What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications? / Bonnefond, Amélie; Saulnier, Pierre-Jean; Stathopoulou, Maria G; Grarup, Niels; Ndiaye, Ndeye Coumba; Roussel, Ronan; Nezhad, Mohsen Azimi; Dechaume, Aurélie; Lantieri, Olivier; Hercberg, Serge; Lauritzen, Torsten; Balkau, Beverley; El-Sayed Moustafa, Julia S; Hansen, Torben; Pedersen, Oluf; Froguel, Philippe; Charpentier, Guillaume; Marre, Michel; Hadjadj, Samy; Visvikis-Siest, Sophie.

In: P L o S One, Vol. 8, No. 2, 02.2013, p. e55921.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bonnefond, A, Saulnier, P-J, Stathopoulou, MG, Grarup, N, Ndiaye, NC, Roussel, R, Nezhad, MA, Dechaume, A, Lantieri, O, Hercberg, S, Lauritzen, T, Balkau, B, El-Sayed Moustafa, JS, Hansen, T, Pedersen, O, Froguel, P, Charpentier, G, Marre, M, Hadjadj, S & Visvikis-Siest, S 2013, 'What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?', P L o S One, vol. 8, no. 2, pp. e55921. https://doi.org/10.1371/journal.pone.0055921

APA

Bonnefond, A., Saulnier, P-J., Stathopoulou, M. G., Grarup, N., Ndiaye, N. C., Roussel, R., Nezhad, M. A., Dechaume, A., Lantieri, O., Hercberg, S., Lauritzen, T., Balkau, B., El-Sayed Moustafa, J. S., Hansen, T., Pedersen, O., Froguel, P., Charpentier, G., Marre, M., Hadjadj, S., & Visvikis-Siest, S. (2013). What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications? P L o S One, 8(2), e55921. https://doi.org/10.1371/journal.pone.0055921

Vancouver

Bonnefond A, Saulnier P-J, Stathopoulou MG, Grarup N, Ndiaye NC, Roussel R et al. What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications? P L o S One. 2013 Feb;8(2):e55921. https://doi.org/10.1371/journal.pone.0055921

Author

Bonnefond, Amélie ; Saulnier, Pierre-Jean ; Stathopoulou, Maria G ; Grarup, Niels ; Ndiaye, Ndeye Coumba ; Roussel, Ronan ; Nezhad, Mohsen Azimi ; Dechaume, Aurélie ; Lantieri, Olivier ; Hercberg, Serge ; Lauritzen, Torsten ; Balkau, Beverley ; El-Sayed Moustafa, Julia S ; Hansen, Torben ; Pedersen, Oluf ; Froguel, Philippe ; Charpentier, Guillaume ; Marre, Michel ; Hadjadj, Samy ; Visvikis-Siest, Sophie. / What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?. In: P L o S One. 2013 ; Vol. 8, No. 2. pp. e55921.

Bibtex

@article{5623fc96350340c8b5ae1889509444fa,
title = "What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?",
abstract = "Vascular endothelial growth factor (VEGF) is a key chemokine involved in tissue growth and organ repair processes, particularly angiogenesis. Elevated circulating VEGF levels are believed to play a role in type 2 diabetes (T2D) microvascular complications, especially diabetic retinopathy. Recently, a genome-wide association study identified two common single nucleotide polymorphisms (SNPs; rs6921438 and rs10738760) explaining nearly half of the variance in circulating VEGF levels. Considering the putative contribution of VEGF to T2D and its complications, we aimed to assess the effect of these VEGF-related SNPs on the risk of T2D, nephropathy and retinopathy, as well as on variation in related traits.SNPs were genotyped in several case-control studies: French and Danish T2D studies (N(cases)¿=¿6,920-N(controls)¿=¿3,875 and N(cases)¿=¿3,561-N(controls)¿=¿2,623; respectively), two French studies one for diabetic nephropathy (N(cases)¿=¿1,242-N(controls)¿=¿860) and the other for diabetic retinopathy (N(cases)¿=¿1,336-N(controls)¿=¿1,231). The effects of each SNP on quantitative traits were analyzed in a French general population-based cohort (N¿=¿4,760) and two French T2D studies (N¿=¿3,480). SNP associations were assessed using logistic or linear regressions.In the French population, we found an association between the G-allele of rs6921438, shown to increase circulating VEGF levels, and increased T2D risk (OR¿=¿1.15; P¿=¿3.7×10(-5)). Furthermore, the same allele was associated with higher glycated hemoglobin levels ({\ss}¿=¿0.02%; P¿=¿9.2×10(-3)). However, these findings were not confirmed in the Danes. Conversely, the SNP rs10738760 was not associated with T2D in the French or Danish populations. Despite having adequate statistical power, we did not find any significant effects of rs6921438 or rs10738760 on diabetic microvascular complications or the variation in related traits in T2D patients.In spite of their impact on the variance in circulating VEGF, we did not find any association between SNPs rs6921438 and rs10738760, and the risk of T2D, diabetic nephropathy or retinopathy. The link between VEGF and T2D and its complications might be indirect and more complex than expected.",
author = "Am{\'e}lie Bonnefond and Pierre-Jean Saulnier and Stathopoulou, {Maria G} and Niels Grarup and Ndiaye, {Ndeye Coumba} and Ronan Roussel and Nezhad, {Mohsen Azimi} and Aur{\'e}lie Dechaume and Olivier Lantieri and Serge Hercberg and Torsten Lauritzen and Beverley Balkau and {El-Sayed Moustafa}, {Julia S} and Torben Hansen and Oluf Pedersen and Philippe Froguel and Guillaume Charpentier and Michel Marre and Samy Hadjadj and Sophie Visvikis-Siest",
year = "2013",
month = feb,
doi = "10.1371/journal.pone.0055921",
language = "English",
volume = "8",
pages = "e55921",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?

