Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics from birth through age 7 y assessed in the Danish National Birth Cohort
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Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics from birth through age 7 y assessed in the Danish National Birth Cohort. / Sorensen, Thorkild I. A.; Ajslev, Teresa Adeltoft; Angquist, Lars; Morgen, Camilla Schmidt; Ciuchi, Ioana Gabriela; Smith, George Davey.
In: The American Journal of Clinical Nutrition, Vol. 104, No. 2, 01.08.2016, p. 389-396.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics from birth through age 7 y assessed in the Danish National Birth Cohort
AU - Sorensen, Thorkild I. A.
AU - Ajslev, Teresa Adeltoft
AU - Angquist, Lars
AU - Morgen, Camilla Schmidt
AU - Ciuchi, Ioana Gabriela
AU - Smith, George Davey
PY - 2016/8/1
Y1 - 2016/8/1
N2 - ABSTRACTBackground: Maternal prepregnancy adiposity may influence childadiposity beyond the transmitted genetic effects, which, if true, mayaccelerate the obesity epidemic, but the evidence for this mechanismis inconsistent.Objective: The aim was to assess whether the associations of maternalbody mass index (BMI) with child anthropometric measurements from birththrough infancy and at 7 y of age exceed those of paternal associations.Design: In the Danish National Birth Cohort, information on parentaland child anthropometric measures is available for 30,655 triofamilies from maternal interviews during pregnancy and the postpartumperiod and from a 7-y follow-up. By using multiple linearand logistic regression models of child SD (z) scores of weight andBMI at birth, 5 mo, 12 mo, and 7 y of age, and of child overweight atage 7 y, we compared associations with maternal prepregnancy andpostpartum BMI z scores and with paternal BMI z scores.Results: When comparing maternal-child and paternal-child BMI zscore associations, the strongest associations were observed withmothers’ BMI at birth [maternal and paternal BMI z scores: 0.143(95% CI: 0.130, 0.155) and 0.017 (95% CI: 0.005, 0.029), respectively]and throughout infancy, but the relative difference in the associationsdeclined by child age [for BMI z score at child age 7 y per maternaland paternal BMI z scores: 0.208 (95% CI: 0.196, 0.220) and 0.154(95% CI: 0.143, 0.166), respectively]. At 7 y of age, ORs of childoverweight were 2.30 (95% CI: 1.99, 2.67) by maternal overweightand 1.96 (95% CI: 1.74, 2.21) by paternal overweight. There were nodifferences between the results based on maternal BMI before andafter pregnancy or on child’s weight adjusted for length or height.Conclusions: The associations of child weight and BMI with maternalBMI were stronger than with paternal BMI. The differencesbetween the associations were strong at birth but declined with childaging.
AB - ABSTRACTBackground: Maternal prepregnancy adiposity may influence childadiposity beyond the transmitted genetic effects, which, if true, mayaccelerate the obesity epidemic, but the evidence for this mechanismis inconsistent.Objective: The aim was to assess whether the associations of maternalbody mass index (BMI) with child anthropometric measurements from birththrough infancy and at 7 y of age exceed those of paternal associations.Design: In the Danish National Birth Cohort, information on parentaland child anthropometric measures is available for 30,655 triofamilies from maternal interviews during pregnancy and the postpartumperiod and from a 7-y follow-up. By using multiple linearand logistic regression models of child SD (z) scores of weight andBMI at birth, 5 mo, 12 mo, and 7 y of age, and of child overweight atage 7 y, we compared associations with maternal prepregnancy andpostpartum BMI z scores and with paternal BMI z scores.Results: When comparing maternal-child and paternal-child BMI zscore associations, the strongest associations were observed withmothers’ BMI at birth [maternal and paternal BMI z scores: 0.143(95% CI: 0.130, 0.155) and 0.017 (95% CI: 0.005, 0.029), respectively]and throughout infancy, but the relative difference in the associationsdeclined by child age [for BMI z score at child age 7 y per maternaland paternal BMI z scores: 0.208 (95% CI: 0.196, 0.220) and 0.154(95% CI: 0.143, 0.166), respectively]. At 7 y of age, ORs of childoverweight were 2.30 (95% CI: 1.99, 2.67) by maternal overweightand 1.96 (95% CI: 1.74, 2.21) by paternal overweight. There were nodifferences between the results based on maternal BMI before andafter pregnancy or on child’s weight adjusted for length or height.Conclusions: The associations of child weight and BMI with maternalBMI were stronger than with paternal BMI. The differencesbetween the associations were strong at birth but declined with childaging.
KW - intrauterine environment
KW - intergenerational relations
KW - parental BMI
KW - parental overweight
KW - child anthropometry
KW - childhood overweight
KW - maternal effects
U2 - 10.3945/ajcn.115.129171
DO - 10.3945/ajcn.115.129171
M3 - Journal article
C2 - 27413126
VL - 104
SP - 389
EP - 396
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 2
ER -
ID: 165744026