Dietary intake and biomarkers of linoleic acid and mortality: systematic review and meta-analysis of prospective cohort studies
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Dietary intake and biomarkers of linoleic acid and mortality : systematic review and meta-analysis of prospective cohort studies. / Li, Jun; Guasch-Ferré, Marta; Li, Yanping; Hu, Frank B.
In: American Journal of Clinical Nutrition, Vol. 112, No. 1, 2020, p. 150-167.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dietary intake and biomarkers of linoleic acid and mortality
T2 - systematic review and meta-analysis of prospective cohort studies
AU - Li, Jun
AU - Guasch-Ferré, Marta
AU - Li, Yanping
AU - Hu, Frank B
N1 - Copyright © The Author(s) 2020.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Current evidence on associations between intakes of linoleic acid (LA), the predominant n-6 (ω-6) fatty acid, and mortality is inconsistent and has not been summarized by a systematic review and meta-analysis.OBJECTIVE: The aim was to perform a systematic review and meta-analysis of prospective cohort studies to examine associations between LA intake and mortality.METHODS: We conducted a comprehensive search of MEDLINE and EMBASE databases through 31 July 2019 for prospective cohort studies reporting associations of LA (assessed by dietary surveys and/or LA concentrations in adipose tissue or blood compartments) with mortality from all causes, cardiovascular disease (CVD), and cancer. Multivariable-adjusted RRs were pooled using random-effects meta-analysis.RESULTS: Thirty-eight studies reporting 44 prospective cohorts were identified; these included 811,069 participants with dietary intake assessment (170,076 all-cause, 50,786 CVD, and 59,684 cancer deaths) and 65,411 participants with biomarker measurements (9758 all-cause, 6492 CVD, and 1719 cancer deaths). Pooled RRs comparing extreme categories of dietary LA intake (high vs low) were 0.87 (95% CI: 0.81, 0.94; I2 = 67.9%) for total mortality, 0.87 (95% CI: 0.82, 0.92; I2 = 3.7%) for CVD mortality, and 0.89 (95% CI: 0.85, 0.93; I2 = 0%) for cancer mortality. Pooled RRs for each SD increment in LA concentrations in adipose tissue/blood compartments were 0.91 (95% CI: 0.87, 0.95; I2 = 64.1%) for total mortality, 0.89 (95% CI: 0.85, 0.94; I2 = 28.9%) for CVD mortality, and 0.91 (95% CI: 0.84, 0.98; I2 = 26.3%) for cancer mortality. Meta-regressions suggested baseline age and dietary assessment methods as potential sources of heterogeneity for the association between LA and total mortality.CONCLUSIONS: In prospective cohort studies, higher LA intake, assessed by dietary surveys or biomarkers, was associated with a modestly lower risk of mortality from all causes, CVD, and cancer. These data support the potential long-term benefits of PUFA intake in lowering the risk of CVD and premature death.
AB - BACKGROUND: Current evidence on associations between intakes of linoleic acid (LA), the predominant n-6 (ω-6) fatty acid, and mortality is inconsistent and has not been summarized by a systematic review and meta-analysis.OBJECTIVE: The aim was to perform a systematic review and meta-analysis of prospective cohort studies to examine associations between LA intake and mortality.METHODS: We conducted a comprehensive search of MEDLINE and EMBASE databases through 31 July 2019 for prospective cohort studies reporting associations of LA (assessed by dietary surveys and/or LA concentrations in adipose tissue or blood compartments) with mortality from all causes, cardiovascular disease (CVD), and cancer. Multivariable-adjusted RRs were pooled using random-effects meta-analysis.RESULTS: Thirty-eight studies reporting 44 prospective cohorts were identified; these included 811,069 participants with dietary intake assessment (170,076 all-cause, 50,786 CVD, and 59,684 cancer deaths) and 65,411 participants with biomarker measurements (9758 all-cause, 6492 CVD, and 1719 cancer deaths). Pooled RRs comparing extreme categories of dietary LA intake (high vs low) were 0.87 (95% CI: 0.81, 0.94; I2 = 67.9%) for total mortality, 0.87 (95% CI: 0.82, 0.92; I2 = 3.7%) for CVD mortality, and 0.89 (95% CI: 0.85, 0.93; I2 = 0%) for cancer mortality. Pooled RRs for each SD increment in LA concentrations in adipose tissue/blood compartments were 0.91 (95% CI: 0.87, 0.95; I2 = 64.1%) for total mortality, 0.89 (95% CI: 0.85, 0.94; I2 = 28.9%) for CVD mortality, and 0.91 (95% CI: 0.84, 0.98; I2 = 26.3%) for cancer mortality. Meta-regressions suggested baseline age and dietary assessment methods as potential sources of heterogeneity for the association between LA and total mortality.CONCLUSIONS: In prospective cohort studies, higher LA intake, assessed by dietary surveys or biomarkers, was associated with a modestly lower risk of mortality from all causes, CVD, and cancer. These data support the potential long-term benefits of PUFA intake in lowering the risk of CVD and premature death.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Cardiovascular Diseases/drug therapy
KW - Fatty Acids, Omega-6/administration & dosage
KW - Female
KW - Humans
KW - Linoleic Acid/administration & dosage
KW - Male
KW - Middle Aged
KW - Neoplasms/drug therapy
KW - Prospective Studies
KW - Randomized Controlled Trials as Topic
KW - Young Adult
U2 - 10.1093/ajcn/nqz349
DO - 10.1093/ajcn/nqz349
M3 - Journal article
C2 - 32020162
VL - 112
SP - 150
EP - 167
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 1
ER -
ID: 357989009