Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity

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Standard

Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity. / Lund, Morten A.; Thostrup, Anne H.; Frithioff-Bojsoe, Christine; Lausten-Thomsen, Ulrik; Hedley, Paula L.; Pedersen, Oluf; Christiansen, Michael; Hansen, Torben; Holm, Jens-Christian.

In: Nutrition, Metabolism & Cardiovascular Diseases, Vol. 30, No. 9, 2020, p. 1544-1553.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lund, MA, Thostrup, AH, Frithioff-Bojsoe, C, Lausten-Thomsen, U, Hedley, PL, Pedersen, O, Christiansen, M, Hansen, T & Holm, J-C 2020, 'Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity', Nutrition, Metabolism & Cardiovascular Diseases, vol. 30, no. 9, pp. 1544-1553. https://doi.org/10.1016/j.numecd.2020.04.024

APA

Lund, M. A., Thostrup, A. H., Frithioff-Bojsoe, C., Lausten-Thomsen, U., Hedley, P. L., Pedersen, O., Christiansen, M., Hansen, T., & Holm, J-C. (2020). Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity. Nutrition, Metabolism & Cardiovascular Diseases, 30(9), 1544-1553. https://doi.org/10.1016/j.numecd.2020.04.024

Vancouver

Lund MA, Thostrup AH, Frithioff-Bojsoe C, Lausten-Thomsen U, Hedley PL, Pedersen O et al. Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity. Nutrition, Metabolism & Cardiovascular Diseases. 2020;30(9):1544-1553. https://doi.org/10.1016/j.numecd.2020.04.024

Author

Lund, Morten A. ; Thostrup, Anne H. ; Frithioff-Bojsoe, Christine ; Lausten-Thomsen, Ulrik ; Hedley, Paula L. ; Pedersen, Oluf ; Christiansen, Michael ; Hansen, Torben ; Holm, Jens-Christian. / Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity. In: Nutrition, Metabolism & Cardiovascular Diseases. 2020 ; Vol. 30, No. 9. pp. 1544-1553.

Bibtex

@article{25c300f88ffe4bc7914535963989c394,
title = "Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity",
abstract = "Background and aims: Pediatric obesity associates with both low-grade inflammation and cardiometabolic risk on the population level. Yet on an individual patient level, overweight/obesity does not always equal increased cardiometabolic risk. In this study, we examine whether low-grade inflammation associates with cardiometabolic risk in Danish children, independent of degree of adiposity. We further assess the value of integrating multiple inflammation markers to identify children with very-high cardiometabolic risk profiles.Method and results: We studied 2192 children and adolescents aged 6-18 years from an obesity clinic cohort and a population-based cohort, in a cross-sectional study design. Anthropometry, blood pressure, pubertal stage and body composition by dual-energy X-ray absorptiometry were assessed, and biomarkers including fasting serum high sensitivity C-reactive protein (hsCRP), white blood cells (WBC), resistin, lipid profile and glucose metabolism were measured. Adjusted correlation analysis and odds ratios were calculated. We found that, independent of degree of adiposity, having high-normal inflammation marker concentrations associated with increased cardiometabolic risk: for girls, hsCRP >0.57-9.98 mg/L (mid/upper tertile) associated with similar to 2-fold higher odds of dyslipidemia and hepatic steatosis (vs. lower tertile). For both sexes, WBC >7.0-12.4 10(9) /L (upper tertile) associated with 2.5-fold higher odds of insulin resistance. Lastly, children with multiple inflammation markers in the high-normal range exhibited the most severe cardiometabolic risk profile.Conclusion: Low-grade inflammation associates with cardiometabolic risk in children independent of degree of adiposity. The associations vary with sex and inflammation marker measured. Finally, integrating multiple low-grade inflammation markers identifies a very-high-risk subgroup of children with overweight/obesity and may have clinical value. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.",
keywords = "Childhood obesity, Low-grade inflammation, Cardiometabolic risk, High-sensitivity C-reactive protein, White blood cells, Resistin, Dyslipidemia, Insulin resistance, C-REACTIVE PROTEIN, CARDIOVASCULAR RISK, REFERENCE VALUES, OBESE CHILDREN, SYSTEMIC INFLAMMATION, METABOLIC-SYNDROME, PUBERTAL CHANGES, SERUM RESISTIN, ADOLESCENTS, GUIDELINES",
author = "Lund, {Morten A.} and Thostrup, {Anne H.} and Christine Frithioff-Bojsoe and Ulrik Lausten-Thomsen and Hedley, {Paula L.} and Oluf Pedersen and Michael Christiansen and Torben Hansen and Jens-Christian Holm",
year = "2020",
doi = "10.1016/j.numecd.2020.04.024",
language = "English",
volume = "30",
pages = "1544--1553",
journal = "Nutrition, Metabolism & Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Low-grade inflammation independently associates with cardiometabolic risk in children with overweight/obesity

AU - Lund, Morten A.

