Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses

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Association of the calpain-10 gene with type 2 diabetes in Europeans : results of pooled and meta-analyses. / Tsuchiya, Takafumi; Schwarz, Peter E H; Bosque-Plata, Laura Del; Geoffrey Hayes, M; Dina, Christian; Froguel, Philippe; Wayne Towers, G; Fischer, Sabine; Temelkova-Kurktschiev, Theodora; Rietzsch, Hannes; Graessler, Juergen; Vcelák, Josef; Palyzová, Daniela; Selisko, Thomas; Bendlová, Bela; Schulze, Jan; Julius, Ulrich; Hanefeld, Markolf; Weedon, Michael N; Evans, Julie C; Frayling, Timothy M; Hattersley, Andrew T; Orho-Melander, Marju; Groop, Leif; Malecki, Maciej T; Hansen, Torben; Pedersen, Oluf; Fingerlin, Tasha E; Boehnke, Michael; Hanis, Craig L; Cox, Nancy J; Bell, Graeme I.

In: Molecular Genetics and Metabolism, Vol. 89, No. 1-2, 2006, p. 174-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tsuchiya, T, Schwarz, PEH, Bosque-Plata, LD, Geoffrey Hayes, M, Dina, C, Froguel, P, Wayne Towers, G, Fischer, S, Temelkova-Kurktschiev, T, Rietzsch, H, Graessler, J, Vcelák, J, Palyzová, D, Selisko, T, Bendlová, B, Schulze, J, Julius, U, Hanefeld, M, Weedon, MN, Evans, JC, Frayling, TM, Hattersley, AT, Orho-Melander, M, Groop, L, Malecki, MT, Hansen, T, Pedersen, O, Fingerlin, TE, Boehnke, M, Hanis, CL, Cox, NJ & Bell, GI 2006, 'Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses', Molecular Genetics and Metabolism, vol. 89, no. 1-2, pp. 174-84. https://doi.org/10.1016/j.ymgme.2006.05.013

APA

Tsuchiya, T., Schwarz, P. E. H., Bosque-Plata, L. D., Geoffrey Hayes, M., Dina, C., Froguel, P., Wayne Towers, G., Fischer, S., Temelkova-Kurktschiev, T., Rietzsch, H., Graessler, J., Vcelák, J., Palyzová, D., Selisko, T., Bendlová, B., Schulze, J., Julius, U., Hanefeld, M., Weedon, M. N., ... Bell, G. I. (2006). Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Molecular Genetics and Metabolism, 89(1-2), 174-84. https://doi.org/10.1016/j.ymgme.2006.05.013

Vancouver

Tsuchiya T, Schwarz PEH, Bosque-Plata LD, Geoffrey Hayes M, Dina C, Froguel P et al. Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Molecular Genetics and Metabolism. 2006;89(1-2):174-84. https://doi.org/10.1016/j.ymgme.2006.05.013

Author

Tsuchiya, Takafumi ; Schwarz, Peter E H ; Bosque-Plata, Laura Del ; Geoffrey Hayes, M ; Dina, Christian ; Froguel, Philippe ; Wayne Towers, G ; Fischer, Sabine ; Temelkova-Kurktschiev, Theodora ; Rietzsch, Hannes ; Graessler, Juergen ; Vcelák, Josef ; Palyzová, Daniela ; Selisko, Thomas ; Bendlová, Bela ; Schulze, Jan ; Julius, Ulrich ; Hanefeld, Markolf ; Weedon, Michael N ; Evans, Julie C ; Frayling, Timothy M ; Hattersley, Andrew T ; Orho-Melander, Marju ; Groop, Leif ; Malecki, Maciej T ; Hansen, Torben ; Pedersen, Oluf ; Fingerlin, Tasha E ; Boehnke, Michael ; Hanis, Craig L ; Cox, Nancy J ; Bell, Graeme I. / Association of the calpain-10 gene with type 2 diabetes in Europeans : results of pooled and meta-analyses. In: Molecular Genetics and Metabolism. 2006 ; Vol. 89, No. 1-2. pp. 174-84.

Bibtex

@article{e092c52421c04074827593abedaa993a,
title = "Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses",
abstract = "We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR)=1.11 (95% confidence interval (CI), 1.02-1.20), P=0.01). Two haplotype combinations were associated with increased risk of T2D (1-2-1/1-2-1, OR=1.20 (1.03-1.41), P=0.02; and 1-1-2/1-2-1, OR=1.26 (1.01-1.59), P=0.04) and one with decreased risk (1-1-1/2-2-1, OR=0.86 (0.75-0.99), P=0.03). The meta-analysis also showed a significant effect of the 1-2-1/1-2-1 haplogenotype on risk (OR=1.25 (1.05-1.50), P=0.01). However, there was evidence for heterogeneity with respect to this effect (P=0.06). The heterogeneity appeared to be due to data sets in which the cases were selected from samples used in linkage studies of T2D. Using only the population-based case-control samples removed the heterogeneity (P=0.89) and strengthened the evidence for association with T2D in both the pooled (SNP-43*G, OR=1.19 (1.07-1.32), P=0.001; 1-2-1/1-2-1 haplogenotype, OR=1.46 (1.19-1.78), P=0.0003; 1-1-2/1-2-1 haplogenotype, OR=1.52 (1.12-2.06), P=0.007; and 1-1-1/2-2-1 haplogenotype, OR=0.83 (0.70-0.99), P=0.03) and the meta-analysis (SNP-43*G, OR=1.18 (1.05-1.32), P=0.005; 1-2-1/1-2-1 haplogenotype, OR=1.68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans.",
keywords = "Calpain, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide",
author = "Takafumi Tsuchiya and Schwarz, {Peter E H} and Bosque-Plata, {Laura Del} and {Geoffrey Hayes}, M and Christian Dina and Philippe Froguel and {Wayne Towers}, G and Sabine Fischer and Theodora Temelkova-Kurktschiev and Hannes Rietzsch and Juergen Graessler and Josef Vcel{\'a}k and Daniela Palyzov{\'a} and Thomas Selisko and Bela Bendlov{\'a} and Jan Schulze and Ulrich Julius and Markolf Hanefeld and Weedon, {Michael N} and Evans, {Julie C} and Frayling, {Timothy M} and Hattersley, {Andrew T} and Marju Orho-Melander and Leif Groop and Malecki, {Maciej T} and Torben Hansen and Oluf Pedersen and Fingerlin, {Tasha E} and Michael Boehnke and Hanis, {Craig L} and Cox, {Nancy J} and Bell, {Graeme I}",
year = "2006",
doi = "10.1016/j.ymgme.2006.05.013",
language = "English",
volume = "89",
pages = "174--84",
journal = "Molecular Genetics and Metabolism",
issn = "1096-7192",
publisher = "Academic Press",
number = "1-2",

