New Insights into the Genetics of Latent Autoimmune Diabetes in Adults

Research output: Contribution to journal › Review › Research › peer-review

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New Insights into the Genetics of Latent Autoimmune Diabetes in Adults. / Andersen, Mette K.

In: Current Diabetes Reports, Vol. 20, 43, 2020.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Andersen, MK 2020, 'New Insights into the Genetics of Latent Autoimmune Diabetes in Adults', Current Diabetes Reports, vol. 20, 43. https://doi.org/10.1007/s11892-020-01330-y

APA

Andersen, M. K. (2020). New Insights into the Genetics of Latent Autoimmune Diabetes in Adults. Current Diabetes Reports, 20, [43]. https://doi.org/10.1007/s11892-020-01330-y

Vancouver

Andersen MK. New Insights into the Genetics of Latent Autoimmune Diabetes in Adults. Current Diabetes Reports. 2020;20. 43. https://doi.org/10.1007/s11892-020-01330-y

Author

Andersen, Mette K. / New Insights into the Genetics of Latent Autoimmune Diabetes in Adults. In: Current Diabetes Reports. 2020 ; Vol. 20.

Bibtex

@article{d681be876ab545b5a6818c7d36bb95f4,
title = "New Insights into the Genetics of Latent Autoimmune Diabetes in Adults",
abstract = "Purpose of Review Diabetes is a spectrum of clinical manifestations, including latent autoimmune diabetes in adults (LADA). However, it has been questioned whether LADA exists or simply is a group of misclassified type 1 diabetes (T1D) and type 2 diabetes (T2D) patients. This review will provide an updated overview of the genetics of LADA, highlight what genetics tell us about LADA as a diabetes subtype, and point to future directions in the study of LADA. Recent Findings Recent studies have verified the genetic overlap between LADA and both T1D and T2D and have contributed identification of a novel LADA-specific locus, namely,PFKFB3, and subtype-specific signatures in the HLA region. Genetic risk scores comprising T1D-risk variants have been shown to be a promising tool for discriminating diabetes subtypes and identifying patients rapidly progressing to insulin dependence. Genetic data support the existence of LADA, but further studies are needed to fully determine the place of LADA in the diabetes spectrum.",
keywords = "LADA, Latent autoimmune diabetes in adults, HLA, PFKFB3, Genetic risk score, SINGLE NUCLEOTIDE POLYMORPHISMS, BETA-CELL FRAGILITY, HL-A ANTIGENS, INSULIN GENE, INDUCIBLE 6-PHOSPHOFRUCTO-2-KINASE, CLINICAL CHARACTERISTICS, SUSCEPTIBILITY LOCUS, HUMAN THYMUS, LADA CHINA, TYPE-1",
author = "Andersen, {Mette K.}",
year = "2020",
doi = "10.1007/s11892-020-01330-y",
language = "English",
volume = "20",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Springer Healthcare",

}

RIS

TY - JOUR

T1 - New Insights into the Genetics of Latent Autoimmune Diabetes in Adults

AU - Andersen, Mette K.

PY - 2020

Y1 - 2020

N2 - Purpose of Review Diabetes is a spectrum of clinical manifestations, including latent autoimmune diabetes in adults (LADA). However, it has been questioned whether LADA exists or simply is a group of misclassified type 1 diabetes (T1D) and type 2 diabetes (T2D) patients. This review will provide an updated overview of the genetics of LADA, highlight what genetics tell us about LADA as a diabetes subtype, and point to future directions in the study of LADA. Recent Findings Recent studies have verified the genetic overlap between LADA and both T1D and T2D and have contributed identification of a novel LADA-specific locus, namely,PFKFB3, and subtype-specific signatures in the HLA region. Genetic risk scores comprising T1D-risk variants have been shown to be a promising tool for discriminating diabetes subtypes and identifying patients rapidly progressing to insulin dependence. Genetic data support the existence of LADA, but further studies are needed to fully determine the place of LADA in the diabetes spectrum.

AB - Purpose of Review Diabetes is a spectrum of clinical manifestations, including latent autoimmune diabetes in adults (LADA). However, it has been questioned whether LADA exists or simply is a group of misclassified type 1 diabetes (T1D) and type 2 diabetes (T2D) patients. This review will provide an updated overview of the genetics of LADA, highlight what genetics tell us about LADA as a diabetes subtype, and point to future directions in the study of LADA. Recent Findings Recent studies have verified the genetic overlap between LADA and both T1D and T2D and have contributed identification of a novel LADA-specific locus, namely,PFKFB3, and subtype-specific signatures in the HLA region. Genetic risk scores comprising T1D-risk variants have been shown to be a promising tool for discriminating diabetes subtypes and identifying patients rapidly progressing to insulin dependence. Genetic data support the existence of LADA, but further studies are needed to fully determine the place of LADA in the diabetes spectrum.

KW - LADA

KW - Latent autoimmune diabetes in adults

KW - HLA

KW - PFKFB3

KW - Genetic risk score

KW - SINGLE NUCLEOTIDE POLYMORPHISMS

KW - BETA-CELL FRAGILITY

KW - HL-A ANTIGENS

KW - INSULIN GENE

KW - INDUCIBLE 6-PHOSPHOFRUCTO-2-KINASE

KW - CLINICAL CHARACTERISTICS

KW - SUSCEPTIBILITY LOCUS

KW - HUMAN THYMUS

KW - LADA CHINA

KW - TYPE-1

U2 - 10.1007/s11892-020-01330-y

DO - 10.1007/s11892-020-01330-y

M3 - Review

C2 - 32725517

VL - 20

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

M1 - 43

ER -

ID: 250121701