Functional Proteomics in Metabolism in the Deshmukh Group
Our goal is to investigate protein dynamics and how they relate to metabolism. By using Mass-Spectrometry-based proteomics, we provide detailed understanding of the molecular mechanisms that regulate whole-body metabolism. We uncover new insights into metabolic disease, and strategies for their prevention and treatment.
The development of metabolic diseases are highly complex and likely to be the result of altered protein dynamics.
The Deshmukh Group combines state-of-the art proteomics technology with in vivo and in vitro expertise, to address how altered protein dynamics influence metabolism during health and disease. We are specifically interested in how exercise and diet influence the secretome, post-translational modifications, subcellular organization of proteins and the mitochondrial supercomplexome.
Associate Professor Atul Deshmukh explains; “Our new approach of combining proteomics within metabolic studies provides previously unobtainable mechanistic insight into the development and treatment of metabolic diseases.
- Mass-spectrometry Based Proteomics Reveals Mitochondrial Supercomplexome Plasticity
Published as a preprint in BioRxiv in 2019, this study provides deep insights into mitochondrial supercomplexome plasticity in skeletal muscle from sedentary and exercise-trained mice. This study illuminates previously undetectable complexity in mitochondrial plasticity. - Proteomics-Based Comparative Mapping of the Secretome of Human Brown and White Adipocyte Reveals EPDR1 as a Novel Batokine
Published in Cell Metabolism in 2019, this study was among the first to map the secretomes of human brown and white adipocytes. The study identifies several novel batokines, including EPDR1, which is necessary for brown fat differentiation. - Proteomics Analysis of Skeletal Muscle From Leptin-Deficient Ob/Ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition
Published in Proteomics in 2018, this study shows that the enzymes involved in lipid metabolism in skeletal muscle from obese and insulin resistant mice were increased, providing evidence against reduced fatty acid oxidation in lipid-induced insulin resistance.
Our group works in close collaborations with Professor Juleen Zierath’s Group at CBMR and Professor Matthias Mann’s Clinical Proteomics Group at Novo Nordisk Foundation Center for Protein Research.
Additionally, the group works alongside numerous national and international collaborators.
Funding: Associate Professor Atul Deshmukh has recently been awarded a Future Leaders Award from European Foundation of the Study of Diabetes/Novo Nordisk Foundation. This award funds research over the next five years.
Group members
| Name | Title | Phone | |
|---|---|---|---|
| Deshmukh, Atul Shahaji | Associate professor | +45 353-25313 | |
| Gonzalez-Franquesa, Alba | Postdoc | +45 353-37618 | |
| Larsen, Jeppe Kjærgaard | Research assistant | ||
| Moreno Justicia, Roger | Academic staff, FU | +45 353-34182 | |
| Peijs, Lone | Postdoc | ||
| Stocks, Ben Nicholas | Postdoc | +45 353-32944 |
