Neurons in the preBötzinger complex and VRG are located in proximity to arterioles in newborn mice

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Neurons in the preBötzinger complex and VRG are located in proximity to arterioles in newborn mice. / Falk, Sarah; Rekling, Jens C.

In: Neuroscience Letters, 2008.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Falk, S & Rekling, JC 2008, 'Neurons in the preBötzinger complex and VRG are located in proximity to arterioles in newborn mice', Neuroscience Letters. https://doi.org/10.1016/j.neulet.2008.11.042

APA

Falk, S., & Rekling, J. C. (2008). Neurons in the preBötzinger complex and VRG are located in proximity to arterioles in newborn mice. Neuroscience Letters. https://doi.org/10.1016/j.neulet.2008.11.042

Vancouver

Falk S, Rekling JC. Neurons in the preBötzinger complex and VRG are located in proximity to arterioles in newborn mice. Neuroscience Letters. 2008. https://doi.org/10.1016/j.neulet.2008.11.042

Author

Falk, Sarah ; Rekling, Jens C. / Neurons in the preBötzinger complex and VRG are located in proximity to arterioles in newborn mice. In: Neuroscience Letters. 2008.

Bibtex

@article{8792b0a0cde711dd9473000ea68e967b,
title = "Neurons in the preB{\"o}tzinger complex and VRG are located in proximity to arterioles in newborn mice",
abstract = "The constant cyclic respiratory activity in the brainstem requires an un-interrupted blood flow providing glucose and O(2) to neurons generating respiratory rhythm. Here we used a combination of classical vascular visualization techniques, and calcium imaging, to compare the microvascular structure and localization of active respiratory neurons in the brainstem of newborn mice at the level of the preB{\"o}tzinger complex (PBC) and ventral respiratory group. The brainstem is supplied with perforating arteries, which enter primarily in the midline and in a circumscribed region mid-laterally in the medulla. Presumed arterioles then pass dorso-medially with a high density immediately lateral to the midline, and mid-laterally at approximately 60% of the midline-to-lateral edge distance. Calcium imaging, using Fluo-8, AM, showed that active PBC/VRG neurons are located in the same region where a high density of arterioles is found. We conclude that the striking co-localization of medullary arterioles and the PBC/VRG could imply that respiratory neurons may derive part of their glucose and oxygen consumption directly from arterioles, and that humoral factors affecting ventilation may reach respiratory neurons by precapillary transport mechanisms.",
author = "Sarah Falk and Rekling, {Jens C}",
year = "2008",
doi = "10.1016/j.neulet.2008.11.042",
language = "English",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Neurons in the preBötzinger complex and VRG are located in proximity to arterioles in newborn mice

AU - Falk, Sarah

AU - Rekling, Jens C

PY - 2008

Y1 - 2008

N2 - The constant cyclic respiratory activity in the brainstem requires an un-interrupted blood flow providing glucose and O(2) to neurons generating respiratory rhythm. Here we used a combination of classical vascular visualization techniques, and calcium imaging, to compare the microvascular structure and localization of active respiratory neurons in the brainstem of newborn mice at the level of the preBötzinger complex (PBC) and ventral respiratory group. The brainstem is supplied with perforating arteries, which enter primarily in the midline and in a circumscribed region mid-laterally in the medulla. Presumed arterioles then pass dorso-medially with a high density immediately lateral to the midline, and mid-laterally at approximately 60% of the midline-to-lateral edge distance. Calcium imaging, using Fluo-8, AM, showed that active PBC/VRG neurons are located in the same region where a high density of arterioles is found. We conclude that the striking co-localization of medullary arterioles and the PBC/VRG could imply that respiratory neurons may derive part of their glucose and oxygen consumption directly from arterioles, and that humoral factors affecting ventilation may reach respiratory neurons by precapillary transport mechanisms.

AB - The constant cyclic respiratory activity in the brainstem requires an un-interrupted blood flow providing glucose and O(2) to neurons generating respiratory rhythm. Here we used a combination of classical vascular visualization techniques, and calcium imaging, to compare the microvascular structure and localization of active respiratory neurons in the brainstem of newborn mice at the level of the preBötzinger complex (PBC) and ventral respiratory group. The brainstem is supplied with perforating arteries, which enter primarily in the midline and in a circumscribed region mid-laterally in the medulla. Presumed arterioles then pass dorso-medially with a high density immediately lateral to the midline, and mid-laterally at approximately 60% of the midline-to-lateral edge distance. Calcium imaging, using Fluo-8, AM, showed that active PBC/VRG neurons are located in the same region where a high density of arterioles is found. We conclude that the striking co-localization of medullary arterioles and the PBC/VRG could imply that respiratory neurons may derive part of their glucose and oxygen consumption directly from arterioles, and that humoral factors affecting ventilation may reach respiratory neurons by precapillary transport mechanisms.

U2 - 10.1016/j.neulet.2008.11.042

DO - 10.1016/j.neulet.2008.11.042

M3 - Journal article

C2 - 19041367

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

ER -

ID: 9255651