Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians

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Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. / Linneberg, A; Gonzalez-Quintela, A; Vidal, C; Jørgensen, Torben; Fenger, M; Hansen, T; Pedersen, Oluf; Husemoen, L L N.

In: Clinical and Experimental Allergy, Vol. 40, No. 1, 01.01.2010, p. 123-30.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Linneberg, A, Gonzalez-Quintela, A, Vidal, C, Jørgensen, T, Fenger, M, Hansen, T, Pedersen, O & Husemoen, LLN 2010, 'Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians', Clinical and Experimental Allergy, vol. 40, no. 1, pp. 123-30. https://doi.org/10.1111/j.1365-2222.2009.03398.x

APA

Linneberg, A., Gonzalez-Quintela, A., Vidal, C., Jørgensen, T., Fenger, M., Hansen, T., Pedersen, O., & Husemoen, L. L. N. (2010). Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. Clinical and Experimental Allergy, 40(1), 123-30. https://doi.org/10.1111/j.1365-2222.2009.03398.x

Vancouver

Linneberg A, Gonzalez-Quintela A, Vidal C, Jørgensen T, Fenger M, Hansen T et al. Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. Clinical and Experimental Allergy. 2010 Jan 1;40(1):123-30. https://doi.org/10.1111/j.1365-2222.2009.03398.x

Author

Linneberg, A ; Gonzalez-Quintela, A ; Vidal, C ; Jørgensen, Torben ; Fenger, M ; Hansen, T ; Pedersen, Oluf ; Husemoen, L L N. / Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. In: Clinical and Experimental Allergy. 2010 ; Vol. 40, No. 1. pp. 123-30.

Bibtex

@article{6a5b050e5e504092a92dc9ca8ba4f502,
title = "Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians",
abstract = "Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.",
keywords = "Acetaldehyde, Adolescent, Adult, Aged, Alcoholic Beverages, Alcoholism, Aldehyde Dehydrogenase, Alleles, Denmark, Drug Hypersensitivity, Ethanol, European Continental Ancestry Group, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged",
author = "A Linneberg and A Gonzalez-Quintela and C Vidal and Torben J{\o}rgensen and M Fenger and T Hansen and Oluf Pedersen and Husemoen, {L L N}",
year = "2010",
month = jan,
day = "1",
doi = "10.1111/j.1365-2222.2009.03398.x",
language = "English",
volume = "40",
pages = "123--30",
journal = "Clinical Allergy",
issn = "0954-7894",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians

AU - Linneberg, A

AU - Gonzalez-Quintela, A

AU - Vidal, C

AU - Jørgensen, Torben

AU - Fenger, M

AU - Hansen, T

AU - Pedersen, Oluf

AU - Husemoen, L L N

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.

AB - Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.

KW - Acetaldehyde

KW - Adolescent

KW - Adult

KW - Aged

KW - Alcoholic Beverages

KW - Alcoholism

KW - Aldehyde Dehydrogenase

KW - Alleles

KW - Denmark

KW - Drug Hypersensitivity

KW - Ethanol

KW - European Continental Ancestry Group

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Middle Aged

U2 - 10.1111/j.1365-2222.2009.03398.x

DO - 10.1111/j.1365-2222.2009.03398.x

M3 - Journal article

C2 - 20205700

VL - 40

SP - 123

EP - 130

JO - Clinical Allergy

JF - Clinical Allergy

SN - 0954-7894

IS - 1

ER -

ID: 33505572