Cancer and Pain
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Cancer and Pain. / Hansen, Rie Bager; Falk, Sarah.
The Oxford Handbook of the Neurobiology of Pain. Oxford University Press, 2018.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Cancer and Pain
AU - Hansen, Rie Bager
AU - Falk, Sarah
PY - 2018/11
Y1 - 2018/11
N2 - Pain is a common and feared complication for many cancer patients. Cancer pain covers numerous pain syndromes; since the treatment is complex, it is essential to assess each individual patient with cancer pain thoroughly. Cancer pain includes not only elements of inflammatory and neuropathic pain, but also, importantly, cancer-specific elements. Starting with the clinical aspects of cancer pain and the current knowledge from in vivo models, this chapter provides an overview of the neurobiology known to drive cancer-induced bone pain as it evolves through the complex interplay between primary afferents, tumor cells, and bone cells. There continue to be many uncertainties and unknown mechanisms involved in cancer pain, and an effort to discover novel therapeutic targets should be emphasized as cancer pain poses an increasing clinical and socioeconomic burden.
AB - Pain is a common and feared complication for many cancer patients. Cancer pain covers numerous pain syndromes; since the treatment is complex, it is essential to assess each individual patient with cancer pain thoroughly. Cancer pain includes not only elements of inflammatory and neuropathic pain, but also, importantly, cancer-specific elements. Starting with the clinical aspects of cancer pain and the current knowledge from in vivo models, this chapter provides an overview of the neurobiology known to drive cancer-induced bone pain as it evolves through the complex interplay between primary afferents, tumor cells, and bone cells. There continue to be many uncertainties and unknown mechanisms involved in cancer pain, and an effort to discover novel therapeutic targets should be emphasized as cancer pain poses an increasing clinical and socioeconomic burden.
U2 - 10.1093/oxfordhb/9780190860509.013.32
DO - 10.1093/oxfordhb/9780190860509.013.32
M3 - Book chapter
BT - The Oxford Handbook of the Neurobiology of Pain
PB - Oxford University Press
ER -
ID: 208723961