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A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. / Bouatia-Naji, Nabila; Bonnefond, Amélie; Cavalcanti-Proença, Christine; Sparsø, Thomas; Holmkvist, Johan; Marchand, Marion; Delplanque, Jérôme; Lobbens, Stéphane; Rocheleau, Ghislain; Durand, Emmanuelle; De Graeve, Franck; Chèvre, Jean-Claude; Borch-Johnsen, Knut; Hartikainen, Anna-Liisa; Ruokonen, Aimo; Tichet, Jean; Marre, Michel; Weill, Jacques; Heude, Barbara; Tauber, Maithé; Lemaire, Katleen; Schuit, Frans; Elliott, Paul; Jørgensen, Torben; Charpentier, Guillaume; Hadjadj, Samy; Cauchi, Stéphane; Vaxillaire, Martine; Sladek, Robert; Visvikis-Siest, Sophie; Balkau, Beverley; Lévy-Marchal, Claire; Pattou, François; Meyre, David; Blakemore, Alexandra I F; Jarvelin, Marjo-Riita; Walley, Andrew J; Hansen, Torben; Dina, Christian; Pedersen, Oluf; Froguel, Philippe.
In:
Nature Genetics, Vol. 41, No. 1, 2009, p. 89-94.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Bouatia-Naji, N, Bonnefond, A, Cavalcanti-Proença, C, Sparsø, T, Holmkvist, J, Marchand, M, Delplanque, J, Lobbens, S, Rocheleau, G, Durand, E, De Graeve, F, Chèvre, J-C, Borch-Johnsen, K, Hartikainen, A-L, Ruokonen, A, Tichet, J, Marre, M, Weill, J, Heude, B, Tauber, M, Lemaire, K, Schuit, F, Elliott, P, Jørgensen, T, Charpentier, G, Hadjadj, S, Cauchi, S, Vaxillaire, M, Sladek, R, Visvikis-Siest, S, Balkau, B, Lévy-Marchal, C, Pattou, F, Meyre, D, Blakemore, AIF, Jarvelin, M-R, Walley, AJ
, Hansen, T, Dina, C
, Pedersen, O & Froguel, P 2009, '
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk',
Nature Genetics, vol. 41, no. 1, pp. 89-94.
https://doi.org/10.1038/ng.277APA
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., De Graeve, F., Chèvre, J-C., Borch-Johnsen, K., Hartikainen, A-L., Ruokonen, A., Tichet, J., Marre, M., Weill, J., Heude, B., ... Froguel, P. (2009).
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
Nature Genetics,
41(1), 89-94.
https://doi.org/10.1038/ng.277Vancouver
Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, Marchand M et al.
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
Nature Genetics. 2009;41(1):89-94.
https://doi.org/10.1038/ng.277Author
Bouatia-Naji, Nabila ; Bonnefond, Amélie ; Cavalcanti-Proença, Christine ; Sparsø, Thomas ; Holmkvist, Johan ; Marchand, Marion ; Delplanque, Jérôme ; Lobbens, Stéphane ; Rocheleau, Ghislain ; Durand, Emmanuelle ; De Graeve, Franck ; Chèvre, Jean-Claude ; Borch-Johnsen, Knut ; Hartikainen, Anna-Liisa ; Ruokonen, Aimo ; Tichet, Jean ; Marre, Michel ; Weill, Jacques ; Heude, Barbara ; Tauber, Maithé ; Lemaire, Katleen ; Schuit, Frans ; Elliott, Paul ; Jørgensen, Torben ; Charpentier, Guillaume ; Hadjadj, Samy ; Cauchi, Stéphane ; Vaxillaire, Martine ; Sladek, Robert ; Visvikis-Siest, Sophie ; Balkau, Beverley ; Lévy-Marchal, Claire ; Pattou, François ; Meyre, David ; Blakemore, Alexandra I F ; Jarvelin, Marjo-Riita ; Walley, Andrew J ; Hansen, Torben ; Dina, Christian ; Pedersen, Oluf ; Froguel, Philippe. / A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. In: Nature Genetics. 2009 ; Vol. 41, No. 1. pp. 89-94.
