Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet
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Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet. / Toledo, Estefanía; Wang, Dong D; Ruiz-Canela, Miguel; Clish, Clary B; Razquin, Cristina; Zheng, Yan; Guasch-Ferré, Marta; Hruby, Adela; Corella, Dolores; Gómez-Gracia, Enrique; Fiol, Miquel; Estruch, Ramón; Ros, Emilio; Lapetra, José; Fito, Montserrat; Aros, Fernando; Serra-Majem, Luis; Liang, Liming; Salas-Salvadó, Jordi; Hu, Frank B; Martínez-González, Miguel A.
In: American Journal of Clinical Nutrition, Vol. 106, No. 4, 2017, p. 973-983.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Plasma lipidomic profiles and cardiovascular events in a randomized intervention trial with the Mediterranean diet
AU - Toledo, Estefanía
AU - Wang, Dong D
AU - Ruiz-Canela, Miguel
AU - Clish, Clary B
AU - Razquin, Cristina
AU - Zheng, Yan
AU - Guasch-Ferré, Marta
AU - Hruby, Adela
AU - Corella, Dolores
AU - Gómez-Gracia, Enrique
AU - Fiol, Miquel
AU - Estruch, Ramón
AU - Ros, Emilio
AU - Lapetra, José
AU - Fito, Montserrat
AU - Aros, Fernando
AU - Serra-Majem, Luis
AU - Liang, Liming
AU - Salas-Salvadó, Jordi
AU - Hu, Frank B
AU - Martínez-González, Miguel A
N1 - © 2017 American Society for Nutrition.
PY - 2017
Y1 - 2017
N2 - Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD).Objective: We evaluated the associations between 1) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3) 1-y changes in lipid species and subsequent CVD.Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)].Results: Baseline concentrations of cholesterol esters (CEs) were inversely associated with CVD. A shorter chain length and higher saturation of some lipids were directly associated with CVD. After adjusting for multiple testing, direct associations remained significant for 20 lipids, and inverse associations remained significant for 6 lipids. When lipid species were weighted by the number of carbon atoms and double bonds, the strongest inverse association was found for CEs [HR: 0.39 (95% CI: 0.22, 0.68)] between extreme quintiles (P-trend = 0.002). Participants in the MedDiet + EVOO and MedDiet + nut groups experienced significant (P < 0.05) 1-y changes in 20 and 17 lipids, respectively, compared with the control group. Of these changes, only those in CE(20:3) in the MedDiet + nuts group remained significant after correcting for multiple testing. None of the 1-y changes was significantly associated with CVD risk after correcting for multiple comparisons.Conclusions: Although the MedDiet interventions induced some significant 1-y changes in the lipidome, they were not significantly associated with subsequent CVD risk. Lipid metabolites with a longer acyl chain and higher number of double bonds at baseline were significantly and inversely associated with the risk of CVD.
AB - Background: Lipid metabolites may partially explain the inverse association between the Mediterranean diet (MedDiet) and cardiovascular disease (CVD).Objective: We evaluated the associations between 1) lipid species and the risk of CVD (myocardial infarction, stroke, or cardiovascular death); 2) a MedDiet intervention [supplemented with extra virgin olive oil (EVOO) or nuts] and 1-y changes in these molecules; and 3) 1-y changes in lipid species and subsequent CVD.Design: With the use of a case-cohort design, we profiled 202 lipid species at baseline and after 1 y of intervention in the PREDIMED (PREvención con DIeta MEDiterránea) trial in 983 participants [230 cases and a random subcohort of 790 participants (37 overlapping cases)].Results: Baseline concentrations of cholesterol esters (CEs) were inversely associated with CVD. A shorter chain length and higher saturation of some lipids were directly associated with CVD. After adjusting for multiple testing, direct associations remained significant for 20 lipids, and inverse associations remained significant for 6 lipids. When lipid species were weighted by the number of carbon atoms and double bonds, the strongest inverse association was found for CEs [HR: 0.39 (95% CI: 0.22, 0.68)] between extreme quintiles (P-trend = 0.002). Participants in the MedDiet + EVOO and MedDiet + nut groups experienced significant (P < 0.05) 1-y changes in 20 and 17 lipids, respectively, compared with the control group. Of these changes, only those in CE(20:3) in the MedDiet + nuts group remained significant after correcting for multiple testing. None of the 1-y changes was significantly associated with CVD risk after correcting for multiple comparisons.Conclusions: Although the MedDiet interventions induced some significant 1-y changes in the lipidome, they were not significantly associated with subsequent CVD risk. Lipid metabolites with a longer acyl chain and higher number of double bonds at baseline were significantly and inversely associated with the risk of CVD.
KW - Aged
KW - Cardiovascular Diseases/blood
KW - Cholesterol Esters/blood
KW - Diet, Mediterranean
KW - Dietary Fats/analysis
KW - Dietary Supplements
KW - Female
KW - Humans
KW - Lipid Metabolism
KW - Lipids/blood
KW - Male
KW - Middle Aged
KW - Nuts
KW - Olive Oil
KW - Risk Factors
U2 - 10.3945/ajcn.116.151159
DO - 10.3945/ajcn.116.151159
M3 - Journal article
C2 - 28814398
VL - 106
SP - 973
EP - 983
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -
ID: 358112448