AU - Thostrup, Anne H.

AU - Frithioff-Bojsoe, Christine

AU - Lausten-Thomsen, Ulrik

AU - Hedley, Paula L.

AU - Pedersen, Oluf

AU - Christiansen, Michael

AU - Hansen, Torben

AU - Holm, Jens-Christian

PY - 2020

Y1 - 2020

N2 - Background and aims: Pediatric obesity associates with both low-grade inflammation and cardiometabolic risk on the population level. Yet on an individual patient level, overweight/obesity does not always equal increased cardiometabolic risk. In this study, we examine whether low-grade inflammation associates with cardiometabolic risk in Danish children, independent of degree of adiposity. We further assess the value of integrating multiple inflammation markers to identify children with very-high cardiometabolic risk profiles.Method and results: We studied 2192 children and adolescents aged 6-18 years from an obesity clinic cohort and a population-based cohort, in a cross-sectional study design. Anthropometry, blood pressure, pubertal stage and body composition by dual-energy X-ray absorptiometry were assessed, and biomarkers including fasting serum high sensitivity C-reactive protein (hsCRP), white blood cells (WBC), resistin, lipid profile and glucose metabolism were measured. Adjusted correlation analysis and odds ratios were calculated. We found that, independent of degree of adiposity, having high-normal inflammation marker concentrations associated with increased cardiometabolic risk: for girls, hsCRP >0.57-9.98 mg/L (mid/upper tertile) associated with similar to 2-fold higher odds of dyslipidemia and hepatic steatosis (vs. lower tertile). For both sexes, WBC >7.0-12.4 10(9) /L (upper tertile) associated with 2.5-fold higher odds of insulin resistance. Lastly, children with multiple inflammation markers in the high-normal range exhibited the most severe cardiometabolic risk profile.Conclusion: Low-grade inflammation associates with cardiometabolic risk in children independent of degree of adiposity. The associations vary with sex and inflammation marker measured. Finally, integrating multiple low-grade inflammation markers identifies a very-high-risk subgroup of children with overweight/obesity and may have clinical value. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

AB - Background and aims: Pediatric obesity associates with both low-grade inflammation and cardiometabolic risk on the population level. Yet on an individual patient level, overweight/obesity does not always equal increased cardiometabolic risk. In this study, we examine whether low-grade inflammation associates with cardiometabolic risk in Danish children, independent of degree of adiposity. We further assess the value of integrating multiple inflammation markers to identify children with very-high cardiometabolic risk profiles.Method and results: We studied 2192 children and adolescents aged 6-18 years from an obesity clinic cohort and a population-based cohort, in a cross-sectional study design. Anthropometry, blood pressure, pubertal stage and body composition by dual-energy X-ray absorptiometry were assessed, and biomarkers including fasting serum high sensitivity C-reactive protein (hsCRP), white blood cells (WBC), resistin, lipid profile and glucose metabolism were measured. Adjusted correlation analysis and odds ratios were calculated. We found that, independent of degree of adiposity, having high-normal inflammation marker concentrations associated with increased cardiometabolic risk: for girls, hsCRP >0.57-9.98 mg/L (mid/upper tertile) associated with similar to 2-fold higher odds of dyslipidemia and hepatic steatosis (vs. lower tertile). For both sexes, WBC >7.0-12.4 10(9) /L (upper tertile) associated with 2.5-fold higher odds of insulin resistance. Lastly, children with multiple inflammation markers in the high-normal range exhibited the most severe cardiometabolic risk profile.Conclusion: Low-grade inflammation associates with cardiometabolic risk in children independent of degree of adiposity. The associations vary with sex and inflammation marker measured. Finally, integrating multiple low-grade inflammation markers identifies a very-high-risk subgroup of children with overweight/obesity and may have clinical value. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

KW - Childhood obesity

KW - Low-grade inflammation

KW - Cardiometabolic risk

KW - High-sensitivity C-reactive protein

KW - White blood cells

KW - Resistin

KW - Dyslipidemia

KW - Insulin resistance

KW - C-REACTIVE PROTEIN

KW - CARDIOVASCULAR RISK

KW - REFERENCE VALUES

KW - OBESE CHILDREN

KW - SYSTEMIC INFLAMMATION

KW - METABOLIC-SYNDROME

KW - PUBERTAL CHANGES

KW - SERUM RESISTIN

KW - ADOLESCENTS

KW - GUIDELINES

U2 - 10.1016/j.numecd.2020.04.024

DO - 10.1016/j.numecd.2020.04.024

M3 - Journal article

C2 - 32571613

VL - 30

SP - 1544

EP - 1553

JO - Nutrition, Metabolism & Cardiovascular Diseases

JF - Nutrition, Metabolism & Cardiovascular Diseases

SN - 0939-4753

IS - 9

ER -

ID: 248332534