Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice. / Sorensen, G.L.; Hjelmborg, J.V.B.; Leth-Larsen, R.; Schmidt, V.; Fenger, Mogens; Poulain, F.; Hawgood, S.; Sørensen, Thorkild I.A.; Kyvik, K.O.; Holmskov, U.

In: Scandinavian Journal of Immunology, Vol. 64, No. 6, 2006, p. 633-638.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sorensen, GL, Hjelmborg, JVB, Leth-Larsen, R, Schmidt, V, Fenger, M, Poulain, F, Hawgood, S, Sørensen, TIA, Kyvik, KO & Holmskov, U 2006, 'Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice', Scandinavian Journal of Immunology, vol. 64, no. 6, pp. 633-638. https://doi.org/10.1111/j.1365-3083.2006.01853.x, https://doi.org/10.1111/j.1365-3083.2006.01853.x

APA

Sorensen, G. L., Hjelmborg, J. V. B., Leth-Larsen, R., Schmidt, V., Fenger, M., Poulain, F., Hawgood, S., Sørensen, T. I. A., Kyvik, K. O., & Holmskov, U. (2006). Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice. Scandinavian Journal of Immunology, 64(6), 633-638. https://doi.org/10.1111/j.1365-3083.2006.01853.x, https://doi.org/10.1111/j.1365-3083.2006.01853.x

Vancouver

Sorensen GL, Hjelmborg JVB, Leth-Larsen R, Schmidt V, Fenger M, Poulain F et al. Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice. Scandinavian Journal of Immunology. 2006;64(6):633-638. https://doi.org/10.1111/j.1365-3083.2006.01853.x, https://doi.org/10.1111/j.1365-3083.2006.01853.x

Author

Sorensen, G.L. ; Hjelmborg, J.V.B. ; Leth-Larsen, R. ; Schmidt, V. ; Fenger, Mogens ; Poulain, F. ; Hawgood, S. ; Sørensen, Thorkild I.A. ; Kyvik, K.O. ; Holmskov, U. / Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice. In: Scandinavian Journal of Immunology. 2006 ; Vol. 64, No. 6. pp. 633-638.

Bibtex

@article{249883c070ec11dcbee902004c4f4f50,
title = "Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice",
abstract = "Surfactant protein D (SP-D) is a key regulator of pathogen-induced inflammation. SP-D is further involved in lipid homeostasis in mouse lung and circulation and recent data have demonstrated that the body mass index (BMI; in kg/m(2)) is influenced by genes in common with SP-D. The objective of the present study was to describe the association between serum SP-D and weight, waist circumference or BMI, and furthermore to observe body weight development in SP-D-deficient (Spd-/-) mice. As a part of the Danish population-based twin study (GEMINAKAR) on the metabolic syndrome, we analysed 1476 Danish twins for serum SP-D and investigated associations with weight, waist circumference and BMI by multiple regression analysis. Serum SP-D was significantly and inversely associated with weight (P = 0.001) and waist circumference in men (P < 0.001) and to BMI in both genders (P = 0.039 women, P < 0.001 men). The age-dependent increase in serum SP-D was most prominent in lean persons (BMI < 20). Spd-/- mice and wild-type mice were subjected to a feeding study and body weights were recorded in a time course over 24 weeks. Spd-/- mouse weight gain was significantly increased, with 90 mg/week (P < 0.0001) in males on normal chow. Fat percentage was significantly increased by 17% in the Spd-/- male mice (P = 0.003). We conclude, that there is an association between low levels or absent SP-D and obesity.",
author = "G.L. Sorensen and J.V.B. Hjelmborg and R. Leth-Larsen and V. Schmidt and Mogens Fenger and F. Poulain and S. Hawgood and S{\o}rensen, {Thorkild I.A.} and K.O. Kyvik and U. Holmskov",
year = "2006",
doi = "10.1111/j.1365-3083.2006.01853.x",
language = "English",
volume = "64",
pages = "633--638",
journal = "Scandinavian Journal of Immunology, Supplement",
issn = "0301-6323",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice

AU - Sorensen, G.L.

AU - Hjelmborg, J.V.B.

AU - Leth-Larsen, R.

AU - Schmidt, V.

AU - Fenger, Mogens

AU - Poulain, F.

AU - Hawgood, S.

AU - Sørensen, Thorkild I.A.

AU - Kyvik, K.O.

AU - Holmskov, U.

PY - 2006

Y1 - 2006

N2 - Surfactant protein D (SP-D) is a key regulator of pathogen-induced inflammation. SP-D is further involved in lipid homeostasis in mouse lung and circulation and recent data have demonstrated that the body mass index (BMI; in kg/m(2)) is influenced by genes in common with SP-D. The objective of the present study was to describe the association between serum SP-D and weight, waist circumference or BMI, and furthermore to observe body weight development in SP-D-deficient (Spd-/-) mice. As a part of the Danish population-based twin study (GEMINAKAR) on the metabolic syndrome, we analysed 1476 Danish twins for serum SP-D and investigated associations with weight, waist circumference and BMI by multiple regression analysis. Serum SP-D was significantly and inversely associated with weight (P = 0.001) and waist circumference in men (P < 0.001) and to BMI in both genders (P = 0.039 women, P < 0.001 men). The age-dependent increase in serum SP-D was most prominent in lean persons (BMI < 20). Spd-/- mice and wild-type mice were subjected to a feeding study and body weights were recorded in a time course over 24 weeks. Spd-/- mouse weight gain was significantly increased, with 90 mg/week (P < 0.0001) in males on normal chow. Fat percentage was significantly increased by 17% in the Spd-/- male mice (P = 0.003). We conclude, that there is an association between low levels or absent SP-D and obesity.

AB - Surfactant protein D (SP-D) is a key regulator of pathogen-induced inflammation. SP-D is further involved in lipid homeostasis in mouse lung and circulation and recent data have demonstrated that the body mass index (BMI; in kg/m(2)) is influenced by genes in common with SP-D. The objective of the present study was to describe the association between serum SP-D and weight, waist circumference or BMI, and furthermore to observe body weight development in SP-D-deficient (Spd-/-) mice. As a part of the Danish population-based twin study (GEMINAKAR) on the metabolic syndrome, we analysed 1476 Danish twins for serum SP-D and investigated associations with weight, waist circumference and BMI by multiple regression analysis. Serum SP-D was significantly and inversely associated with weight (P = 0.001) and waist circumference in men (P < 0.001) and to BMI in both genders (P = 0.039 women, P < 0.001 men). The age-dependent increase in serum SP-D was most prominent in lean persons (BMI < 20). Spd-/- mice and wild-type mice were subjected to a feeding study and body weights were recorded in a time course over 24 weeks. Spd-/- mouse weight gain was significantly increased, with 90 mg/week (P < 0.0001) in males on normal chow. Fat percentage was significantly increased by 17% in the Spd-/- male mice (P = 0.003). We conclude, that there is an association between low levels or absent SP-D and obesity.

U2 - 10.1111/j.1365-3083.2006.01853.x

DO - 10.1111/j.1365-3083.2006.01853.x

M3 - Journal article

C2 - 17083619

VL - 64

SP - 633

EP - 638

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 6

ER -

ID: 1207223