Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study
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Legume consumption is inversely associated with type 2 diabetes incidence in adults : A prospective assessment from the PREDIMED study. / Becerra-Tomás, Nerea; Díaz-López, Andrés; Rosique-Esteban, Núria; Ros, Emilio; Buil-Cosiales, Pilar; Corella, Dolores; Estruch, Ramon; Fitó, Montserrat; Serra-Majem, Lluís; Arós, Fernando; Lamuela-Raventós, Rosa Maria; Fiol, Miquel; Santos-Lozano, José Manuel; Díez-Espino, Javier; Portoles, Olga; Salas-Salvadó, Jordi; Serra-Mir, M.; Pérez-Heras, A.; Viñas, C.; Casas, R.; Medina-Renom, A.; Baena, J. M.; García, M.; Oller, M.; Amat, J.; Duaso, I.; García, Y.; Iglesias, C.; Simón, C.; Quinzavos, L.; Parra, L.; Liroz, M.; Benavent, J.; Clos, J.; Pla, I.; Amorós, M.; Bonet, M. T.; Martín, M. T.; Sánchez, M. S.; Altirriba, J.; Manzano, E.; Altés, A.; Cofán, M.; Valls-Pedret, C.; Sala-Vila, A.; Martin, F.; Guasch-Ferre, M.; Schröder, H.; García-García, M.; García, L.; PREDIMED Study Investigators.
In: Clinical Nutrition, Vol. 37, No. 3, 2018, p. 906-913.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Legume consumption is inversely associated with type 2 diabetes incidence in adults
T2 - A prospective assessment from the PREDIMED study
AU - Becerra-Tomás, Nerea
AU - Díaz-López, Andrés
AU - Rosique-Esteban, Núria
AU - Ros, Emilio
AU - Buil-Cosiales, Pilar
AU - Corella, Dolores
AU - Estruch, Ramon
AU - Fitó, Montserrat
AU - Serra-Majem, Lluís
AU - Arós, Fernando
AU - Lamuela-Raventós, Rosa Maria
AU - Fiol, Miquel
AU - Santos-Lozano, José Manuel
AU - Díez-Espino, Javier
AU - Portoles, Olga
AU - Salas-Salvadó, Jordi
AU - Serra-Mir, M.
AU - Pérez-Heras, A.
AU - Viñas, C.
AU - Casas, R.
AU - Medina-Renom, A.
AU - Baena, J. M.
AU - García, M.
AU - Oller, M.
AU - Amat, J.
AU - Duaso, I.
AU - García, Y.
AU - Iglesias, C.
AU - Simón, C.
AU - Quinzavos, L.
AU - Parra, L.
AU - Liroz, M.
AU - Benavent, J.
AU - Clos, J.
AU - Pla, I.
AU - Amorós, M.
AU - Bonet, M. T.
AU - Martín, M. T.
AU - Sánchez, M. S.
AU - Altirriba, J.
AU - Manzano, E.
AU - Altés, A.
AU - Cofán, M.
AU - Valls-Pedret, C.
AU - Sala-Vila, A.
AU - Martin, F.
AU - Guasch-Ferre, M.
AU - Schröder, H.
AU - García-García, M.
AU - García, L.
AU - PREDIMED Study Investigators
N1 - Publisher Copyright: © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
PY - 2018
Y1 - 2018
N2 - Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46–0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk. Trial registration: The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.
AB - Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46–0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk. Trial registration: The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.
KW - Legumes
KW - Lentils
KW - PREDIMED-study
KW - Type 2 diabetes
U2 - 10.1016/j.clnu.2017.03.015
DO - 10.1016/j.clnu.2017.03.015
M3 - Journal article
C2 - 28392166
AN - SCOPUS:85017176641
VL - 37
SP - 906
EP - 913
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 3
ER -
ID: 358110847