Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians
Research output: Contribution to journal › Journal article › Research › peer-review
Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.
| Original language | English |
|---|---|
| Journal | Clinical and Experimental Allergy |
| Volume | 40 |
| Issue number | 1 |
| Pages (from-to) | 123-30 |
| Number of pages | 8 |
| ISSN | 0954-7894 |
| DOIs | |
| Publication status | Published - 1 Jan 2010 |
- Acetaldehyde, Adolescent, Adult, Aged, Alcoholic Beverages, Alcoholism, Aldehyde Dehydrogenase, Alleles, Denmark, Drug Hypersensitivity, Ethanol, European Continental Ancestry Group, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged
Research areas
ID: 33505572