Renaissance of leptin for obesity therapy
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Renaissance of leptin for obesity therapy. / Quarta, Carmelo; Sánchez-Garrido, Miguel A; Tschöp, Matthias H; Clemmensen, Christoffer.
In: Diabetologia, Vol. 59, No. 5, 05.2016, p. 920-7.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Renaissance of leptin for obesity therapy
AU - Quarta, Carmelo
AU - Sánchez-Garrido, Miguel A
AU - Tschöp, Matthias H
AU - Clemmensen, Christoffer
PY - 2016/5
Y1 - 2016/5
N2 - Diet-induced obesity and its metabolic comorbidities constitute an overwhelming health crisis and there is an urgent need for safe and effective pharmacological interventions. Being largely shelved for decades, scientists are now revisiting the anti-obesity virtues of leptin. Whereas it remains evident that leptin as a stand-alone therapy is not an effective approach, the potential for employing sensitising pharmacology to unleash the weight-lowering properties of leptin has injected new hope into the field. Fascinatingly, these leptin-sensitising agents seem to act via distinct metabolic pathways and may thus, in parallel with their clinical development, serve as important research tools to progress our understanding of the molecular, physiological and behavioural pathways underlying energy homeostasis and obesity pathophysiology. This review summarises a presentation given at the 'Is leptin coming back?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Thomas Meek and Gregory Morton, DOI: 10.1007/s00125-016-3898-3 , and by Gerald Shulman and colleagues, DOI: 10.1007/s00125-016-3909-4 ) and an overview by the Session Chair, Ulf Smith (DOI: 10.1007/s00125-016-3894-7 ).
AB - Diet-induced obesity and its metabolic comorbidities constitute an overwhelming health crisis and there is an urgent need for safe and effective pharmacological interventions. Being largely shelved for decades, scientists are now revisiting the anti-obesity virtues of leptin. Whereas it remains evident that leptin as a stand-alone therapy is not an effective approach, the potential for employing sensitising pharmacology to unleash the weight-lowering properties of leptin has injected new hope into the field. Fascinatingly, these leptin-sensitising agents seem to act via distinct metabolic pathways and may thus, in parallel with their clinical development, serve as important research tools to progress our understanding of the molecular, physiological and behavioural pathways underlying energy homeostasis and obesity pathophysiology. This review summarises a presentation given at the 'Is leptin coming back?' symposium at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Thomas Meek and Gregory Morton, DOI: 10.1007/s00125-016-3898-3 , and by Gerald Shulman and colleagues, DOI: 10.1007/s00125-016-3909-4 ) and an overview by the Session Chair, Ulf Smith (DOI: 10.1007/s00125-016-3894-7 ).
KW - Animals
KW - Body Weight
KW - Energy Metabolism
KW - Homeostasis
KW - Humans
KW - Leptin
KW - Obesity
KW - Signal Transduction
KW - Journal Article
KW - Review
U2 - 10.1007/s00125-016-3906-7
DO - 10.1007/s00125-016-3906-7
M3 - Review
C2 - 26983921
VL - 59
SP - 920
EP - 927
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 5
ER -
ID: 186640162