Nut Consumption and Risk of Cardiovascular Disease
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Nut Consumption and Risk of Cardiovascular Disease. / Guasch-Ferré, Marta; Liu, Xiaoran; Malik, Vasanti S.; Sun, Qi; Willett, Walter C.; Manson, Jo Ann E.; Rexrode, Kathryn M.; Li, Yanping; Hu, Frank B.; Bhupathiraju, Shilpa N.
In: Journal of the American College of Cardiology, Vol. 70, No. 20, 2017, p. 2519-2532.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Nut Consumption and Risk of Cardiovascular Disease
AU - Guasch-Ferré, Marta
AU - Liu, Xiaoran
AU - Malik, Vasanti S.
AU - Sun, Qi
AU - Willett, Walter C.
AU - Manson, Jo Ann E.
AU - Rexrode, Kathryn M.
AU - Li, Yanping
AU - Hu, Frank B.
AU - Bhupathiraju, Shilpa N.
N1 - Publisher Copyright: © 2017 American College of Cardiology Foundation
PY - 2017
Y1 - 2017
N2 - Background The associations between specific types of nuts, specifically peanuts and walnuts, and cardiovascular disease remain unclear. Objectives The authors sought to analyze the associations between the intake of total and specific types of nuts and cardiovascular disease, coronary heart disease, and stroke risk. Methods The authors included 76,364 women from the Nurses’ Health Study (1980 to 2012), 92,946 women from the Nurses’ Health Study II (1991 to 2013), and 41,526 men from the Health Professionals Follow-Up Study (1986 to 2012) who were free of cancer, heart disease, and stroke at baseline. Nut consumption was assessed using food frequency questionnaires at baseline and was updated every 4 years. Results During 5,063,439 person-years of follow-up, the authors documented 14,136 incident cardiovascular disease cases, including 8,390 coronary heart disease cases and 5,910 stroke cases. Total nut consumption was inversely associated with total cardiovascular disease and coronary heart disease after adjustment for cardiovascular risk factors. The pooled multivariable hazard ratios for cardiovascular disease and coronary heart disease among participants who consumed 1 serving of nuts (28 g) 5 or more times per week, compared with the reference category (never or almost never), were 0.86 (95% confidence interval: 0.79 to 0.93; p for trend = 0.0002) and 0.80 (95% confidence interval: 0.72 to 0.89; p for trend <0.001), respectively. Consumption of peanuts and tree nuts (2 or more times/week) and walnuts (1 or more times/week) was associated with a 13% to 19% lower risk of total cardiovascular disease and 15% to 23% lower risk of coronary heart disease. Conclusions In 3 large prospective cohort studies, higher consumption of total and specific types of nuts was inversely associated with total cardiovascular disease and coronary heart disease.
AB - Background The associations between specific types of nuts, specifically peanuts and walnuts, and cardiovascular disease remain unclear. Objectives The authors sought to analyze the associations between the intake of total and specific types of nuts and cardiovascular disease, coronary heart disease, and stroke risk. Methods The authors included 76,364 women from the Nurses’ Health Study (1980 to 2012), 92,946 women from the Nurses’ Health Study II (1991 to 2013), and 41,526 men from the Health Professionals Follow-Up Study (1986 to 2012) who were free of cancer, heart disease, and stroke at baseline. Nut consumption was assessed using food frequency questionnaires at baseline and was updated every 4 years. Results During 5,063,439 person-years of follow-up, the authors documented 14,136 incident cardiovascular disease cases, including 8,390 coronary heart disease cases and 5,910 stroke cases. Total nut consumption was inversely associated with total cardiovascular disease and coronary heart disease after adjustment for cardiovascular risk factors. The pooled multivariable hazard ratios for cardiovascular disease and coronary heart disease among participants who consumed 1 serving of nuts (28 g) 5 or more times per week, compared with the reference category (never or almost never), were 0.86 (95% confidence interval: 0.79 to 0.93; p for trend = 0.0002) and 0.80 (95% confidence interval: 0.72 to 0.89; p for trend <0.001), respectively. Consumption of peanuts and tree nuts (2 or more times/week) and walnuts (1 or more times/week) was associated with a 13% to 19% lower risk of total cardiovascular disease and 15% to 23% lower risk of coronary heart disease. Conclusions In 3 large prospective cohort studies, higher consumption of total and specific types of nuts was inversely associated with total cardiovascular disease and coronary heart disease.
KW - cardiovascular disease
KW - coronary heart disease
KW - nuts
KW - peanuts
KW - stroke
KW - tree nuts
U2 - 10.1016/j.jacc.2017.09.035
DO - 10.1016/j.jacc.2017.09.035
M3 - Journal article
C2 - 29145952
AN - SCOPUS:85032702987
VL - 70
SP - 2519
EP - 2532
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 20
ER -
ID: 358107513