Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: A randomized controlled trial
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Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk : A randomized controlled trial. / Hernáez, Álvaro; Lassale, Camille; Castro-Barquero, Sara; Ros, Emilio; Tresserra-Rimbau, Anna; Castañer, Olga; Pintó, Xavier; Vázquez-Ruiz, Zenaida; Sorlí, José V.; Salas-Salvadó, Jordi; Lapetra, José; Gómez-Gracia, Enrique; Alonso-Gómez, Ángel M.; Fiol, Miquel; Serra-Majem, Lluis; Sacanella, Emilio; Razquin, Cristina; Corella, Dolores; Guasch-Ferré, Marta; Cofán, Montserrat; Estruch, Ramón.
In: Nutrients, Vol. 13, No. 2, 559, 2021, p. 1-13.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk
T2 - A randomized controlled trial
AU - Hernáez, Álvaro
AU - Lassale, Camille
AU - Castro-Barquero, Sara
AU - Ros, Emilio
AU - Tresserra-Rimbau, Anna
AU - Castañer, Olga
AU - Pintó, Xavier
AU - Vázquez-Ruiz, Zenaida
AU - Sorlí, José V.
AU - Salas-Salvadó, Jordi
AU - Lapetra, José
AU - Gómez-Gracia, Enrique
AU - Alonso-Gómez, Ángel M.
AU - Fiol, Miquel
AU - Serra-Majem, Lluis
AU - Sacanella, Emilio
AU - Razquin, Cristina
AU - Corella, Dolores
AU - Guasch-Ferré, Marta
AU - Cofán, Montserrat
AU - Estruch, Ramón
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
AB - There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
KW - Mediterranean diet
KW - Platelet count
KW - Prevention
KW - Randomized controlled trial
KW - Thrombocytopenia
U2 - 10.3390/nu13020559
DO - 10.3390/nu13020559
M3 - Journal article
C2 - 33567733
AN - SCOPUS:85100548480
VL - 13
SP - 1
EP - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 559
ER -
ID: 357885024