Niels Grarup

Obesity and unfavourable lifestyle increase type 2 diabetes-risk independent of genetic predisposition

Jakupovic, Hermina, Schnurr, T. M., Carrasquilla, Germán D., Grarup, Niels, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Pedersen, Oluf Borbye, Hansen, Torben & Kilpeläinen, Tuomas O., 2019, In: Diabetologia. 62, Suppl. 1, p. S188 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Schmidt, A. F., Holmes, M. V., Preiss, D., Swerdlow, D. I., Denaxas, S., Fatemifar, G., Faraway, R., Finan, C., Valentine, D., Fairhurst-Hunter, Z., Hartwig, F. P., Horta, B. L., Hypponen, E., Power, C., Moldovan, M., Van Iperen, E., Hovingh, K., Demuth, I., Norman, K., Steinhagen-Thiessen, E. & 145 others, Demuth, J., Bertram, L., Lill, C. M., Coassin, S., Willeit, J., Kiechl, S., Willeit, K., Mason, D., Wright, J., Morris, R., Wanamethee, G., Whincup, P., Ben-Shlomo, Y., McLachlan, S., Price, J. F., Kivimaki, M., Welch, C., Sanchez-Galvez, A., Marques-Vidal, P., Nicolaides, A., Panayiotou, A. G., Onland-Moret, N. C., Van Der Schouw, Y. T., Matullo, G., Fiorito, G., Guarrera, S., Sacerdote, C., Wareham, N. J., Langenberg, C., Scott, R. A., Luan, J., Bobak, M., Malyutina, S., Pajak, A., Kubinova, R., Tamosiunas, A., Pikhart, H., Grarup, Niels, Pedersen, Oluf Borbye, Hansen, Torben, Linneberg, Allan René, Jess, T., Cooper, J., Humphries, S. E., Brilliant, M., Kitchner, T., Hakonarson, H., Carrell, D. S., McCarty, C. A., Lester, K. H., Larson, E. B., Crosslin, D. R., De Andrade, M., Roden, D. M., Denny, J. C., Carty, C., Hancock, S., Attia, J., Holliday, E., Scott, R., Schofield, P., O'Donnell, M., Yusuf, S., Chong, M., Pare, G., Van Der Harst, P., Said, M. A., Eppinga, R. N., Verweij, N., Snieder, H., Christen, T., Mook-Kanamori, D. O., Gustafsson, S., Lind, L., Ingelsson, E., Pazoki, R., Franco, O., Hofman, A., Uitterlinden, A., Dehghan, A., Teumer, A., Baumeister, S., Dörr, M., Lerch, M. M., Völker, U., Völzke, H., Ward, J., Pell, J. P., Meade, T., Christophersen, I. E., Maitland-Van Der Zee, A. H., Baranova, E. V., Young, R., Ford, I., Campbell, A., Padmanabhan, S., Bots, M. L., Grobbee, D. E., Froguel, P., Thuillier, D., Roussel, R., Bonnefond, A., Cariou, B., Smart, M., Bao, Y., Kumari, M., Mahajan, A., Hopewell, J. C., Seshadri, S., Dale, C., Costa, R. P. E., Ridker, P. M., Chasman, D. I., Reiner, A. P., Ritchie, M. D., Lange, L. A., Cornish, A. J., Dobbins, S. E., Hemminki, K., Kinnersley, B., Sanson, M., Labreche, K., Simon, M., Bondy, M., Law, P., Speedy, H., Allan, J., Li, N., Went, M., Weinhold, N., Morgan, G., Sonneveld, P., Nilsson, B., Goldschmidt, H., Sud, A., Engert, A., Hansson, M., Hemingway, H., Asselbergs, F. W., Patel, R. S., Keating, B. J., Sattar, N., Houlston, R., Casas, J. P. & Hingorani, A. D., 2019, In: BMC Cardiovascular Disorders. 19, 1, 10 p., 240.

Research output: Contribution to journal › Journal article › Research › peer-review

Polygenic predisposition to breast cancer and the risk of coronary artery disease