Bibtex
@article{bbef570019ea11deb43e000ea68e967b,
title = "A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk",
abstract = "In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway.",
author = "Nabila Bouatia-Naji and Am{\'e}lie Bonnefond and Christine Cavalcanti-Proen{\c c}a and Thomas Spars{\o} and Johan Holmkvist and Marion Marchand and J{\'e}r{\^o}me Delplanque and St{\'e}phane Lobbens and Ghislain Rocheleau and Emmanuelle Durand and {De Graeve}, Franck and Jean-Claude Ch{\`e}vre and Knut Borch-Johnsen and Anna-Liisa Hartikainen and Aimo Ruokonen and Jean Tichet and Michel Marre and Jacques Weill and Barbara Heude and Maith{\'e} Tauber and Katleen Lemaire and Frans Schuit and Paul Elliott and Torben J{\o}rgensen and Guillaume Charpentier and Samy Hadjadj and St{\'e}phane Cauchi and Martine Vaxillaire and Robert Sladek and Sophie Visvikis-Siest and Beverley Balkau and Claire L{\'e}vy-Marchal and Fran{\c c}ois Pattou and David Meyre and Blakemore, {Alexandra I F} and Marjo-Riita Jarvelin and Walley, {Andrew J} and Torben Hansen and Christian Dina and Oluf Pedersen and Philippe Froguel",
note = "Keywords: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Blood Glucose; Child; Chromosomes, Human, Pair 11; Cohort Studies; Diabetes Mellitus, Type 2; Fasting; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Glucokinase; Humans; Insulin Resistance; Islets of Langerhans; Meta-Analysis as Topic; Middle Aged; Polymorphism, Single Nucleotide; RNA, Messenger; Receptor, Melatonin, MT2; Receptors, Melatonin; Reproducibility of Results",
year = "2009",
doi = "10.1038/ng.277",
language = "English",
volume = "41",
pages = "89--94",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
AU - Bouatia-Naji, Nabila
AU - Bonnefond, Amélie
AU - Cavalcanti-Proença, Christine
AU - Sparsø, Thomas
AU - Holmkvist, Johan
AU - Marchand, Marion
AU - Delplanque, Jérôme
AU - Lobbens, Stéphane
AU - Rocheleau, Ghislain
AU - Durand, Emmanuelle
AU - De Graeve, Franck
AU - Chèvre, Jean-Claude
AU - Borch-Johnsen, Knut
AU - Hartikainen, Anna-Liisa
AU - Ruokonen, Aimo
AU - Tichet, Jean
AU - Marre, Michel
AU - Weill, Jacques
AU - Heude, Barbara
AU - Tauber, Maithé
AU - Lemaire, Katleen
AU - Schuit, Frans
AU - Elliott, Paul
AU - Jørgensen, Torben
AU - Charpentier, Guillaume
AU - Hadjadj, Samy
AU - Cauchi, Stéphane
AU - Vaxillaire, Martine
AU - Sladek, Robert
AU - Visvikis-Siest, Sophie
AU - Balkau, Beverley
AU - Lévy-Marchal, Claire
AU - Pattou, François
AU - Meyre, David
AU - Blakemore, Alexandra I F
AU - Jarvelin, Marjo-Riita
AU - Walley, Andrew J
AU - Hansen, Torben
AU - Dina, Christian
AU - Pedersen, Oluf
AU - Froguel, Philippe
N1 - Keywords: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Blood Glucose; Child; Chromosomes, Human, Pair 11; Cohort Studies; Diabetes Mellitus, Type 2; Fasting; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Glucokinase; Humans; Insulin Resistance; Islets of Langerhans; Meta-Analysis as Topic; Middle Aged; Polymorphism, Single Nucleotide; RNA, Messenger; Receptor, Melatonin, MT2; Receptors, Melatonin; Reproducibility of Results
PY - 2009
Y1 - 2009
N2 - In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway.
AB - In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515). RT-PCR analyses confirm the presence of MT2 transcripts in neural tissues and show MT2 expression in human pancreatic islets and beta cells. Our data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway.
U2 - 10.1038/ng.277
DO - 10.1038/ng.277
M3 - Journal article
C2 - 19060909
VL - 41
SP - 89
EP - 94
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 1
ER -
