Endocrine Regulation of Metabolism in the Juul Holst Group

The overarching aim of the Juul Holst Group is to understand the functional challenges of obesity and diabetes, and to provide new principles for improved therapy of these conditions.

See also the Translational Metabolic Physiology Group of the Department of Biomedical Sciences.

Main findings

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ.
Mol Metab. 2018 May;11:84-95. doi: 10.1016/j.molmet.2018.03.007. Epub 2018 Mar 17

Discovery, characterization, and clinical development of the glucagon-like peptides.
Drucker DJ, Habener JF, Holst JJ.
J Clin Invest. 2017 Dec 1;127(12):4217-4227. doi: 10.1172/JCI97233. Epub 2017 Dec 1. Review.

Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.
Wewer Albrechtsen NJ, Kuhre RE, Hornburg D, Jensen CZ, Hornum M, Dirksen C, Svane M, Gasbjerg LS, Jørgensen NB, Gabe MN, Balk-Møller E, Albrechtsen R, Winther-Sørensen M, Galsgaard KD, Meissner F, Jorsal T, Lund A, Vilsbøll T, Eliasen R, Bojsen-Møller KN, Idorn T, Deacon CF, Knop FK, Rosenkilde MM, Hartmann B, Feldt-Rasmussen B, Mann M, Madsbad S, Holst JJ.
Cell Rep. 2017 Nov 7;21(6):1452-1460. doi: 10.1016/j.celrep.2017.10.034

Staff of the Juul Holst Group

Group leader: Professor Jens Juul Holst