D'Souza, M., Schou, Morten, Skals, R., Weeke, P. E., Lee, C., Smedegaard, L., Madelaire, C., Gerds, Thomas Alexander, Poulsen, Henrik Enghusen, Hansen, Torben, Grarup, Niels, Pedersen, Oluf Borbye, Stender, Steen, Engstrøm, Thomas, Fosbøl, E., Nielsen, D., Gislason, Gunnar Hilmar, Køber, Lars Valeur, Torp-Pedersen, C. & Andersson, C., 2019, In: International Journal of Cardiology. 291, p. 145-151 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., Turcot, V., Auer, P. L., Fine, R. S., Guo, X., Schurmann, C., Lempradl, A., Marouli, E., Mahajan, A., Winkler, T. W., Locke, A. E., Medina-Gomez, C., Esko, T., Vedantam, S., Giri, A. & 31 others, Lo, K. S., Alfred, T., Mudgal, P., Ng, M. C. Y., Heard-Costa, N. L., Feitosa, M. F., Manning, A. K., Willems, S. M., Sivapalaratnam, S., Abecasis, G., Alam, D. S., Allison, M., Amouyel, P., Arzumanyan, Z., Balkau, B., Bork-Jensen, J., Grarup, Niels, Hansen, Torben, Jørgensen, T., Justesen, Johanne Marie, Karpe, F., Kovacs, P., Li, J., Lind, L., Linneberg, Allan René, Pedersen, Oluf Borbye, Pers, Tune H, drb459, drb459, Zhao, J. H., Loos, R. J. F. & CHD Exome+ Consortium, C. E. C., 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis

Merino, J., Guasch-Ferré, M., Ellervik, C., Dashti, H. S., Sharp, S. J., Wu, P., Overvad, K., Sarnowski, C., Kuokkanen, M., Lemaitre, R. N., Justice, A. E., Ericson, U., Braun, K. V. E., Mahendran, Y., Frazier-Wood, A. C., Sun, D., Chu, A. Y., Tanaka, T., Luan, J., Hong, J. & 48 others, Tjønneland, Anne, Ding, M., Lundqvist, A., Mukamal, K., Rohde, R., Schulz, C., Franco, O. H., Grarup, Niels, Chen, Y. I., Bazzano, L., Franks, P. W., Buring, J. E., Langenberg, C., Liu, C., Hansen, Torben, Jensen, Majken Karoline, Sääksjärvi, K., Psaty, B. M., Young, K. L., Hindy, G., Sandholt, C. H., Ridker, P. M., Ordovas, J. M., Meigs, J. B., Pedersen, Oluf Borbye, Kraft, P., Perola, M., North, K. E., Orho-Melander, M., Voortman, T., Toft, Ulla Marie Nørgaard, Rotter, J. I., Qi, L., Forouhi, N. G., Mozaffarian, D., Sørensen, Thorkild I.A., Stampfer, M. J., Männistö, S., Selvin, E., Imamura, F., Salomaa, V., Hu, F. B., Wareham, N. J., Dupuis, J., Smith, C. E., Kilpeläinen, Tuomas O., Chasman, D. I. & Florez, J. C., 2019, In: BMJ (Clinical research ed.). 366, p. l4292

Research output: Contribution to journal › Journal article › Research › peer-review

Screening of 31 genes involved in monogenic forms of obesity in 23 Pakistani probands with early-onset childhood obesity: a case report

Niazi, R. K., Gjesing, A. P., Hollensted, M., Have, C. T., Borisevich, D., Grarup, Niels, Pedersen, Oluf Borbye, Ullah, A., Shahid, G., Shafqat, I., Gul, A. & Hansen, Torben, 2019, In: B M C Medical Genetics. 20, 8 p., 152.

Research output: Contribution to journal › Journal article › Research › peer-review

Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants

Sun, J., Have, C. T., Hollensted, M., Grarup, Niels, Linneberg, Allan René, Pedersen, Oluf Borbye, Nielsen, J. S., Rungby, Jørgen, Christensen, C., Brandslund, I., Kristiansen, Karsten, Jun, W., Hansen, Torben & Gjesing, A. P., 2019, In: PLoS ONE. 14, 8, 10 p., e0220805.

Research output: Contribution to journal › Journal article › Research › peer-review

