Increasing genetic variance of body mass index during the Swedish obesity epidemic
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Increasing genetic variance of body mass index during the Swedish obesity epidemic. / Rokholm, Benjamin; Silventoinen, Karri; Tynelius, Per; Gamborg, Michael; Sørensen, Thorkild I A; Rasmussen, Finn.
In: P L o S One, Vol. 6, No. 11, 2011, p. e27135.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increasing genetic variance of body mass index during the Swedish obesity epidemic
AU - Rokholm, Benjamin
AU - Silventoinen, Karri
AU - Tynelius, Per
AU - Gamborg, Michael
AU - Sørensen, Thorkild I A
AU - Rasmussen, Finn
PY - 2011
Y1 - 2011
N2 - There is no doubt that the dramatic worldwide increase in obesity prevalence is due to changes in environmental factors. However, twin and family studies suggest that genetic differences are responsible for the major part of the variation in adiposity within populations. Recent studies show that the genetic effects on body mass index (BMI) may be stronger when combined with presumed risk factors for obesity. We tested the hypothesis that the genetic variance of BMI has increased during the obesity epidemic.
AB - There is no doubt that the dramatic worldwide increase in obesity prevalence is due to changes in environmental factors. However, twin and family studies suggest that genetic differences are responsible for the major part of the variation in adiposity within populations. Recent studies show that the genetic effects on body mass index (BMI) may be stronger when combined with presumed risk factors for obesity. We tested the hypothesis that the genetic variance of BMI has increased during the obesity epidemic.
U2 - 10.1371/journal.pone.0027135
DO - 10.1371/journal.pone.0027135
M3 - Journal article
C2 - 22087252
VL - 6
SP - e27135
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
ER -
ID: 40207818