AU - Bonnefond, Amélie

AU - Saulnier, Pierre-Jean

AU - Stathopoulou, Maria G

AU - Grarup, Niels

AU - Ndiaye, Ndeye Coumba

AU - Roussel, Ronan

AU - Nezhad, Mohsen Azimi

AU - Dechaume, Aurélie

AU - Lantieri, Olivier

AU - Hercberg, Serge

AU - Lauritzen, Torsten

AU - Balkau, Beverley

AU - El-Sayed Moustafa, Julia S

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Froguel, Philippe

AU - Charpentier, Guillaume

AU - Marre, Michel

AU - Hadjadj, Samy

AU - Visvikis-Siest, Sophie

PY - 2013/2

Y1 - 2013/2

N2 - Vascular endothelial growth factor (VEGF) is a key chemokine involved in tissue growth and organ repair processes, particularly angiogenesis. Elevated circulating VEGF levels are believed to play a role in type 2 diabetes (T2D) microvascular complications, especially diabetic retinopathy. Recently, a genome-wide association study identified two common single nucleotide polymorphisms (SNPs; rs6921438 and rs10738760) explaining nearly half of the variance in circulating VEGF levels. Considering the putative contribution of VEGF to T2D and its complications, we aimed to assess the effect of these VEGF-related SNPs on the risk of T2D, nephropathy and retinopathy, as well as on variation in related traits.SNPs were genotyped in several case-control studies: French and Danish T2D studies (N(cases)¿=¿6,920-N(controls)¿=¿3,875 and N(cases)¿=¿3,561-N(controls)¿=¿2,623; respectively), two French studies one for diabetic nephropathy (N(cases)¿=¿1,242-N(controls)¿=¿860) and the other for diabetic retinopathy (N(cases)¿=¿1,336-N(controls)¿=¿1,231). The effects of each SNP on quantitative traits were analyzed in a French general population-based cohort (N¿=¿4,760) and two French T2D studies (N¿=¿3,480). SNP associations were assessed using logistic or linear regressions.In the French population, we found an association between the G-allele of rs6921438, shown to increase circulating VEGF levels, and increased T2D risk (OR¿=¿1.15; P¿=¿3.7×10(-5)). Furthermore, the same allele was associated with higher glycated hemoglobin levels (߿=¿0.02%; P¿=¿9.2×10(-3)). However, these findings were not confirmed in the Danes. Conversely, the SNP rs10738760 was not associated with T2D in the French or Danish populations. Despite having adequate statistical power, we did not find any significant effects of rs6921438 or rs10738760 on diabetic microvascular complications or the variation in related traits in T2D patients.In spite of their impact on the variance in circulating VEGF, we did not find any association between SNPs rs6921438 and rs10738760, and the risk of T2D, diabetic nephropathy or retinopathy. The link between VEGF and T2D and its complications might be indirect and more complex than expected.

AB - Vascular endothelial growth factor (VEGF) is a key chemokine involved in tissue growth and organ repair processes, particularly angiogenesis. Elevated circulating VEGF levels are believed to play a role in type 2 diabetes (T2D) microvascular complications, especially diabetic retinopathy. Recently, a genome-wide association study identified two common single nucleotide polymorphisms (SNPs; rs6921438 and rs10738760) explaining nearly half of the variance in circulating VEGF levels. Considering the putative contribution of VEGF to T2D and its complications, we aimed to assess the effect of these VEGF-related SNPs on the risk of T2D, nephropathy and retinopathy, as well as on variation in related traits.SNPs were genotyped in several case-control studies: French and Danish T2D studies (N(cases)¿=¿6,920-N(controls)¿=¿3,875 and N(cases)¿=¿3,561-N(controls)¿=¿2,623; respectively), two French studies one for diabetic nephropathy (N(cases)¿=¿1,242-N(controls)¿=¿860) and the other for diabetic retinopathy (N(cases)¿=¿1,336-N(controls)¿=¿1,231). The effects of each SNP on quantitative traits were analyzed in a French general population-based cohort (N¿=¿4,760) and two French T2D studies (N¿=¿3,480). SNP associations were assessed using logistic or linear regressions.In the French population, we found an association between the G-allele of rs6921438, shown to increase circulating VEGF levels, and increased T2D risk (OR¿=¿1.15; P¿=¿3.7×10(-5)). Furthermore, the same allele was associated with higher glycated hemoglobin levels (߿=¿0.02%; P¿=¿9.2×10(-3)). However, these findings were not confirmed in the Danes. Conversely, the SNP rs10738760 was not associated with T2D in the French or Danish populations. Despite having adequate statistical power, we did not find any significant effects of rs6921438 or rs10738760 on diabetic microvascular complications or the variation in related traits in T2D patients.In spite of their impact on the variance in circulating VEGF, we did not find any association between SNPs rs6921438 and rs10738760, and the risk of T2D, diabetic nephropathy or retinopathy. The link between VEGF and T2D and its complications might be indirect and more complex than expected.

U2 - 10.1371/journal.pone.0055921

DO - 10.1371/journal.pone.0055921

M3 - Journal article

C2 - 23405237

VL - 8

SP - e55921

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

ER -

ID: 44862497