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

Middeldorp, C. M., Mahajan, A., Horikoshi, M., Robertson, N. R., Beaumont, R. N., Bradfield, J. P., Bustamante, M., Cousminer, D. L., Day, F. R., De Silva, N. M., Guxens, M., Mook-Kanamori, D. O., St Pourcain, B., Warrington, N. M., Adair, L. S., Ahlqvist, E., Ahluwalia, T. S., Almgren, P., Ang, W., Atalay, M. & 463 others, Auvinen, J., Bartels, M., Beckmann, J. S., Bilbao, J. R., Bond, T., Borja, J. B., Cavadino, A., Charoen, P., Chen, Z., Coin, L., Cooper, C., Curtin, J. A., Custovic, A., Das, S., Davies, G. E., Dedoussis, G. V., Duijts, L., Eastwood, P. R., Eliasen, A. U., Elliott, P., Eriksson, J. G., Estivill, X., Fadista, J., Fedko, I. O., Frayling, T. M., Gaillard, R., Gauderman, W. J., Geller, F., Gilliland, F., Gilsanz, V., Granell, R., Grarup, Niels, Groop, L., Hadley, D., Hakonarson, H., Hansen, Torben, Hartman, C. A., Hattersley, A. T., Hayes, M. G., Hebebrand, J., Heinrich, J., Helgeland, O., Henders, A. K., Henderson, J., Henriksen, T. B., Hirschhorn, J. N., Hivert, M., Hocher, B., Holloway, J. W., Holt, P., Hottenga, J., Hypponen, E., Iniguez, C., Johansson, S., Jugessur, A., Kahonen, M., Kalkwarf, H. J., Kaprio, J., Karhunen, V., Kemp, J. P., Kerkhof, M., Koppelman, G. H., Korner, A., Kotecha, S., Kreiner-Moller, E., Kulohoma, B., Kumar, A., Kutalik, Z., Lahti, J., Lappe, J. M., Larsson, H., Lehtimaki, T., Lewin, A. M., Li, J., Lichtenstein, P., Lindgren, C. M., Lindi, V., Linneberg, Allan René, Liu, X., Liu, J., Lowe, W. L. ,. J., Lundstrom, S., Lyytikainen, L., Ma, R. C. W., Mace, A., Magi, R., Magnus, P., Mamun, A. A., Mannikko, M., Martin, N. G., Mbarek, H., McCarthy, N. S., Medland, S. E., Melbye, M., Melen, E., Mohlke, K. L., Monnereau, C., Morgen, C. S., Morris, A. P., Murray, J. C., Myhre, R., Najman, J. M., Nivard, M. G., Nohr, E. A., Nolte, I. M., Ntalla, I., O'Reilly, P., Oberfield, S. E., Oken, E., Oldehinkel, A. J., Pahkala, K., Palviainen, T., Panoutsopoulou, K., Pedersen, Oluf Borbye, Pennell, C. E., Pershagen, G., Pitkanen, N., Plomin, R., Power, C., Prasad, R. B., Prokopenko, I., Pulkkinen, L., Raikkonen, K., Raitakari, O. T., Reynolds, R. M., Richmond, R. C., Rivadeneira, F., Rodriguez, A., Rose, R. J., Salem, R., Santa-Marina, L., Saw, S., Schnurr, T. M., Scott, J. G., Selzam, S., Shepherd, J. A., Simpson, A., Skotte, L., Sleiman, P. M. A., Snieder, H., Sørensen, Thorkild I.A., Standl, M., Steegers, E. A. P., Strachan, D. P., Straker, L., Strandberg, T., Taylor, M., Teo, Y., Thiering, E., Torrent, M., Tyrrell, J., Uitterlinden, A. G., van Beijsterveldt, T., van der Most, P. J., van Duijn, C. M., Viikari, J., Vilor-Tejedor, N., Vogelezang, S., Vonk, J. M., Vrijkotte, T. G. M., Vuoksimaa, E., Wang, C. A., Watkins, W. J., Wichmann, H., Willemsen, G., Williams, G. M., Wilson, J. F., Wray, N. R., Xu, S., Xu, C., Yaghootkar, H., Yi, L., Zafarmand, M. H., Zeggini, E., Zemel, B. S., Hinney, A., Lakka, T. A., Whitehouse, A. J. O., Sunyer, J., Widen, E. E., Feenstra, B., Sebert, S., Jacobsson, B., Njolstad, P. R., Stoltenberg, C., Smith, G. D., Lawlor, D. A., Paternoster, L., Timpson, N. J., Ong, K. K., Bisgaard, H., Bønnelykke, Klaus, Jaddoe, V. W. V., Tiemeier, H., Jarvelin, M., Evans, D. M., Perry, J. R. B., Grant, S. F. A., Boomsma, D. I., Freathy, R. M., McCarthy, M. I., Adair, L. S., Ahlqvist, E., Ahluwalia, Tarun Veer Singh, Almgren, P., Ang, W., Atalay, M., Beaumont, R. N., Beckmann, J. S., Bisgaard, H., Bond, T., Bønnelykke, Klaus, Boomsma, D. I., Borja, J. B., Bradfield, J. P., Bustamante, M., Cavadino, A., Charoen, P., Coin, L., Cooper, C., Cousminer, D. L., Curtin, J. A., Custovic, A., Das, S., Day, F. R., De