Protective effects of the mediterranean diet on type 2 diabetes and metabolic syndrome
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Protective effects of the mediterranean diet on type 2 diabetes and metabolic syndrome. / Salas-Salvadó, Jordi; Guasch-Ferré, Marta; Lee, Chih Hao; Estruch, Ramón; Clish, Clary B.; Ros, Emilio.
In: Journal of Nutrition, Vol. 146, No. 4, 2016, p. 920S-927S.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protective effects of the mediterranean diet on type 2 diabetes and metabolic syndrome
AU - Salas-Salvadó, Jordi
AU - Guasch-Ferré, Marta
AU - Lee, Chih Hao
AU - Estruch, Ramón
AU - Clish, Clary B.
AU - Ros, Emilio
N1 - Publisher Copyright: © 2016 American Society for Nutrition.
PY - 2016
Y1 - 2016
N2 - Several studies provide evidence supporting a beneficial effect from the traditionalMediterranean diet (MedDiet) on the risk of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). This review summarizes the current scientific evidence from epidemiologic studies and clinical trials on the relation between the MedDiet and T2DM and MetS and the possible mechanisms underlying the reported associations. A recent meta-analysis of prospective cohort studies showed that greater adherence to the MedDietwas associated with a significant reduction in the risk of diabetes. The MedDiet has also been found to be beneficial in the prevention of gestational diabetes. Four large prospective studies have observed inverse associations between the MedDiet and MetS or its components. Few randomized controlled trials (RCTs) have evaluated the effect of th eMedDiet on T2DM and MetS. Results from the landmark PREvención con DIeta MEDiterránea (PREDIMED) nutrition intervention trial showed that participants assigned to the MedDiet had a significant30%reduction in the risk ofT2DMand that it also promoted the reversion of MetS and its components, hyperglycemia and central obesity. In addition, 5 RCTs showed the beneficial effects of the MedDiet comparedwith other dietary patterns on glycemic control in patients with T2DM. A recent meta-analysis of RCTs revealed that, compared with a variety of control diets, the MedDiet was associated with beneficial effects on all MetS components. Bioactive components of the MedDiet synergize to affect variousmetabolic pathways, leading to a reduced cardiometabolic disease risk. The abundance of healthy, nutrient-dense foods thatmakeup the plant-basedMedDiet predicts its bioactivity and potential to beneficially influence metabolic pathwaysthat lead to MetS and T2DM, aswell asother chronicconditions.Abundantepidemiologic andclinical trial evidence supports the role of the MedDiet on the prevention and management of T2DM and MetS.
AB - Several studies provide evidence supporting a beneficial effect from the traditionalMediterranean diet (MedDiet) on the risk of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS). This review summarizes the current scientific evidence from epidemiologic studies and clinical trials on the relation between the MedDiet and T2DM and MetS and the possible mechanisms underlying the reported associations. A recent meta-analysis of prospective cohort studies showed that greater adherence to the MedDietwas associated with a significant reduction in the risk of diabetes. The MedDiet has also been found to be beneficial in the prevention of gestational diabetes. Four large prospective studies have observed inverse associations between the MedDiet and MetS or its components. Few randomized controlled trials (RCTs) have evaluated the effect of th eMedDiet on T2DM and MetS. Results from the landmark PREvención con DIeta MEDiterránea (PREDIMED) nutrition intervention trial showed that participants assigned to the MedDiet had a significant30%reduction in the risk ofT2DMand that it also promoted the reversion of MetS and its components, hyperglycemia and central obesity. In addition, 5 RCTs showed the beneficial effects of the MedDiet comparedwith other dietary patterns on glycemic control in patients with T2DM. A recent meta-analysis of RCTs revealed that, compared with a variety of control diets, the MedDiet was associated with beneficial effects on all MetS components. Bioactive components of the MedDiet synergize to affect variousmetabolic pathways, leading to a reduced cardiometabolic disease risk. The abundance of healthy, nutrient-dense foods thatmakeup the plant-basedMedDiet predicts its bioactivity and potential to beneficially influence metabolic pathwaysthat lead to MetS and T2DM, aswell asother chronicconditions.Abundantepidemiologic andclinical trial evidence supports the role of the MedDiet on the prevention and management of T2DM and MetS.
KW - Cardiovascular disease
KW - Diabetes
KW - Mediterranean diet
KW - Metabolic syndrome
KW - Metabolic syndrome components
KW - Review
U2 - 10.3945/jn.115.218487
DO - 10.3945/jn.115.218487
M3 - Journal article
AN - SCOPUS:84963812026
VL - 146
SP - 920S-927S
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 4
ER -
ID: 358502388