
5494
downloads
Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
5246
downloads
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
2450
downloads
Estimation of allele frequency and association mapping using next-generation sequencing data
Research output: Contribution to journal › Journal article › Research › peer-review
Published