Silva, N. M., Dedoussis, G. V., Elliott, P., Eriksson, J. G., Evans, D. M., Fadista, J., Feenstra, B., Felix, J. F., Frayling, T. M., Freathy, R. M., Gaillard, R., Geller, F., Gilsanz, V., Grant, S. F. A., Grarup, Niels, Groop, L., Guxens, M., Hadley, D., Hakonarson, H., Hansen, Torben, Hattersley, A. T., Hayes, M. G., Hebebrand, J., Heinrich, J., Helgeland, O., Henriksen, T. B., Hinney, A., Hirschhorn, J. N., Hivert, M., Hocher, B., Holloway, J. W., Horikoshi, M., Hottenga, J., Hypponen, E., Jacobsson, B., Jaddoe, V. W. V., Jarvelin, M., Johansson, S., Kalkwarf, H. J., Kerkhof, M., Korner, A., Kotecha, S., Kreiner-Moller, E., Kulohoma, B., Kutalik, Z., Lakka, T. A., Lappe, J. M., Lawlor, D. A., Lehtimaki, T., Lewin, A. M., Lindgren, C. M., Lindi, V., Linneberg, Allan René, Liu, X., Liu, J., Lowe, W. L. ,. J., Ma, R. C. W., Mace, A., Magi, R., Magnus, P., Mahajan, A., McCarthy, N. S., McCarthy, M. I., Melbye, M., Mohlke, K. L., Monnereau, C., Mook-Kanamori, D. O., Morgen, C. S., Morris, A. P., Murray, J. C., Myhre, R., Njolstad, P. R., Nohr, E. A., Ntalla, I., O'Reilly, P., Oberfield, S. E., Oken, E., Ong, K. K., Panoutsopoulou, K., Pedersen, Oluf Borbye, Pennell, C. E., Perry, J. R. B., Pitkanen, N., St Pourcain, B., Power, C., Prasad, R. B., Prokopenko, I., Raitakari, O. T., Reynolds, R. M., Richmond, R. C., Rodriguez, A., Salem, R., Saw, S., Schnurr, T. M., Sebert, S., Shepherd, J. A., Simpson, A., Skotte, L., Sørensen, Thorkild I.A., Standl, M., Steegers, E. A. P., Strachan, D. P., Sunyer, J., Taylor, M., Teo, Y., Thiering, E., Timpson, N. J., Tyrrell, J., Uitterlinden, A. G., van Duijn, C. M., Vogelezang, S., Vrijkotte, T. G. M., Wang, C. A., Warrington, N. M., Watkins, W. J., Wichmann, H., Widen, E. E., Willemsen, G., Wilson, J. F., Yaghootkar, H., Zafarmand, M. H., Zeggini, E., Zemel, B. S., Ahluwalia, T. S., Auvinen, J., Bartels, M., Bilbao, J. R., Bisgaard, H., Bønnelykke, Klaus, Boomsma, D. I., Bradfield, J. P., Bustamante, M., Chen, Z., Curtin, J. A., Custovic, A., Smith, G. D., Davies, G. E., Duijts, L., Eastwood, P. R., Eliasen, A. U., Estivill, X., Evans, D. M., Fedko, I. O., Felix, J. F., Gauderman, W. J., Gilliland, F., Granell, R., Grant, S. F. A., Guxens, M., Hakonarson, H., Hartman, C. A., Heinrich, J., Henders, A. K., Henderson, J., Holt, P., Hottenga, J., Hypponen, E., Iniguez, C., Jacobsson, B., Jaddoe, V. W. V., Jarvelin, M., Jugessur, A., Kahonen, M., Kaprio, J., Karhunen, V., Kemp, J. P., Koppelman, G. H., Kumar, A., Lahti, J., Larsson, Henrik Bo Wiberg, Lawlor, D. A., Lehtimaki, T., Li, J., Lichtenstein, P., Lundstrom, S., Lyytikainen, L., Magnus, P., Mamun, A. A., Mannikko, M., Martin, N. G., Mbarek, H., Medland, S. E., Melen, E., Middeldorp, C. M., Najman, J. M., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pahkala, K., Palviainen, T., Paternoster, L., Pennell, C. E., Pershagen, G., Pitkanen, N., Plomin, R., St Pourcain, B., Power, C., Pulkkinen, L., Raikkonen, K., Raitakari, O. T., Richmond, R. C., Rivadeneira, F., Rose, R. J., Santa-Marina, L., Scott, J. G., Sebert, S., Selzam, S., Simpson, A., Sleiman, P. M. A., Snieder, H., Standl, M., Stoltenberg, C., Strachan, D. P., Straker, L., Strandberg, T., Sunyer, J., Thiering, E., Tiemeier, H., Timpson, N. J., Torrent, M., Uitterlinden, A. G., van Beijsterveldt, T., van der Most, P. J., van Duijn, C. M., Viikari, J., Vilor-Tejedor, N., Vonk, J. M., Vrijkotte, T. G. M., Vuoksimaa, E., Wang, C. A., Whitehouse, A. J. O., Willemsen, G., Williams, G. M., Wray, N. R., Xu, S., Xu, C., Yi, L. & Zafarmand, M. H., 2019, In: European Journal of Epidemiology. 34, 3, p. 279-300 22 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Broad Genomics Platform, B. G. P., Jun 2019, In: Nature. 570, 7759, p. 71-76 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

et al., E. A. & Warren, H. R., 25 Jun 2019, In: Journal of the American College of Cardiology. 73, 24, p. 3118-3131

Research output: Contribution to journal › Journal article › Research › peer-review