Physiology insights

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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Physiology insights. / Watanabe, Richard M; Hansen, Torben.

The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer, 2016. p. 207-221.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Watanabe, RM & Hansen, T 2016, Physiology insights. in The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer, pp. 207-221. https://doi.org/10.1007/978-3-319-01574-3_9

APA

Watanabe, R. M., & Hansen, T. (2016). Physiology insights. In The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation (pp. 207-221). Springer. https://doi.org/10.1007/978-3-319-01574-3_9

Vancouver

Watanabe RM, Hansen T. Physiology insights. In The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer. 2016. p. 207-221 https://doi.org/10.1007/978-3-319-01574-3_9

Author

Watanabe, Richard M ; Hansen, Torben. / Physiology insights. The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer, 2016. pp. 207-221

Bibtex

@inbook{b6d553c5c6da4502bb6dbd43e73f1ccd,
title = "Physiology insights",
abstract = "In recent years, the search for genetic determinants of type 2 diabetes has resulted in identification of numerous type 2 diabetes-associated loci as well as a number of loci associating with related prediabetic traits. These findings have illuminated new biological pathways contributing to the pathogenesis of type 2 diabetes, but have also demonstrated that type 2 diabetes is an extremely heterogeneous disease with limited overlap between genetic loci associating with type 2 diabetes and loci associating with diabetes-related traits, such as body mass index, fasting glucose levels, and fasting insulin levels. Combined, these loci only account for a fraction of the observed familial clustering of type 2 diabetes and only up to about 10 % of the variation in prediabetic quantitative traits. Improved methods are needed to dig deeper into a biological understanding of the pathophysiology of type 2 diabetes.",
author = "Watanabe, {Richard M} and Torben Hansen",
year = "2016",
doi = "10.1007/978-3-319-01574-3_9",
language = "English",
isbn = "978-3-319-01573-6",
pages = "207--221",
booktitle = "The Genetics of Type 2 Diabetes and Related Traits",
publisher = "Springer",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - Physiology insights

AU - Watanabe, Richard M

AU - Hansen, Torben

PY - 2016

Y1 - 2016

N2 - In recent years, the search for genetic determinants of type 2 diabetes has resulted in identification of numerous type 2 diabetes-associated loci as well as a number of loci associating with related prediabetic traits. These findings have illuminated new biological pathways contributing to the pathogenesis of type 2 diabetes, but have also demonstrated that type 2 diabetes is an extremely heterogeneous disease with limited overlap between genetic loci associating with type 2 diabetes and loci associating with diabetes-related traits, such as body mass index, fasting glucose levels, and fasting insulin levels. Combined, these loci only account for a fraction of the observed familial clustering of type 2 diabetes and only up to about 10 % of the variation in prediabetic quantitative traits. Improved methods are needed to dig deeper into a biological understanding of the pathophysiology of type 2 diabetes.

AB - In recent years, the search for genetic determinants of type 2 diabetes has resulted in identification of numerous type 2 diabetes-associated loci as well as a number of loci associating with related prediabetic traits. These findings have illuminated new biological pathways contributing to the pathogenesis of type 2 diabetes, but have also demonstrated that type 2 diabetes is an extremely heterogeneous disease with limited overlap between genetic loci associating with type 2 diabetes and loci associating with diabetes-related traits, such as body mass index, fasting glucose levels, and fasting insulin levels. Combined, these loci only account for a fraction of the observed familial clustering of type 2 diabetes and only up to about 10 % of the variation in prediabetic quantitative traits. Improved methods are needed to dig deeper into a biological understanding of the pathophysiology of type 2 diabetes.

U2 - 10.1007/978-3-319-01574-3_9

DO - 10.1007/978-3-319-01574-3_9

M3 - Book chapter

AN - SCOPUS:84978224441

SN - 978-3-319-01573-6

SP - 207

EP - 221

BT - The Genetics of Type 2 Diabetes and Related Traits

PB - Springer

ER -

ID: 179281986