Changes in nut consumption and subsequent cardiovascular disease risk among us men and women: 3 large prospective cohort studies
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Changes in nut consumption and subsequent cardiovascular disease risk among us men and women : 3 large prospective cohort studies. / Liu, Xiaoran; Guasch-Ferré, Marta; Drouin-Chartier, Jean Philippe; Tobias, Deirdre K.; Bhupathiraju, Shilpa N.; Rexrode, Kathryn M.; Willett, Walter C.; Sun, Qi; Li, Yanping.
In: Journal of the American Heart Association, Vol. 9, No. 7, e013877, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in nut consumption and subsequent cardiovascular disease risk among us men and women
T2 - 3 large prospective cohort studies
AU - Liu, Xiaoran
AU - Guasch-Ferré, Marta
AU - Drouin-Chartier, Jean Philippe
AU - Tobias, Deirdre K.
AU - Bhupathiraju, Shilpa N.
AU - Rexrode, Kathryn M.
AU - Willett, Walter C.
AU - Sun, Qi
AU - Li, Yanping
N1 - Publisher Copyright: © 2020 The Authors.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: We aim to evaluate the association of within-individual changes in consumption of total and specific types of nuts and the subsequent risk of incident cardiovascular disease (CVD) in US men and women. METHODS AND RESULTS: We included 34 103 men from the HPFS (Health Professionals Follow-Up Study) (1986–2012), 77 815 women from the NHS (Nurses’ Health Study) (1986–2012), and 80 737 women from the NHS II (1991–2013). We assessed nut consumption every 4 years using validated food frequency questionnaires. We used multivariable Cox proportional hazards regression models to examine the association between 4-year changes in nut consumption and risk of confirmed CVD end points in the subsequent 4 years. Per 0.5 serving/day increase in total nut consumption was associated with lower risk of CVD (relative risk [RR], 0.92; 95% CI, 0.86–0.98), coronary heart disease (RR, 0.94; 95% CI, 0.89–0.99), and stroke (RR, 0.89; 95% CI, 0.83–0.95). Compared with individuals who remained nonconsumers in a 4-year interval, those who had higher consumption of total nuts (≥0.5 servings/day) had a lower risk of CVD (RR, 0.75; 95% CI, 0.67–0.84), coronary heart disease (RR, 0.80; 95% CI, 0.69–0.93), and stroke (RR, 0.68; 95% CI, 0.57–0.82) in next 4 years. Individuals who decreased nut consumption by ≥0.50 servings/day had a higher risk of developing CVD (RR, 1.14; 95% CI, 0.99–1.32), coronary heart disease (RR, 1.06; 95% CI, 0.88–1.28), and stroke (RR, 1.28; 95% CI, 1.02–1.60) when compared with those who maintained their nut consumption. CONCLUSIONS: Increasing total consumption of nuts and intake of individual types of nuts (eg, walnuts, other tree nuts, and peanuts) was associated with a subsequent lower risk of CVD. These data support the role of nut intake in the primary prevention of CVD.
AB - BACKGROUND: We aim to evaluate the association of within-individual changes in consumption of total and specific types of nuts and the subsequent risk of incident cardiovascular disease (CVD) in US men and women. METHODS AND RESULTS: We included 34 103 men from the HPFS (Health Professionals Follow-Up Study) (1986–2012), 77 815 women from the NHS (Nurses’ Health Study) (1986–2012), and 80 737 women from the NHS II (1991–2013). We assessed nut consumption every 4 years using validated food frequency questionnaires. We used multivariable Cox proportional hazards regression models to examine the association between 4-year changes in nut consumption and risk of confirmed CVD end points in the subsequent 4 years. Per 0.5 serving/day increase in total nut consumption was associated with lower risk of CVD (relative risk [RR], 0.92; 95% CI, 0.86–0.98), coronary heart disease (RR, 0.94; 95% CI, 0.89–0.99), and stroke (RR, 0.89; 95% CI, 0.83–0.95). Compared with individuals who remained nonconsumers in a 4-year interval, those who had higher consumption of total nuts (≥0.5 servings/day) had a lower risk of CVD (RR, 0.75; 95% CI, 0.67–0.84), coronary heart disease (RR, 0.80; 95% CI, 0.69–0.93), and stroke (RR, 0.68; 95% CI, 0.57–0.82) in next 4 years. Individuals who decreased nut consumption by ≥0.50 servings/day had a higher risk of developing CVD (RR, 1.14; 95% CI, 0.99–1.32), coronary heart disease (RR, 1.06; 95% CI, 0.88–1.28), and stroke (RR, 1.28; 95% CI, 1.02–1.60) when compared with those who maintained their nut consumption. CONCLUSIONS: Increasing total consumption of nuts and intake of individual types of nuts (eg, walnuts, other tree nuts, and peanuts) was associated with a subsequent lower risk of CVD. These data support the role of nut intake in the primary prevention of CVD.
KW - Cardiovascular disease
KW - Cohorts
KW - Nuts
KW - Peanuts
KW - Prevention
KW - Stroke
U2 - 10.1161/JAHA.119.013877
DO - 10.1161/JAHA.119.013877
M3 - Journal article
C2 - 32233756
AN - SCOPUS:85082792241
VL - 9
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 7
M1 - e013877
ER -
ID: 357952299