}

RIS

TY - JOUR

T1 - Association of the calpain-10 gene with type 2 diabetes in Europeans

T2 - results of pooled and meta-analyses

AU - Tsuchiya, Takafumi

AU - Schwarz, Peter E H

AU - Bosque-Plata, Laura Del

AU - Geoffrey Hayes, M

AU - Dina, Christian

AU - Froguel, Philippe

AU - Wayne Towers, G

AU - Fischer, Sabine

AU - Temelkova-Kurktschiev, Theodora

AU - Rietzsch, Hannes

AU - Graessler, Juergen

AU - Vcelák, Josef

AU - Palyzová, Daniela

AU - Selisko, Thomas

AU - Bendlová, Bela

AU - Schulze, Jan

AU - Julius, Ulrich

AU - Hanefeld, Markolf

AU - Weedon, Michael N

AU - Evans, Julie C

AU - Frayling, Timothy M

AU - Hattersley, Andrew T

AU - Orho-Melander, Marju

AU - Groop, Leif

AU - Malecki, Maciej T

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Fingerlin, Tasha E

AU - Boehnke, Michael

AU - Hanis, Craig L

AU - Cox, Nancy J

AU - Bell, Graeme I

PY - 2006

Y1 - 2006

N2 - We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR)=1.11 (95% confidence interval (CI), 1.02-1.20), P=0.01). Two haplotype combinations were associated with increased risk of T2D (1-2-1/1-2-1, OR=1.20 (1.03-1.41), P=0.02; and 1-1-2/1-2-1, OR=1.26 (1.01-1.59), P=0.04) and one with decreased risk (1-1-1/2-2-1, OR=0.86 (0.75-0.99), P=0.03). The meta-analysis also showed a significant effect of the 1-2-1/1-2-1 haplogenotype on risk (OR=1.25 (1.05-1.50), P=0.01). However, there was evidence for heterogeneity with respect to this effect (P=0.06). The heterogeneity appeared to be due to data sets in which the cases were selected from samples used in linkage studies of T2D. Using only the population-based case-control samples removed the heterogeneity (P=0.89) and strengthened the evidence for association with T2D in both the pooled (SNP-43*G, OR=1.19 (1.07-1.32), P=0.001; 1-2-1/1-2-1 haplogenotype, OR=1.46 (1.19-1.78), P=0.0003; 1-1-2/1-2-1 haplogenotype, OR=1.52 (1.12-2.06), P=0.007; and 1-1-1/2-2-1 haplogenotype, OR=0.83 (0.70-0.99), P=0.03) and the meta-analysis (SNP-43*G, OR=1.18 (1.05-1.32), P=0.005; 1-2-1/1-2-1 haplogenotype, OR=1.68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans.

AB - We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR)=1.11 (95% confidence interval (CI), 1.02-1.20), P=0.01). Two haplotype combinations were associated with increased risk of T2D (1-2-1/1-2-1, OR=1.20 (1.03-1.41), P=0.02; and 1-1-2/1-2-1, OR=1.26 (1.01-1.59), P=0.04) and one with decreased risk (1-1-1/2-2-1, OR=0.86 (0.75-0.99), P=0.03). The meta-analysis also showed a significant effect of the 1-2-1/1-2-1 haplogenotype on risk (OR=1.25 (1.05-1.50), P=0.01). However, there was evidence for heterogeneity with respect to this effect (P=0.06). The heterogeneity appeared to be due to data sets in which the cases were selected from samples used in linkage studies of T2D. Using only the population-based case-control samples removed the heterogeneity (P=0.89) and strengthened the evidence for association with T2D in both the pooled (SNP-43*G, OR=1.19 (1.07-1.32), P=0.001; 1-2-1/1-2-1 haplogenotype, OR=1.46 (1.19-1.78), P=0.0003; 1-1-2/1-2-1 haplogenotype, OR=1.52 (1.12-2.06), P=0.007; and 1-1-1/2-2-1 haplogenotype, OR=0.83 (0.70-0.99), P=0.03) and the meta-analysis (SNP-43*G, OR=1.18 (1.05-1.32), P=0.005; 1-2-1/1-2-1 haplogenotype, OR=1.68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans.

KW - Calpain

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Haplotypes

KW - Humans

KW - Linkage Disequilibrium

KW - Polymorphism, Single Nucleotide

U2 - 10.1016/j.ymgme.2006.05.013

DO - 10.1016/j.ymgme.2006.05.013

M3 - Journal article

C2 - 16837224

VL - 89

SP - 174

EP - 184

JO - Molecular Genetics and Metabolism

JF - Molecular Genetics and Metabolism

SN - 1096-7192

IS - 1-2

ER -

ID: 38455353