A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol

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Standard

A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. / Surakka, Ida; Whitfield, John B; Perola, Markus; Visscher, Peter M; Montgomery, Grant W; Falchi, Mario; Willemsen, Gonneke; de Geus, Eco J C; Magnusson, Patrik K E; Christensen, Kaare; Sørensen, Thorkild I A; Pietiläinen, Kirsi H; Rantanen, Taina; Silander, Kaisa; Widén, Elisabeth; Muilu, Juha; Rahman, Iffat; Liljedahl, Ulrika; Syvänen, Ann-Christine; Palotie, Aarno; Kaprio, Jaakko; Kyvik, Kirsten Ohm; Pedersen, Nancy L; Boomsma, Dorret I; Spector, Tim; Martin, Nicholas G; Ripatti, Samuli; Peltonen, Leena; GenomEUtwin Project.

In: Twin Research and Human Genetics, Vol. 15, No. 6, 2012, p. 691-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Surakka, I, Whitfield, JB, Perola, M, Visscher, PM, Montgomery, GW, Falchi, M, Willemsen, G, de Geus, EJC, Magnusson, PKE, Christensen, K, Sørensen, TIA, Pietiläinen, KH, Rantanen, T, Silander, K, Widén, E, Muilu, J, Rahman, I, Liljedahl, U, Syvänen, A-C, Palotie, A, Kaprio, J, Kyvik, KO, Pedersen, NL, Boomsma, DI, Spector, T, Martin, NG, Ripatti, S, Peltonen, L & GenomEUtwin Project 2012, 'A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol', Twin Research and Human Genetics, vol. 15, no. 6, pp. 691-9. https://doi.org/10.1017/thg.2012.63

APA

Surakka, I., Whitfield, J. B., Perola, M., Visscher, P. M., Montgomery, G. W., Falchi, M., Willemsen, G., de Geus, E. J. C., Magnusson, P. K. E., Christensen, K., Sørensen, T. I. A., Pietiläinen, K. H., Rantanen, T., Silander, K., Widén, E., Muilu, J., Rahman, I., Liljedahl, U., Syvänen, A-C., ... GenomEUtwin Project (2012). A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Research and Human Genetics, 15(6), 691-9. https://doi.org/10.1017/thg.2012.63

Vancouver

Surakka I, Whitfield JB, Perola M, Visscher PM, Montgomery GW, Falchi M et al. A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Research and Human Genetics. 2012;15(6):691-9. https://doi.org/10.1017/thg.2012.63

Author

Surakka, Ida ; Whitfield, John B ; Perola, Markus ; Visscher, Peter M ; Montgomery, Grant W ; Falchi, Mario ; Willemsen, Gonneke ; de Geus, Eco J C ; Magnusson, Patrik K E ; Christensen, Kaare ; Sørensen, Thorkild I A ; Pietiläinen, Kirsi H ; Rantanen, Taina ; Silander, Kaisa ; Widén, Elisabeth ; Muilu, Juha ; Rahman, Iffat ; Liljedahl, Ulrika ; Syvänen, Ann-Christine ; Palotie, Aarno ; Kaprio, Jaakko ; Kyvik, Kirsten Ohm ; Pedersen, Nancy L ; Boomsma, Dorret I ; Spector, Tim ; Martin, Nicholas G ; Ripatti, Samuli ; Peltonen, Leena ; GenomEUtwin Project. / A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. In: Twin Research and Human Genetics. 2012 ; Vol. 15, No. 6. pp. 691-9.

Bibtex

@article{bdee6c4c303b4ee4b830b330d8803be7,
title = "A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol",
abstract = "Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8).",
author = "Ida Surakka and Whitfield, {John B} and Markus Perola and Visscher, {Peter M} and Montgomery, {Grant W} and Mario Falchi and Gonneke Willemsen and {de Geus}, {Eco J C} and Magnusson, {Patrik K E} and Kaare Christensen and S{\o}rensen, {Thorkild I A} and Pietil{\"a}inen, {Kirsi H} and Taina Rantanen and Kaisa Silander and Elisabeth Wid{\'e}n and Juha Muilu and Iffat Rahman and Ulrika Liljedahl and Ann-Christine Syv{\"a}nen and Aarno Palotie and Jaakko Kaprio and Kyvik, {Kirsten Ohm} and Pedersen, {Nancy L} and Boomsma, {Dorret I} and Tim Spector and Martin, {Nicholas G} and Samuli Ripatti and Leena Peltonen and S{\o}rensen, {Thorkild I.A.}",
year = "2012",
doi = "10.1017/thg.2012.63",
language = "English",
volume = "15",
pages = "691--9",
journal = "Acta Geneticae Medicae et Gemellologiae",
issn = "1832-4274",
publisher = "Cambridge University Press",
number = "6",

}

RIS

TY - JOUR

T1 - A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol

AU - Surakka, Ida

AU - Whitfield, John B

AU - Perola, Markus

AU - Visscher, Peter M

AU - Montgomery, Grant W

AU - Falchi, Mario

AU - Willemsen, Gonneke

AU - de Geus, Eco J C

AU - Magnusson, Patrik K E

AU - Christensen, Kaare

AU - Sørensen, Thorkild I A

AU - Pietiläinen, Kirsi H

AU - Rantanen, Taina

AU - Silander, Kaisa

AU - Widén, Elisabeth

AU - Muilu, Juha

AU - Rahman, Iffat

AU - Liljedahl, Ulrika

AU - Syvänen, Ann-Christine

AU - Palotie, Aarno

AU - Kaprio, Jaakko

AU - Kyvik, Kirsten Ohm

AU - Pedersen, Nancy L

AU - Boomsma, Dorret I

AU - Spector, Tim

AU - Martin, Nicholas G

AU - Ripatti, Samuli

AU - Peltonen, Leena

AU - GenomEUtwin Project

PY - 2012

Y1 - 2012

N2 - Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8).

AB - Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8).

U2 - 10.1017/thg.2012.63

DO - 10.1017/thg.2012.63

M3 - Journal article

C2 - 23031429

VL - 15

SP - 691

EP - 699

JO - Acta Geneticae Medicae et Gemellologiae

JF - Acta Geneticae Medicae et Gemellologiae

SN - 1832-4274

IS - 6

ER -

ID: 48585283