Stability of the Associations between Early Life Risk Indicators and Adolescent Overweight over the Evolving Obesity Epidemic
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Stability of the Associations between Early Life Risk Indicators and Adolescent Overweight over the Evolving Obesity Epidemic. / Graversen, Lise; Sørensen, Thorkild I A; Petersen, Liselotte; Sovio, Ulla; Kaakinen, Marika; Sandbæk, Annelli; Laitinen, Jaana; Taanila, Anja; Pouta, Anneli; Järvelin, Marjo-Riitta; Obel, Carsten.
In: PLOS ONE, Vol. 9, No. 4, e95314, 2014, p. 1-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Stability of the Associations between Early Life Risk Indicators and Adolescent Overweight over the Evolving Obesity Epidemic
AU - Graversen, Lise
AU - Sørensen, Thorkild I A
AU - Petersen, Liselotte
AU - Sovio, Ulla
AU - Kaakinen, Marika
AU - Sandbæk, Annelli
AU - Laitinen, Jaana
AU - Taanila, Anja
AU - Pouta, Anneli
AU - Järvelin, Marjo-Riitta
AU - Obel, Carsten
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Pre- and perinatal factors and preschool body size may help identify children developing overweight, but these factors might have changed during the development of the obesity epidemic.OBJECTIVE: We aimed to assess the associations between early life risk indicators and overweight at the age of 9 and 15 years at different stages of the obesity epidemic.METHODS: We used two population-based Northern Finland Birth Cohorts including 4111 children born in 1966 (NFBC1966) and 5414 children born in 1985-1986 (NFBC1986). In both cohorts, we used the same a priori defined prenatal factors, maternal body mass index (BMI), birth weight, infant weight (age 5 months and 1 year), and preschool BMI (age 2-5 years). We used internal references in early childhood to define percentiles of body size (<50, 50-75, 75-90 and >90) and generalized linear models to study the association with overweight, according to the International Obesity Taskforce (IOTF) definitions, at the ages of 9 and 15 years.RESULTS: The prevalence of overweight at the age of 15 was 9% for children born in 1966 and 16% for children born in 1986. However, medians of infant weight and preschool BMI changed little between the cohorts, and we found similar associations between maternal BMI, infant weight, preschool BMI, and later overweight in the two cohorts. At 5 years, children above the 90th percentile had approximately a 12 times higher risk of being overweight at the age of 15 years compared to children below the 50th percentile in both cohorts.CONCLUSIONS: The associations between early body size and adolescent overweight showed remarkable stability, despite the increase in prevalence of overweight over the 20 years between the cohorts. Using consequently defined internal percentiles may be a valuable tool in clinical practice.
AB - BACKGROUND: Pre- and perinatal factors and preschool body size may help identify children developing overweight, but these factors might have changed during the development of the obesity epidemic.OBJECTIVE: We aimed to assess the associations between early life risk indicators and overweight at the age of 9 and 15 years at different stages of the obesity epidemic.METHODS: We used two population-based Northern Finland Birth Cohorts including 4111 children born in 1966 (NFBC1966) and 5414 children born in 1985-1986 (NFBC1986). In both cohorts, we used the same a priori defined prenatal factors, maternal body mass index (BMI), birth weight, infant weight (age 5 months and 1 year), and preschool BMI (age 2-5 years). We used internal references in early childhood to define percentiles of body size (<50, 50-75, 75-90 and >90) and generalized linear models to study the association with overweight, according to the International Obesity Taskforce (IOTF) definitions, at the ages of 9 and 15 years.RESULTS: The prevalence of overweight at the age of 15 was 9% for children born in 1966 and 16% for children born in 1986. However, medians of infant weight and preschool BMI changed little between the cohorts, and we found similar associations between maternal BMI, infant weight, preschool BMI, and later overweight in the two cohorts. At 5 years, children above the 90th percentile had approximately a 12 times higher risk of being overweight at the age of 15 years compared to children below the 50th percentile in both cohorts.CONCLUSIONS: The associations between early body size and adolescent overweight showed remarkable stability, despite the increase in prevalence of overweight over the 20 years between the cohorts. Using consequently defined internal percentiles may be a valuable tool in clinical practice.
KW - Adolescent
KW - Child
KW - Finland
KW - Humans
KW - Obesity
KW - Overweight
KW - Risk Factors
U2 - 10.1371/journal.pone.0095314
DO - 10.1371/journal.pone.0095314
M3 - Journal article
C2 - 24748033
VL - 9
SP - 1
EP - 9
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 4
M1 - e95314
ER -
ID: 138431709