Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans : The NUGENOB Study. / Corpeleijn, Eva; Petersen, Liselotte; Holst, Claus; Saris, Wim H.; Astrup, Arne; Langin, Dominique; Macdonald, Ian; Martinez, J. Alfredo; Oppert, Jean-Michel; Polak, Jan; Pedersen, Oluf Borbye; Froguel, Philippe; Arner, Peter; Sørensen, Thorkild I.A.; Blaak, Ellen E.

In: Obesity, Vol. 18, No. 7, 2010, p. 1369-1377.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Corpeleijn, E, Petersen, L, Holst, C, Saris, WH, Astrup, A, Langin, D, Macdonald, I, Martinez, JA, Oppert, J-M, Polak, J, Pedersen, OB, Froguel, P, Arner, P, Sørensen, TIA & Blaak, EE 2010, 'Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study', Obesity, vol. 18, no. 7, pp. 1369-1377. https://doi.org/10.1038/oby.2009.377

APA

Corpeleijn, E., Petersen, L., Holst, C., Saris, W. H., Astrup, A., Langin, D., Macdonald, I., Martinez, J. A., Oppert, J-M., Polak, J., Pedersen, O. B., Froguel, P., Arner, P., Sørensen, T. I. A., & Blaak, E. E. (2010). Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study. Obesity, 18(7), 1369-1377. https://doi.org/10.1038/oby.2009.377

Vancouver

Corpeleijn E, Petersen L, Holst C, Saris WH, Astrup A, Langin D et al. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study. Obesity. 2010;18(7):1369-1377. https://doi.org/10.1038/oby.2009.377

Author

Corpeleijn, Eva ; Petersen, Liselotte ; Holst, Claus ; Saris, Wim H. ; Astrup, Arne ; Langin, Dominique ; Macdonald, Ian ; Martinez, J. Alfredo ; Oppert, Jean-Michel ; Polak, Jan ; Pedersen, Oluf Borbye ; Froguel, Philippe ; Arner, Peter ; Sørensen, Thorkild I.A. ; Blaak, Ellen E. / Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans : The NUGENOB Study. In: Obesity. 2010 ; Vol. 18, No. 7. pp. 1369-1377.

Bibtex

@article{ea123e5035ae11df8ed1000ea68e967b,
title = "Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans: The NUGENOB Study",
abstract = "Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.",
author = "Eva Corpeleijn and Liselotte Petersen and Claus Holst and Saris, {Wim H.} and Arne Astrup and Dominique Langin and Ian Macdonald and Martinez, {J. Alfredo} and Jean-Michel Oppert and Jan Polak and Pedersen, {Oluf Borbye} and Philippe Froguel and Peter Arner and S{\o}rensen, {Thorkild I.A.} and Blaak, {Ellen E.}",
year = "2010",
doi = "10.1038/oby.2009.377",
language = "English",
volume = "18",
pages = "1369--1377",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese europeans

T2 - The NUGENOB Study

AU - Corpeleijn, Eva

AU - Petersen, Liselotte

AU - Holst, Claus

AU - Saris, Wim H.

AU - Astrup, Arne

AU - Langin, Dominique

AU - Macdonald, Ian

AU - Martinez, J. Alfredo

AU - Oppert, Jean-Michel

AU - Polak, Jan

AU - Pedersen, Oluf Borbye

AU - Froguel, Philippe

AU - Arner, Peter

AU - Sørensen, Thorkild I.A.

AU - Blaak, Ellen E.

PY - 2010

Y1 - 2010

N2 - Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.

AB - Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.

U2 - 10.1038/oby.2009.377

DO - 10.1038/oby.2009.377

M3 - Journal article

C2 - 19876004

VL - 18

SP - 1369

EP - 1377

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 7

ER -

ID: 18765035