TY - JOUR

T1 - Genetic and familial environmental effects on suicide attempts

T2 - A study of Danish adoptees and their biological and adoptive siblings

AU - Petersen, Liselotte

AU - Sørensen, Thorkild I A

AU - Andersen, Per Kragh

AU - Mortensen, Preben Bo

AU - Hawton, Keith

N1 - © 2013 Published by Elsevier B.V.

PY - 2014/2

Y1 - 2014/2

N2 - OBJECTIVES: Genetic factors have been found to influence the risk of suicide. It is less clear if this also applies to attempted suicide. We have investigated genetic and familial environmental factors by studying the occurrence of suicide attempts in biological and adoptive siblings of adoptees who attempted suicide compared to siblings of adoptees with no suicide attempts.METHOD: We used a random sample of 1933 adoptees from the Danish Adoption Register, a register of non-familial adoptions of Danish children, i.e. the adoptive parents are biologically unrelated to the adoptee. Analyses were conducted on incidence rates of attempted suicide in biological and adoptive siblings given occurrence of attempted suicide in the adoptees while also taking into account psychiatric disorders. Information about suicidal attempt and history of psychiatric disorder was based on hospital admissions.RESULTS: The rate of attempted suicide in full siblings of adoptees who attempted suicide before age 60 years was higher than in full siblings of adoptees who had not attempted suicide (incidence rate ratios (IRR)=3.45; 95% confidence interval [CI]=0.94-12.7). After adjustment for history of psychiatric admission of siblings the increased rate was statistically significant (IRR=3.88; 95% CI-1.42-10.6).LIMITATIONS: Information on attempted suicide and psychiatric history was limited to that which involved hospitalisation.CONCLUSIONS: Genetic factors influence risk of suicide attempts.

AB - OBJECTIVES: Genetic factors have been found to influence the risk of suicide. It is less clear if this also applies to attempted suicide. We have investigated genetic and familial environmental factors by studying the occurrence of suicide attempts in biological and adoptive siblings of adoptees who attempted suicide compared to siblings of adoptees with no suicide attempts.METHOD: We used a random sample of 1933 adoptees from the Danish Adoption Register, a register of non-familial adoptions of Danish children, i.e. the adoptive parents are biologically unrelated to the adoptee. Analyses were conducted on incidence rates of attempted suicide in biological and adoptive siblings given occurrence of attempted suicide in the adoptees while also taking into account psychiatric disorders. Information about suicidal attempt and history of psychiatric disorder was based on hospital admissions.RESULTS: The rate of attempted suicide in full siblings of adoptees who attempted suicide before age 60 years was higher than in full siblings of adoptees who had not attempted suicide (incidence rate ratios (IRR)=3.45; 95% confidence interval [CI]=0.94-12.7). After adjustment for history of psychiatric admission of siblings the increased rate was statistically significant (IRR=3.88; 95% CI-1.42-10.6).LIMITATIONS: Information on attempted suicide and psychiatric history was limited to that which involved hospitalisation.CONCLUSIONS: Genetic factors influence risk of suicide attempts.

KW - Adoption

KW - Child

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Gene-Environment Interaction

KW - Humans

KW - Male

KW - Middle Aged

KW - Registries

KW - Risk Factors

KW - Siblings

KW - Suicide, Attempted

U2 - 10.1016/j.jad.2013.11.012

DO - 10.1016/j.jad.2013.11.012

M3 - Journal article

C2 - 24300827

VL - 155

SP - 273

EP - 277

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -