Functional Proteomics in Metabolism in the Deshmukh Group
Our goal is to investigate protein dynamics and how they relate to metabolism. By using Mass-Spectrometry-based proteomics, we provide detailed understanding of the molecular mechanisms that regulate whole-body metabolism. We uncover new insights into metabolic disease, and strategies for their prevention and treatment.
The development of metabolic diseases are highly complex and likely to be the result of altered protein dynamics.
The Deshmukh Group combines state-of-the art proteomics technology with in vivo and in vitro expertise, to address how altered protein dynamics influence metabolism during health and disease. We are specifically interested in how exercise and diet influence the secretome, post-translational modifications, subcellular organization of proteins and the mitochondrial supercomplexome.
Associate Professor Atul Deshmukh explains; “Our new approach of combining proteomics within metabolic studies provides previously unobtainable mechanistic insight into the development and treatment of metabolic diseases.
- Mass-spectrometry Based Proteomics Reveals Mitochondrial Supercomplexome Plasticity
Published in Cell Reports in 2021, this study provides deep insights into mitochondrial supercomplexome plasticity in skeletal muscle from sedentary and exercise-trained mice. This study illuminates previously undetectable complexity in mitochondrial plasticity. - Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
Published in Nature Communications in 2021, this study provides deep insight into human slow and fast muscle fiber proteome in response to exercise training. This study reveals previously unknown markers for exercised induced adaptations in slow and fast muscle fibers. - Proteomics-Based Comparative Mapping of the Secretome of Human Brown and White Adipocyte Reveals EPDR1 as a Novel Batokine
Published in Cell Metabolism in 2019, this study was among the first to map the secretomes of human brown and white adipocytes. The study identifies several novel batokines, including EPDR1, which is necessary for brown fat differentiation.
Our group works in close collaborations with Professor Juleen Zierath’s Group at CBMR and Professor Matthias Mann’s Clinical Proteomics Group at Novo Nordisk Foundation Center for Protein Research.
Additionally, the group works alongside numerous national and international collaborators.
Funding: Associate Professor Atul Deshmukh has recently been awarded a Future Leaders Award from European Foundation of the Study of Diabetes/Novo Nordisk Foundation. This award funds research over the next five years.
Group members
| Name | Title | Job responsibilities | Phone | |
|---|---|---|---|---|
| Cervone, Daniel Thomas | Postdoc | Zierath Group, Circadian Biology, Deshmukh Group, Functional Proteomics in Metabolism | +4535320581 | |
| Deshmukh, Atul Shahaji | Associate Professor | Group Leader, Deshmukh Group, Functional Proteomics in Metabolism | +4535325313 | |
| Gonzalez-Franquesa, Alba | Postdoc | Deshmukh Group, Functional Proteomics in Metabolism | +4535337618 | |
| Moreno Justicia, Roger | Academic Staff | Deshmukh Group, Functional Proteomics in Metabolism | +4535334182 | |
| Peijs, Lone | Postdoc | Deshmukh Group, Functional Proteomics in Metabolism | ||
| Samodova, Diana | Postdoc | Deshmukh Group, Functional Proteomics in Metabolism | ||
| Stocks, Ben Nicholas | Postdoc | Deshmukh Group, Functional Proteomics in Metabolism | +4535332944 |
From the left: Alba Gonzalez-Franquesa, Roger Moreno Justicia, Jeppe Kjærgaard Larsen, Lone Peijs, Ben Nicholas Stocks and Atul Shahaji Deshmukh.